Effects of Resisted Versus Balance Exercises on Cognitive And Motor Function In Patients With Mild Cognitive Impairment

NCT06308237 | Completed DMC

• 1 other identifier: REC/RCR&AHS/23/0293
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

Mild cognitive impairment affects older adults and it includes memory and attentions deficits, and problem-solving difficulties in activities of daily living. Resisted exercises is considered a viable strategy to improve balance and motor function in older population. Balance exercises comprises proprioceptive, visual and motor learning to a larger degree and has positive effects on memory and spatial cognition and improves balance and motor function. This study aims to determine the effects of resisted and balance exercises on cognition and motor function in patients with mild cognitive impairment.

Conditions

Mild Cognitive Impairment

Keywords

Cognition; Motor control; Randomized clinical trial

Outcome Measures

Primary Outcomes (3)

• MoCA (Montreal Cognitive Assessment )

  The Montreal Cognitive Assessment (MoCA) will be used as a screening tool as well as assessment tool for cognition. It is a one-page, 30-point cognitive screening measurement scale that takes about 10 minutes to administer

  14th week

• Mini-Balance Evaluation Systems Test (BESTest).

  It aims to target and identify 6 different balance control systems so that specific rehabilitation approaches can be designed for different balance deficits.It is a 14-item test scored on a 3-level ordinal scale.

  16th week

• Timed UP and GO Test (TUG) :

  The Timed Up and Go test (TUG) will be used as a screening as well as assessment scale for balance and motor function. It can measures in seconds the time it takes a subject to rise from a chair, walk a distance of 3 meters, turn, walk back to the chair and sit down.This test has been used extensively in geriatric medicine to examine balance, gait speed, and functional ability that would be required for the performance of basic activities of daily living in older people.

  16th week

Study Arms (2)

GROUP A (RESISTED EXERCISES)

EXPERIMENTAL

Group A will receive a session of resisted exercises for 30 minutes. Treatment session will be given for 3 days per week for 12 weeks. This resisted training exercise program consist of three phases: Warm-up phase (5 minutes, after Warm-Up phase 20 minutes resisted exercise training then cooling phase (5 minutes).

Other: RESISTED EXERCISES

GROUP B (BALANCE EXERCISES)

EXPERIMENTAL

Group B will receive a session of Balance exercises for 30 minutes. Treatment session will be given for 3 days per week for 12 weeks. This balance exercise program consist of three phases:Warm-up phase (5 minutes), after Warm-Up phase, 20 minutes balance exercise training then cooling phase (5 minutes).

Other: BALANCE EXERCISES

Interventions

RESISTED EXERCISES OTHER

Patients will perform Chest plank for 30 seconds with 4 repetitions. Then the Participants will perform these exercises for 1 minute each with 4 repetitions: Wide grip lateral pull down , Lying triceps press, Sit up squats, Barbell curl each. And will perform Thigh adduction for1 minute with 2 repititions.

GROUP A (RESISTED EXERCISES)

BALANCE EXERCISES OTHER

Static and dynamic balance exercises will include: Patients will perform Arm abduction holding a half-kg dumbbell, Opposite arm and leg in a quadruped position, Walking in a tandem stance(forward and backward), Turning and bending to the sides in a standing position, Pass through obstacles in a spiral, for 2 minutes each. Then they will perform throwing a medicine ball to investigator and back while trying to maintain balance, Tandem stance, Walking backwards, Two-leg bridge as well as single (2 repetitions), Leg bridge (raising the other leg), walking on the heel, performing rhythmic movements while stepping on a circular environment and balance board exercises, for 1 minute each. And will Walk up and down the stairs for 3 minutes.

GROUP B (BALANCE EXERCISES)

Eligibility Criteria

• Age: 60 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with Mild Cognitive Impairment. (Having score between 18 - 24) on MoCA.
• Participants with Both Genders will be included .
• The Age limit for the participants will be 60 to 75 years.
• Patients having Independence of life (ability to walk independently without any walking aid).

You may not qualify if:

• Previous and current History Cardiovascular, neurological, psychiatric and motor disorders like (fractures, diagnosis of Osteoporosis)
• Patients taking any medication for mild cognition.
• Depressive symptoms, acute and chronic conditions that would preclude exercise, regular exercise (\>30 min/day, \>3days/week).
• Patients having estrogen replacement therapy.
• Simultaneous participation in other studies.
• Regular physical activity (once a week during the last 3 months); physio therapeutic treatment in the last 3 months.
• Diseases that promote incapacity; severe visual deficiency; recurrent vertigo; and uncontrolled systemic arterial hypertension.

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Riphah International University

Lahore, Punjab Province, 54660, Pakistan

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Muhammad Kashif, Phd-PT

  Riphah International University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The study would be single blinded as assessor of the study would be kept blind of the treatment groups to which patient will be allocated.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 4, 2024
• First Posted: March 13, 2024
• Study Start: February 25, 2024
• Primary Completion: July 10, 2024
• Study Completion: July 10, 2024
• Last Updated: October 15, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)