Post-activation Performance Enhancement Improves

NCT06825065 | Completed

• 2 other identifiers: GAUN-SBF-PANCAR-032022/373
• Study Type: interventional
• Target: 9
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the acute effects of Post-Activation Performance Enhancement (PAPE) on the number of repetitions performed to volitional failure and total training volume in resistance-trained men. The research is designed as a randomized crossover trial where participants perform two different exercise protocols under controlled conditions. The study includes 9 healthy, strength-trained male volunteers aged 18-30 years, with at least one year of resistance training experience. Participants complete two experimental conditions: PAPE Protocol: A warm-up followed by 3 repetitions at 90% of 1RM, a 10-minute rest, and then 3 sets of half-squat at 75% 1RM until volitional failure. Control (CON) Protocol: A warm-up followed by 8 repetitions at 50% of 1RM, a 4-minute rest, and then 3 sets of half-squat at 75% 1RM until volitional failure. The primary outcome measures are: Total training volume (set × reps × weight) Number of repetitions performed The study aims to determine whether PAPE improves total volume and repetition performance in resistance training. The findings could contribute to better training strategies for athletes and fitness professionals. Ethical approval was obtained from the Gaziantep University Clinical Research Ethics Committee (Decision No: 2022/373), and all participants provided informed consent before participation.

Conditions

Resistance Exercise

Keywords

Post-Activation Performance; Resistance Training; Failure

Outcome Measures

Primary Outcomes (1)

• Total Training Volume (kg)

  The total volume lifted during the half-squat exercise. It is calculated as set × repetitions × load for each set across all sets.

  Immediately after exercise and 30 minutes post-exercise

Secondary Outcomes (1)

• Number of Repetitions Performed to Volitional Failure

  Immediately after exercise and 30 minutes post-exercise

Study Arms (2)

PAPE Protocol

EXPERIMENTAL

Participants in this group will first perform a warm-up consisting of 3 repetitions at 90% of their 1RM. After a 10-minute rest, they will perform 3 sets of half-squats at 75% of their 1RM until volitional failure.

Behavioral: PAPE Protocol

Control Protocol

ACTIVE COMPARATOR

Participants in this group will perform a warm-up consisting of 8 repetitions at 50% of their 1RM. After a 4-minute rest, they will perform 3 sets of half-squats at 75% of their 1RM until volitional failure.

Behavioral: Control Protocol

Interventions

PAPE Protocol BEHAVIORAL

In this intervention, participants perform a warm-up consisting of 3 repetitions at 90% of 1RM. After a 10-minute rest, they perform 3 sets of half-squats at 75% of their 1RM until volitional failure. This protocol is designed to enhance performance through the post-activation potentiation effect.

PAPE Protocol

Control Protocol BEHAVIORAL

In this intervention, participants perform a warm-up consisting of 8 repetitions at 50% of 1RM. After a 4-minute rest, they perform 3 sets of half-squats at 75% of their 1RM until volitional failure. This protocol is used as a baseline for comparison with the PAPE protocol.

Control Protocol

Eligibility Criteria

• Age: 18 Years - 30 Years
• Gender Eligibility Details: Only individuals who self-identify as male are eligible to participate in this study. The study is limited to biological males, as all participants are required to be trained male athletes.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Participants must be 18-30 years old.
• Only biologically male participants are eligible to participate in the study.
• Participants must have at least 1 year of continuous resistance training experience.
• Participants should be healthy, with no musculoskeletal disorders or injuries in the previous 6 months.
• Participants must have experience in performing the half-squat exercise as part of their regular training routine.
• Participants must be willing to provide written informed consent to participate in the study.

You may not qualify if:

• Participants who are currently using performance-enhancing drugs or have a history of chronic drug use.
• Participants with a history of neuromuscular disease, metabolic disorders, hormonal imbalances, cardiovascular diseases, or any orthopedic limitations.
• Participants who are using supplements such as caffeine or any other substances that might interfere with performance or the study protocol.
• Participants who perform high-intensity aerobic training or resistance training outside their routine, which may interfere with study procedures.

Sponsors & Collaborators

• University of Gaziantep: lead

Study Sites (1)

Gaziantep University, Faculty of Sport Sciences

Gaziantep, Şehitkamil, 27350, Turkey (Türkiye)

Location

Study Officials

• Zarife Pancar Assistant Professor, PhD

  University of Gaziantep

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: This is a single-blind study where the participants are unaware of which protocol (PAPE or Control) they are assigned to during each session. The investigators who administer the protocols and measure the outcomes are also aware of the assignment. The randomization process is done prior to each session to determine the order of protocols.
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: This model is suitable because your study uses a randomized crossover design, where each participant undergoes both the PAPE and Control (CON) protocols in a randomized order, with a washout period between them to ensure full recovery.

Study Record Dates

• First Submitted: February 4, 2025
• First Posted: February 13, 2025
• Study Start: March 10, 2024
• Primary Completion: April 10, 2024
• Study Completion: April 28, 2024
• Last Updated: January 20, 2026

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, CSR
• Time Frame: IPD and supporting information will be made available 6 months after the completion of data collection. The data will be accessible for 2 years following the publication of the study results, and will be shared with researchers upon request.
• Access Criteria: Access will be provided electronically, through secure platforms like Data Access Repositories or institutional databases, with data being made available upon approval of the request.

Locations

TU (1)