Different Order of Concurrent Training on Improving Visceral Adipose Tissue and Insulin Resistance.

NCT05580263 | Completed DMC

• 1 other identifier: 110-551
• Study Type: interventional
• Target: 92
• Locations: 1 country
• Sites: 1

Brief Summary

Purposes: The purpose of one-year project is to compare the effect of different intrasession exercise order of AE and RE during concurrent training on reducing VAT and improving insulin resistance for inactive middle-age community residents with obesity. Methods: Purposive sampling will be used to enroll community residents aged 40-64 years with inactive habit and body fat percentage ≧ 25% for male and ≧ 30% for female in southern Taiwan. Eligible participants will be stratified by sex and age (40-55years and 56-64 years) then block randomly divided into training group of AE preceding RE, RE preceding AE or a control group. The exercise training program will under supervision lasting 16 weeks with 3 times per week. The concurrent training prescription consist of AE 30 minutes and RE 15 minutes per session. A 5-minute interval between two exercise modalities. All participants will be evaluated outcomes for two time points including baseline (T0) and after 16-week intervention (T1). The primary outcomes are VAT and insulin resistance. A two-way ANOVA with repeated measures will be performed to compare changes of outcome variables over the intervention period. Relevance to clinical practice: The results of this project can assist health professionals to know how to properly prescribe concurrent training of AE and RE to achieve the greatest effects on VATreduction and insulin resistance improvement for middle-age residents with obesity.

Conditions

Fat Burn; Aerobic Exercise; Resistance Exercise

Outcome Measures

Primary Outcomes (6)

• visceral adipose tissue

  Participants will measure visceral adipose tissue measure at baseline by body composition analyzer.

  at baseline

• visceral adipose tissue

  Participants will measure visceral adipose tissue measure after 16-week intervention by body composition analyzer.

  16-week after intervention

• Insulin

  Participants will collect insulin at baseline by blood samples

  at baseline

• Insulin

  Participants will collect insulin after 16-week intervention by blood samples

  16-week after intervention

• Fasting glucose

  Participants will collect fasting glucose at baseline by blood samples

  at baseline

• Fasting glucose

  Participants will collect fasting glucose after 16-week intervention by blood samples

  16-week after intervention

Secondary Outcomes (8)

• waist circumference

  at baseline

• waist circumference

  16-week after intervention

• hip circumference

  at baseline

• hip circumference

  16-week after intervention

• weight

  at baseline

Study Arms (3)

aerobic exercise(AE) preceding resistance exercise(RE)

EXPERIMENTAL

at least moderate intensity of AE 30 minutes than RE 15 minutes, with a break of 5 minutes between two modalities of training.

Behavioral: aerobic exercise; Behavioral: resistance exercise

RE preceding AE

EXPERIMENTAL

RE 15 minutes than at least moderate intensity of AE 30 minutes, with a break of 5 minutes between two modalities of training.

Behavioral: aerobic exercise; Behavioral: resistance exercise

Control group

NO INTERVENTION

Participants maintain their usual life without any exercise intervention.

Interventions

aerobic exercise BEHAVIORAL

The main AE program will be designed and controlled for at least moderate intensity of heart rate reserve (HRR) lasting 30 minutes. The goal of intensity will be set at least 40% of HRR during the first two weeks, and then progressively increase the targeted intensity at the end of 16 weeks with 60% HRR. The motions will design by involving core muscle training (e.g., march, step touch, lunge, V-step, box step, twist, knee up, scoop, and scissors).

RE preceding AE; aerobic exercise(AE) preceding resistance exercise(RE)

resistance exercise BEHAVIORAL

In the process, the participants will be instructed by resisting the weight smoothly, and peaking at hold. RE prescription consist of 2-4 sets with 10-15 repetitions per set with a rest interval of 1-2 minutes between sets to improve muscular fitness. The first two weeks will start with two sets of 10-15 repetitions and then gradually progress on four sets of 15 repetitions at the end of 16 weeks. The total duration of RE will lasting around 15 minutes.

RE preceding AE; aerobic exercise(AE) preceding resistance exercise(RE)

Eligibility Criteria

• Age: 40 Years - 64 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• to 64 years old.
• body fat percentage ≧ 25% for male and ≧ 30% for female.
• with inactive habit (≤ 3 days of physical activity per week and ≤ 30 min per session).
• can communicate in Mandarin or Taiwanese.

You may not qualify if:

• with recent unstable conditions in which had potential risk on exercise including stroke, cardiovascular and respiratory diseases, handicap, pregnancy.
• with any contraindications to body composition analyzer measurement including body embed pacemakers and artificial metal joints, amputated hands or feet.
• cannot corporate with either examination or intervention.
• use psychotropic or appetite-regulating medicine.
• under oral hopoglycemic agent or insulin treatment.

Sponsors & Collaborators

• National Tainan Junior College of Nursing: lead

Study Sites (1)

Natioal Tainan Junior College of Nursing

Tainan, 700, Taiwan

Location

MeSH Terms

Interventions

Exercise; Resistance Training

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human

Study Officials

• Yu-Hsuan Chang, phD

  National Tainan Junior College of Nursing

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: PI (data assessor) will be blinded for the grouping.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: October 3, 2022
• First Posted: October 14, 2022
• Study Start: October 31, 2022
• Primary Completion: June 30, 2023
• Study Completion: June 30, 2023
• Last Updated: February 6, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)