Combined Upper Extremity Resistance and Aerobic Exercise Training in Patients With Breast Cancer

NCT07070791 | Recruiting

• 1 other identifier: 2025/5-47
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

According to updated data from the International Agency for Research on Cancer (IARC) for 2022, breast cancer in women is responsible for one in four cancer cases and one in six cancer deaths worldwide and is the second leading cause of global cancer incidence, accounting for 11.6% of all cancer cases, and the fourth leading cause of cancer deaths worldwide, accounting for 6.9% of all cancer deaths. During or after breast cancer treatments, there is exposure to a variety of direct (local/regional treatment, systemic treatment and supportive care) and indirect factors (modifiable and non-modifiable risk factors) that may have adverse effects on treatment-related haematological, cardiovascular, pulmonary and musculoskeletal components. Upper limb dysfunction and lymphoedema have been reported to be two of the most common side effects affecting the quality of life of breast cancer patients after breast cancer treatments. The elastic resistance band, which is widely used in strength training, has the advantage of being applied to various classes because it provides resistance angles in various postures and has a low risk of injury. However, few studies have been conducted on elastic resistance band application in patients with breast cancer. At the same time, evidence on the effectiveness of upper extremity aerobic exercise training in patients with breast cancer is limited. Therefore, this study aimed to investigate the effects of upper extremity aerobic exercise training combined with progressive resistance training and upper extremity aerobic exercise training alone on upper extremity exercise capacity, upper extremity functionality, sarcopenia, frailty, quality of life and lymphedema in patients with breast cancer.

Conditions

Upper Extremity; Resistance Exercise; Aerobic Exercise; Breast Cancer

Keywords

breast cancer; Upper Extremity; resistance exercise training; Aerobic exercise training

Outcome Measures

Primary Outcomes (2)

• 6 minute Pegboard and Ring Test - 6PBRT

  Total number of rings inserted in six minutes

  One Year

• Maximal Arm Exercise Capacity

  VO2peak requirement during arm ergometry will be estimated using MET levels calculated at each power output based on gender at various body weights and will be displayed in ml/kg/min (1 MET = 3.5 ml/kg/min)

  One Year

Secondary Outcomes (9)

• Evaluation of Quality of Life

  One Year

• Peripheral Muscle Strength

  One Year

• Anthropometric Measurements

  One Year

• Comorbidity Assessment

  One Year

• Peripheral muscle strength assessment

  One Year

Study Arms (2)

Upper Extremity Aerobic Exercise

ACTIVE COMPARATOR

Participants will only receive a 12-week upper limb aerobic exercise training program.

Other: Upper Extremity Aerobic Exercise Training

Upper Extremity Progressive Resistance Training Combined with Aerobic Exercise Training

EXPERIMENTAL

Participants will receive a 12-week upper extremity aerobic exercise training program plus upper extremity progressive resistance exercise training.

Other: Upper Extremity Aerobic Exercise Training; Other: Upper Extremity Progressive Resistance Exercise Training

Interventions

Upper Extremity Progressive Resistance Exercise Training OTHER

Upper extremity progressive resistance training was gradually increased over 12 weeks using elastic resistance bands.

Upper Extremity Progressive Resistance Training Combined with Aerobic Exercise Training

Upper Extremity Aerobic Exercise Training OTHER

12 weeks of upper extremity aerobic exercise training, 3 sessions per week, 25 minutes per session.

Upper Extremity Aerobic Exercise; Upper Extremity Progressive Resistance Training Combined with Aerobic Exercise Training

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• To be between 18-80 years old,
• Volunteering to participate in the research,
• At least 15 months after breast cancer surgery,
• No problems in reading and/or understanding the scales and being able to co-operate with the tests.
• Physically inactive (60 minutes of structured exercise per week \<).

You may not qualify if:

• Presence of active infection,
• Presence of bilateral breast cancer,
• History of surgical, neurological or orthopaedic problems that may affect upper extremity functionality other than breast cancer surgery,
• Having a neurological disease or other clinical diagnosis that may affect cognitive status,
• Musculoskeletal and neurological disease that may affect exercise performance, symptomatic heart disease, previous lung surgery and malignant disease.
• Presence of unstable hypertension or diabetes mellitus.

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hcettepe University

Ankara, State, 06100, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Melda Saglam, PhD

  Hacettepe University

  STUDY CHAIR

• Ebru Calik Kutukcu, PhD

  Hacettepe University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ebru Calik Kutukcu, PhD

CONTACT

+903123051576; ebru.calik@hacettepe.edu.tr

Naciye Vardar-Yagli, PhD

CONTACT

+03123051576; naciyevardar@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: The study consisted of two groups: one group performed upper extremity aerobic exercise while the other group performed both upper extremity aerobic exercise and upper extremity progressive resistance training.

Study Record Dates

• First Submitted: July 9, 2025
• First Posted: July 17, 2025
• Study Start: July 8, 2025
• Primary Completion: May 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: December 29, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)