Can Computational Measures of Task Performance Predict Psychiatric Symptoms and Changes in Symptom Severity Across Time

NCT06705179 | Not Yet Recruiting

• 1 other identifier: 1R01MH138895
• Study Type: interventional
• Target: 1,100
• Locations: 1 country
• Sites: 2

Brief Summary

This study investigates the computational mechanisms associated with psychiatric disease dimensions. The study will characterize the relationship between computational parameter estimates of task performance and psychiatric symptoms and diagnoses with a longitudinal approach over a 12 month interval. Participants will be healthy participants recruited through Prolific an on-line crowdsourcing service, and psychiatric patients and healthy participants recruited via UCLA Psychiatry Clinics and UCLA's STAND Program

Conditions

Behavior; Depressive Disorder; Anxiety Disorders; Obsessive Compulsive Disorder (OCD)

Keywords

Computational Psychiatry; Behavioral task battery

Outcome Measures

Primary Outcomes (6)

• Changes in DASS depression scale scores

  Changes in computational parameter estimates related to gain/loss learning, reward/effort tradeoff and reward/predation risk tradeoffs will correlate with changes in DASS depression scale scores across time.

  12 months

• Changes in DASS anxiety scale scores

  Changes in computational parameter estimates related to novelty driven exploration and reward/predation risk tradeoffs will be correlated with changes in DASS anxiety scale scores

  12 months

• Changes in OCI-R scores

  Changes in computational parameter estimates related to the balance between model-based vs model-free reinforcement-learning will be correlated with changes in OCI-R symptoms across time.

  12 months

• OCI-R scores

  Computational parameter estimates related to the balance between model-based vs model-free reinforcement-learning will be correlated with OCI-R scores.

  12 months

• DASS depression scale scores

  Computational parameter estimates related to gain/loss learning, reward/effort tradeoff and reward/predation risk tradeoffs will correlate with DASS depression scale scores.

  12 months

• DASS anxiety scale scores

  Computational parameter estimates related to novelty driven exploration and reward/predation risk tradeoffs will be correlated with DASS anxiety scale scores

  12 months

Study Arms (1)

Behavioral task battery

OTHER

Behavioral: Behavioral task performance

Interventions

Behavioral task performance BEHAVIORAL

Measures of performance on behavioral tasks

Behavioral task battery

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age range of 18 to 65.
• Not currently having a psychiatric diagnosis determined after psychiatric evaluation by Drs. Tadayon-Nejad and Wei (both are board certified psychiatrists).
• Ability to understand and perform experimental tasks, i.e. basic ability to communicate and comprehend tasks.
• Ability to give informed consent.

You may not qualify if:

• Prior history and or current diagnosis of neurological disease.
• Age range of 18 to 65.
• Psychiatric diagnosis of any type of depressive disorders, any type of anxiety disorders or obsessive-compulsive disorder.
• Primary or comorbid bipolar disorders are allowed but only if not in the acute manic phase.
• Comorbidity with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are allowed.
• Ability to understand and perform experimental tasks, i.e. basic ability to communicate and comprehend tasks.
• Ability to give informed consent.
• Prior history and or current diagnosis of neurological disease.
• History or current diagnosis of psychotic disorders.
• Currently active substance use disorder.

Sponsors & Collaborators

• California Institute of Technology: lead

Study Sites (2)

UCLA Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles

Los Angeles, California, 90095, United States

Location

California Insitute of Technology

Pasadena, California, 91125, United States

Location

MeSH Terms

Conditions

Behavior; Depressive Disorder; Anxiety Disorders; Obsessive-Compulsive Disorder

Condition Hierarchy (Ancestors)

Mood Disorders; Mental Disorders

Study Officials

• John P O'Doherty, D.Phil

  California Institute of Technology

  PRINCIPAL INVESTIGATOR

Central Study Contacts

John P O'Doherty, D.Phil

CONTACT

626-395-5981; jdoherty@hss.caltech.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Fletcher Jones Professor of Decision Neuroscience

Study Record Dates

• First Submitted: November 18, 2024
• First Posted: November 26, 2024
• Study Start: January 1, 2025
• Primary Completion (Estimated): December 31, 2029
• Study Completion (Estimated): December 31, 2029
• Last Updated: November 26, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: ANALYTIC CODE
• Access Criteria: Data will be provided to the NIH NDA database as requested per the grant conditions,

Locations

US (2)