Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
2 other identifiers
interventional
70
1 country
1
Brief Summary
This research study aims to develop a brief group-based treatment called Resilience Training for Teens, then to test how well it protects high school students with mild symptoms of depression, anxiety, or having unusual feelings from developing mental illnesses.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Mar 2024
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 17, 2023
CompletedFirst Posted
Study publicly available on registry
July 27, 2023
CompletedStudy Start
First participant enrolled
March 22, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 31, 2027
December 9, 2025
December 1, 2025
3.4 years
July 17, 2023
December 2, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Structured Interview of Psychosis-risk Syndromes (SIPS)
Subclinical psychotic symptoms that represent a risk of transdiagnostic mental illnesses. This semi-structured interview rates psychotic experiences, general symptoms, and functioning. The SIPS interview assesses positive, negative, disorganized, and general symptoms. The range of the Scale of Psychosis-risk Symptoms (SOPS) is 0-6, with a higher score representing more severe symptoms.
1 year
Secondary Outcomes (2)
Child Behavior Checklist (CBCL)
1 year
Global Functioning Social and Role Scales
1 year
Study Arms (2)
Resilience Training for Teens
EXPERIMENTALA brief 6-session group-based behavioral intervention for teens at risk of a mental illness.
Waitlist
NO INTERVENTIONA one year waitlist period where participants will not participate in Resilience Training for Teens. Following that one year waitlist period, they can participate in Resilience Training for Teens.
Interventions
A brief 6-session group-based behavioral intervention for high school aged teenagers at risk of a mental illness.
Eligibility Criteria
You may qualify if:
- Currently enrolled in 9th through 12th grade and between the ages of 14 and 19
- Endorsed at least one psychotic experience
- Provided contact information
- Have a parent or legal guardian who is able and willing to provide written informed consent (if under the age of 18)
- Have a parent or legal guardian who is able and willing to participate in a parent session
- Competent and willing to provide written informed assent (if under the age of 18) or consent (if age 18 or older)
- Able to communicate in English
You may not qualify if:
- Currently prescribed psychotropic medication (not including medications for attention deficit/hyperactivity disorder), regardless of adherence
- Currently obtaining psychotherapeutic intervention
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
July 17, 2023
First Posted
July 27, 2023
Study Start
March 22, 2024
Primary Completion (Estimated)
July 31, 2027
Study Completion (Estimated)
July 31, 2027
Last Updated
December 9, 2025
Record last verified: 2025-12