Effects of Increased Greek Yogurt Consumption in Senior Adults

NCT06530394 | Completed

• 1 other identifier: REB 23-354
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to examine whether Greek yogurt (GY) consumption will lead to beneficial changes in bone metabolism and inflammation, in senior adults, male and female, when combined with regular exercise (senior fit classes; GYEX) and without exercise (GYNE). It is hypothesized that compared to a control group (senior fit classes, no GY; NYEX), an 8-week GY consumption intervention in senior adults with and without exercise will lead to positive effects on body composition, and markers of bone metabolism and inflammation such that the anabolic and anti-inflammatory markers of these physiological processes will increase more than any training-induced catabolic and pro-inflammatory markers (i.e., more than measures observed in the NYNE group).

Conditions

Osteoporosis; Inflammation

Outcome Measures

Primary Outcomes (12)

• Serum concentrations of osteocalcin

  Bone turnover marker measured in picograms/milliliter of serum (pg/mL)

  Weeks 0 and 8

• Serum concentrations of amino-terminal propeptide of type I collagen (P1NP)

  Bone formation marker measured in pg/mL

  Weeks 0 and 8

• Serum concentrations of C-telopeptides of type I collagen (CTX)

  Bone resorption marker measured in ng/mL

  Weeks 0 and 8

• Serum concentrations of osteoprotegerin (OPG)

  Regulator of bone remodelling (osteokine) measured in pg/mL

  Weeks 0 and 8

• Serum concentrations of sclerostin

  Regulator of bone remodelling (osteokine) measured in pg/mL

  Weeks 0 and 8

• Serum concentrations of receptor activator of nuclear factor kappa-Β ligand (RANKL)

  Regulator of bone remodelling (osteokine) measured in pg/mL

  Weeks 0 and 8

• Serum concentrations of parathyroid hormone (PTH)

  Regulator of bone remodelling measured in pg/mL

  Weeks 0 and 8

• Plasma concentrations of interleukin-6 (IL6)

  Inflammatory cytokine measured in pg/mL

  Weeks 0 and 8

• Plasma concentrations of interleukin-10 (IL10)

  Anti-inflammatory cytokine measured in pg/mL

  Weeks 0 and 8

• plasma concentrations of inflammatory cytokines, including interleukin-6 (IL6), interleukin-10 Plasma concentrations of tumour necrosis factor-alpha (TNFα)

  Pro-inflammatory cytokine measured in pg/mL

  Weeks 0 and 8

• Serum concentrations of irisin

  Myokine measured in pg/mL

  Weeks 0 and 8

• Serum concentrations of insulin-like growth factor 1 (IGF1)

  Growth factor measured in pg/mL

  Weeks 0 and 8

Secondary Outcomes (5)

• Body mass

  Weeks 0 and 8

• Body composition

  Weeks 0 and 8

• Height

  Weeks 0 and 8

• Energy intake and expenditure

  Weeks 0 and 8

• Sport-Specific Nutrition Knowledge Questionnaire (GeSNK)

  Weeks 0 and 8

Study Arms (3)

Greek yogurt exercising group (GYEX)

EXPERIMENTAL

Participants will be asked to consume 2 servings/day (preferably morning and night) of 175 g commercially available GY (0% MF, flavoured, 130 calories, 17 g protein, 225 g calcium (e.g., OIKOS High Protein GY) for a total of 8 weeks. For their convenience, the participants will be provided with appropriate scoops to measure out 175 g of GY per serving of the larger 650 g commercially available, pre-packaged containers. Although it is recommended to consume the two servings morning and night, to increase ecological validity and strengthen the feasibility of the intervention, the timing of the servings will be flexible to facilitate daily routines and lifestyles. For the same reasons, the participants will be able to choose the flavour of their GY.

Dietary Supplement: Greek yogurt

Control exercising group (NYEX)

NO INTERVENTION

During the 8-weeks, participants will be instructed to follow their typical, habitual diet and exercise regimen.

Intervention non-exercising group (GYNE)

ACTIVE COMPARATOR

Participants will be instructed to follow their typical habitual diet. Participants will be asked to consume 2 servings/day (preferably morning and night) of 175 g commercially available GY (0% MF, flavoured, 130 calories, 17 g protein, 225 g calcium; e.g., OIKOS High Protein GY) for a total of 8 weeks. For their convenience, the participants will be provided with appropriate scoops to measure out 175 g of GY per serving of the larger 650 g commercially available, pre-packaged containers. Although it is recommended to consume the two servings morning and night, to increase ecological validity and strengthen the intervention's feasibility, the servings' timing will be flexible to facilitate daily routines and lifestyles. For the same reasons, the participants will be able to choose the flavour of their GY.

Dietary Supplement: Greek yogurt

Interventions

Greek yogurt DIETARY_SUPPLEMENT

Whole food dairy products, such as Greek yogurt (GY), offer a high quality, nutrient-dense snack, high in bone-supporting ingredients, including protein, calcium, and phosphorus. These nutrients are crucial to the structural integrity and strength of bone, i.e., the collagen and hydroxyapatite matrices.

Greek yogurt exercising group (GYEX); Intervention non-exercising group (GYNE)

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults 55+ years from from the Niagara area.

You may not qualify if:

• injuries and inability to participate in classes,
• allergy to dairy foods/dairy protein, or
• diagnosed with lactose intolerance.

Sponsors & Collaborators

• Brock University: lead

Study Sites (1)

Brock University

St. Catharines, Ontario, L2S 3A1, Canada

Location

MeSH Terms

Conditions

Osteoporosis; Inflammation

Condition Hierarchy (Ancestors)

Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Independent blind researchers will analyze blood and data using masked participant codes.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Participants will be invited to participate in this 8-week study, with senior fit participants being randomly assigned into the control (NYEX) or the intervention exercising (GYEX) group and non-senior fit citizens from the Niagara community will be assigned to the intervention non-exercising group (GYNE).

Study Record Dates

• First Submitted: July 28, 2024
• First Posted: July 31, 2024
• Study Start: August 10, 2024
• Primary Completion: June 30, 2025
• Study Completion: August 28, 2025
• Last Updated: September 5, 2025

Record last verified: 2025-08

Locations

CA (1)