NCT07126002

Brief Summary

This study was designed to evaluate the impact of a 16-week yoga program on BMD, bone metabolism markers, and physical fitness in elderly patients with OP.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jul 2024

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2024

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2024

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

July 31, 2025

Completed
15 days until next milestone

First Posted

Study publicly available on registry

August 15, 2025

Completed
Last Updated

August 15, 2025

Status Verified

July 1, 2025

Enrollment Period

6 months

First QC Date

July 31, 2025

Last Update Submit

August 9, 2025

Conditions

Osteoporosis

Keywords

YogaBone mineral densityBone metabolism

Outcome Measures

Primary Outcomes (1)

  • bone mineral density

    assessed by dual-energy X-ray absorptiometry (DXA, HOLOGIC Discovery Wi, Bedford, MA, USA), at lumbar spine and bilateral hips. Osteoporosis was diagnosed according to the World Health Organization criteria based on T-scores.

    baseline and 4 month

Secondary Outcomes (5)

  • N-MID Osteocalcin

    baseline and 4 month

  • Procollagen 1 N-terminal Propeptide

    baseline and 4 month

  • β-terminal telopeptide of I collagen (β-CTx)

    baseline and 4 month

  • 25-hydroxyvitamin D

    baseline and 4 month

  • Lower Limb Major Muscle Group Strength (Quadriceps Femoris, HamstringsTriceps Surae, Tibialis Anterior, lliopsoas)

    Baseline, 2 Months Post-ntervention, and 4 Months Post-Intervention

Study Arms (2)

experimental group

EXPERIMENTAL

Participants in the yoga intervention group attended supervised yoga classes twice per week for 16 weeks. Each yoga session lasted approximately 60 minutes and was conducted by certified yoga instructors. Sessions comprised breathing exercises, structured yoga postures, and relaxation. Heart rate was monitored regularly during sessions to maintain appropriate intensity.

Behavioral: Yoga

control group

NO INTERVENTION

Participants in the control group were instructed to maintain their usual activities and not initiate any new structured exercise programs during the study period

Interventions

YogaBEHAVIORAL

: Participants in this arm received a structured yoga course intervention for a period of 4 months. Sessions were held twice weekly, with each lasting 60 minutes. The curriculum was specifically designed to be gentle, slow-paced, and low-impact, making it suitable for older adults while emphasizing body awareness, mind-body integration, and psychological regulation. The course content included: breathing exercises (e.g., basic abdominal breathing combined with simple movements), asana (posture) practice (e.g., seated chair exercises, standing poses, prone poses, supine poses, and side-lying poses, emphasizing muscle activation, joint flexibility, bodybalance training, and coordination of breath with movement), and meditation and relaxation (e.g.supine rest, moon breath training, and OM chanting). All classes were instructed by experienced yoga teachers certified by the Yoga Alliance.

experimental group

Eligibility Criteria

Age50 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • age ≥50 years;
  • diagnosed with osteoporosis using dual-energy X-ray absorptiometry (DXA);
  • able to independently perform required assessments;
  • voluntary participation in yoga intervention.

You may not qualify if:

  • secondary osteoporosis;
  • severe cardiovascular, cerebrovascular, hepatic, or renal diseases;
  • cognitive impairment;
  • severe motor dysfunction;
  • regular participation in structured exercise programs, such as yoga or resistance training, within the past six months.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Beijing Sport University

Beijing, Beijing Municipality, 100091, China

Location

MeSH Terms

Conditions

Osteoporosis

Interventions

Yoga

Condition Hierarchy (Ancestors)

Bone Diseases, MetabolicBone DiseasesMusculoskeletal DiseasesMetabolic DiseasesNutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Mind-Body TherapiesComplementary TherapiesTherapeuticsSpiritual TherapiesExercise Movement TechniquesPhysical Therapy Modalities

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 31, 2025

First Posted

August 15, 2025

Study Start

July 1, 2024

Primary Completion

December 31, 2024

Study Completion

December 31, 2024

Last Updated

August 15, 2025

Record last verified: 2025-07

Locations

CN(1)