Perioperative Database of Chinese Elderly Patients for Postoperative Acute Kidney Injury

NCT06462755 | Completed

• 1 other identifier: PLAGH-AOC-R01
• Study Type: observational
• Target: 57,089
• Locations: 0 countries
• Sites: N/A

Brief Summary

To develop and externally validate a risk prediction model for postoperative acute kidney injury (PO-AKI) in elderly patients undergoing major noncardiac surgery, addressing the current gap in predictive tools for this vulnerable population. The endpoint was the occurrence of PO-AKI within seven days following surgery. Diagnoses were based on the Kidney Disease: Improving Global Outcomes (KDIGO) criterion. Potential PO-AKI-related perioperative data were retrieved and extracted from electronic medical record for model derivation and validation. Clinicians may consider implementing this externally validated risk prediction model to stratify elderly patients' PO-AKI risks in the early postoperative phases of noncardiac surgery in elderly patients.

Conditions

Postoperative Acute Kidney Injury

Outcome Measures

Primary Outcomes (1)

• Number of participants with postoperative acute kidney injury

  Postoperative acute kidney injury

  within seven days following surgery

Study Arms (1)

elderly patients (aged ≥ 65 years)

elderly patients undergo surgeries

Other: No intervention

Interventions

No intervention OTHER

no intervention

elderly patients (aged ≥ 65 years)

Eligibility Criteria

• Age: 65 Years - 120 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Elderly patients (aged ≥ 65 years) undergoing non-cardiac surgeries

You may qualify if:

• elderly patients (aged ≥ 65 years) undergoing non-cardiac surgeries

You may not qualify if:

• (1) Patients who underwent endoscopic or transplant procedures;
• (2) Patients who underwent surgeries lasting longer than 10 hours;
• (3) Patients who had severe preoperative kidney dysfunction, defined as preoperative sCr levels ≥ 353.6 μmol/L, or a baseline estimated Glomerular Filtration Rate (eGFR) \< 15 ml/min per 1.73 m2;
• (4) Patients without sCr values at baseline or during follow-up to detect PO-AKI occurrences.

Sponsors & Collaborators

• Chinese PLA General Hospital: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director (Cheif expert of National key research and development program of China 2018YFC2001900)

Study Record Dates

• First Submitted: June 12, 2024
• First Posted: June 17, 2024
• Study Start: January 1, 2009
• Primary Completion: December 31, 2018
• Study Completion: December 31, 2018
• Last Updated: July 8, 2024

Record last verified: 2024-07