Preoperative Inflammatory Status and Postoperative Acute Kidney Injury

NCT06027476 | Completed

• 1 other identifier: TJH-20230608B
• Study Type: observational
• Target: 8,472
• Locations: 1 country
• Sites: 1

Brief Summary

Acute kidney injury (AKI) is a common complication during the early postoperative period after noncardiac surgery. Patients with AKI are at an increased risk of developing chronic kidney disease, prolonging hospitalization, and experiencing higher rates of morbidity and mortality. Identifying preoperative risk factors for postoperative AKI can significantly contribute to the development of preventive strategies and improved perioperative care in this vulnerable patient population. The goal of this retrospective study is to investigate the predictive value of preoperative inflammatory status, as measured by complete blood count-derived inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), derived neutrophil-to-lymphocyte ratio (dNLR), neutrophil-to-lymphocyte\*platelet ratio (NLPR), systemic immune-inflammatory index (SII), systemic inflammatory response index (SIRI), and aggregate index of systemic inflammation (AISI), on postoperative AKI in elderly patients undergoing non-cardiac surgery.

Conditions

Postoperative Acute Kidney Injury

Outcome Measures

Primary Outcomes (1)

• Number of participants with acute kidney injury after surgery

  In accordance with the KDIGO creatinine criteria: a serum creatinine increases of 26.5 mmol/L within 48 hours or 1.5 times baseline within 7 days after surgery.

  Within 7 days after surgery

Eligibility Criteria

• Age: 65 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Elderly patients (aged ≥ 65 years) who underwent a non-cardiac surgery at Tongji Hospital between July 2018 and December 2021 were included in our study.

You may qualify if:

• aged ≥ 65 years.
• general, gynaecological, neurosurgery, orthopaedic, or thoracic surgery.
• surgery duration lasting longer than one hour.

You may not qualify if:

• patients with an American Society of Anesthesiologists (ASA) physical status V.
• those with concurrent cardiac, vascular, transplant or urological surgeries.
• those with end-stage renal disease (i.e. a glomerular filtration rate of 15 mL/min/1.73 m2 or receiving haemodialysis) or a history of kidney transplantation..
• those did not have sufficient data required for calculation for inflammatory markers or AKI evaluation.

Sponsors & Collaborators

• Rao Sun: lead

Study Sites (1)

Rao Sun

Wuhan, China

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate chief physician

Study Record Dates

• First Submitted: August 30, 2023
• First Posted: September 7, 2023
• Study Start: September 10, 2023
• Primary Completion: October 1, 2023
• Study Completion: October 5, 2023
• Last Updated: November 22, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)