Predictive Nomogram for Postoperative Acute Kidney Injury (AKI) in Elderly Patients Following Liver Resection

NCT04922866 | Completed DMC

• 1 other identifier: PLAGH-AOC-002
• Study Type: observational
• Target: 843
• Locations: 1 country
• Sites: 2

Brief Summary

Acute kidney injury (AKI) is a severe complication after liver resection and is associated with morbidity and mortality. The incidence of postoperative AKI is significantly higher in elderly patients, especially in those with comorbidities. There is currently limited evidence on the incidence and associations of postoperative AKI in elderly patients following liver resection. This study will evaluate the incidence and associations of AKI in elderly patients after liver resection and its impact on postoperative mortality.

Conditions

Postoperative Acute Kidney Injury

Keywords

acute kidney injury; predictive nomogram; elderly; liver resection

Outcome Measures

Primary Outcomes (1)

• Postoperative acute kidney injury

  Postoperative acute kidney injury is defined as an absolute increase in serum creatinine of 0.3 mg/dl within 48 hours or a 1.5-fold increase from preoperative baseline within seven days after surgery, according to the Kidney Disease: Improving Global Outcomes (KDIGO) criterion.

  postoperative seven days

Secondary Outcomes (1)

• Incidence of postoperative AKI

  postoperative seven days

Study Arms (1)

elderly patients following hepatectomy

elderly patients (aged ≥65 years) scheduled for any type of liver resection

Other: no intervention

Interventions

no intervention OTHER

no intervention

elderly patients following hepatectomy

Eligibility Criteria

• Age: 65 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Elderly patients (aged ≥ 65 years) with benign and malignant liver diseases of the Chinese PLA General Hospital HPB (Hepato-Pancreato-Biliary) Center undergoing liver resection from 2012-2019

You may qualify if:

• Elderly patients aged ≥65 years
• Benign and malignant liver diseases

You may not qualify if:

• Emergency operation
• Liver transplantation

Sponsors & Collaborators

• Chinese PLA General Hospital: lead

Study Sites (2)

Chinese PLA General Hospital

Beijing, Beijing Municipality, China

Location

Chinese PLA General Hospital

Beijing, 100089, China

Location

Related Publications (1)

• Yu Y, Zhang C, Zhang F, Liu C, Li H, Lou J, Xu Z, Liu Y, Cao J, Mi W. Development and validation of a risk nomogram for postoperative acute kidney injury in older patients undergoing liver resection: a pilot study. BMC Anesthesiol. 2022 Jan 13;22(1):22. doi: 10.1186/s12871-022-01566-z.

  PMID: 35026992 DERIVED

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Weidong Mi, PhD

  Chinese PLA General Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director (Cheif expert of National key research and development program of China 2018YFC2001900)

Study Record Dates

• First Submitted: June 7, 2021
• First Posted: June 11, 2021
• Study Start: September 1, 2020
• Primary Completion: January 30, 2022
• Study Completion: January 30, 2022
• Last Updated: March 11, 2022

Record last verified: 2022-03

Locations

CN (2)