Acute Lung Injury After Cardiac Surgery: Pathogenesis
ALI
1 other identifier
observational
50
0 countries
N/A
Brief Summary
The purpose of the present study is to visualize the inflammatory response and coagulation disorders during cardiac surgery in order to identify possible predictors for acute lung injury postoperatively.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Sep 2008
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2009
CompletedFirst Submitted
Initial submission to the registry
May 21, 2015
CompletedFirst Posted
Study publicly available on registry
June 19, 2015
CompletedJune 19, 2015
June 1, 2015
6 months
May 21, 2015
June 16, 2015
Conditions
Outcome Measures
Primary Outcomes (1)
Acute lung injury measured as the fraction of partial pressure of oxygen divided by the fraction of inspired oxygen
Arterial blood gas analysis
Evaluated 72 hours after weaning from cardiopulmonary bypass (CPB)
Secondary Outcomes (14)
Interleukin-1beta
The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB
Interleukin-2
The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB
Interleukin-4
The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB
Interleukin-6
The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB
Interleukin-8
The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB
- +9 more secondary outcomes
Interventions
No treatment
Eligibility Criteria
Patients scheduled for elective coronary artery bypass grafting (CABG)
You may qualify if:
- Elective surgery
- CABG
- In treatment with statins
You may not qualify if:
- Acute surgery
- Valve replacement
- In treatment with immunodepressive drugs
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Aalborg University Hospitallead
- Aalborg Universitycollaborator
Biospecimen
Plasma samples stored at -80 degrees of Celcius
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Bodil S Rasmussen, MD, PhD
Aalborg University Hospital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor, PhD
Study Record Dates
First Submitted
May 21, 2015
First Posted
June 19, 2015
Study Start
September 1, 2008
Primary Completion
March 1, 2009
Study Completion
March 1, 2009
Last Updated
June 19, 2015
Record last verified: 2015-06