Peanuts and Neurocognitive / Cardiovascular Health in Black Individuals

NCT06318377 | Completed DMC

• 1 other identifier: 2022-0541
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The overall research objective of this proposal is to determine the impact of increased daily peanut consumption on indices of neurocognitive and physiological health in BL individuals

Conditions

Cardiovascular Diseases; Hypertension; Cognitive Decline; Diet; Healthy

Keywords

endothelial function; brain blood flow; cognition

Outcome Measures

Primary Outcomes (10)

• Endothelial Function

  Flow medicated dilation of the brachial artery

  baseline & following 8 weeks of daily peanut consumption

• Neurocognitive Function

  Performance on the NIH Toolbox Cognitive battery

  baseline & following 8 weeks of daily peanut consumption

• Systolic blood pressure in brachial artery (mmHg)

  standard blood pressure measures

  baseline & following 8 weeks of daily peanut consumption

• Plasma concentration of total Cholesterol (Total-C)

  assessment of total Cholesterol (Total-C)

  baseline & following 8 weeks of daily peanut consumption

• Arterial stiffness

  assessment of pulse wave velocity and pulse wave analysis

  baseline & following 8 weeks of daily peanut consumption

• Diastolic blood pressure in brachial artery(mmHg)

  standard blood pressure measures

  baseline & following 8 weeks of daily peanut consumption

• Mean blood pressure in brachial artery (mmHg)

  standard blood pressure measures 9(mmHg)

  baseline & following 8 weeks of daily peanut consumption

• Plasma concentration of Low density lipoprotein (LDL)

  assessment of Low density lipoprotein (LDL)

  baseline & following 8 weeks of daily peanut consumption

• Plasma concentration of High density lipoprotein (HDL)

  assessment of High density lipoprotein (HDL)

  baseline & following 8 weeks of daily peanut consumption

• Plasma concentration of Very Low density lipoprotein (VLDL)

  assessment of Very Low density lipoprotein (VLDL)

  baseline & following 8 weeks of daily peanut consumption

Study Arms (2)

Peanut Consumption

EXPERIMENTAL

Peanuts are rich in polyphenols and also have anti-inflammatory and antioxidant properties.

Dietary Supplement: Peanut group

Non-peanut consumption

NO INTERVENTION

The non-peanut consumption will simply not be consuming any additional supplements in their diet

Interventions

Peanut group DIETARY_SUPPLEMENT

These are commercially available peanuts that are high in antioxidants and are believed to be beneficial for physiological health

Peanut Consumption

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Individuals that self-identify as white or black and who have at least one biological parent who identifies as their own self-identified race/ethnicity will be included in this study. Both men and women will be included in this study. Individuals must be between the ages of 18-50.

You may not qualify if:

• Individuals with peanut allergy
• Individuals in hypertensive crisis
• Pregnant women
• Breast feeding
• Allergies to spandex/lycra

Sponsors & Collaborators

• The University of Texas at Arlington: lead

Study Sites (1)

UT Arlington - Science and Engineering Innovation and Research Building

Arlington, Texas, 76019, United States

Location

MeSH Terms

Conditions

Cardiovascular Diseases; Hypertension; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Vascular Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Robert M Brothers, PhD

  University of Texas at Arlington

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Individual will be randomly assigned either an experimental or a control condittion

Study Record Dates

• First Submitted: March 12, 2024
• First Posted: March 19, 2024
• Study Start: September 1, 2022
• Primary Completion: July 31, 2024
• Study Completion: July 31, 2024
• Last Updated: April 1, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)