The Influence of Acute Moderate-intensity Continuous Exercise on Appetite Regulation

NCT06296511 | Completed

• 1 other identifier: Loughborough University
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

A key area of obesity research has focused on the link between appetite, energy balance and weight control. Within this area, several appetite-related hormones and cellular cytokines have been identified as key signals influencing appetite and food intake. This includes the appetite-suppressing hormone oxyntomodulin (OXM) and a cellular stress-induced cytokine growth differentiation factor 15 (GDF-15). The aims of this study are: (1) to investigate the effect of acute moderate-intensity continuous exercise on oxyntomodulin and GDF-15 concentrations; (2) to investigate whether exercise-induced changes in circulating OXM and GDF-15 concentrations are correlated with subjective appetite perceptions and subsequent energy intake.

Conditions

Obesity; Overweight

Keywords

Exercise; Appetite; Oxyntomodulin; Growth differentiation factor 15; GDF-15

Outcome Measures

Primary Outcomes (2)

• Oxyntomodulin

  (pmol/L)

  Blood samples were collected for oxyntomodulin measurements at 0 (baseline), 60, 90, 120, 150, 180, 210 minutes in each trial.

• Growth Differentiation Factor 15

  (pg/mL)

  Blood samples were collected for GDF-15 measurements at 0 (baseline), 60, 90, 120, 150, 180, 210 minutes in each trial.

Secondary Outcomes (2)

• Visual analogue score (VAS) for subjective appetite

  VAS was measured at 0 (baseline), 60, 90, 120, 150, 180, 210 minutes in each trial.

• Energy intake

  Ad libitum pasta meal provided at 120 minutes.

Study Arms (2)

Exercise

EXPERIMENTAL

Participants were asked to arrive at the lab at 8.30 am, having fasted overnight for 10 hours. After resting in the lab for 30 minutes, participants were asked to exercise at an intensity of 70 percent of their peak oxygen uptake for an hour before resting in the lab for a further 2.5 hours. Ad libitum energy intake was assessed 1 h after exercise completion.

Behavioral: Exercise

Control

NO INTERVENTION

Participants replicated all the procedures of the exercise trial except they rested for 1 h as the exercise counterpart.

Interventions

Exercise BEHAVIORAL

60 min of treadmill exercise performed at 70% of peak oxygen uptake.

Exercise

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Body mass index between 18.5-24.9 kg/m²;
• Habitually consume three meals a day;
• Able to run continuously for 1 hour;
• Not currently dieting and weight stable for 3 months (\< 3 kg change in weight);
• No severe dislike or allergy to any of the study food;
• Regular menstrual cycle in the past 6 months.

You may not qualify if:

• Smokers (vaping is considered smoking in this study);
• Individuals with medical conditions (e.g., diabetes, heart condition);
• Individuals taking medications that may influence the study outcomes;
• Individuals with clinically diagnosed eating disorders.

Sponsors & Collaborators

• Loughborough University: lead

Study Sites (1)

Loughborough University

Loughborough, LE11 3TU, United Kingdom

Location

MeSH Terms

Conditions

Obesity; Overweight; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• David J Stensel

  Loughborough University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 29, 2024
• First Posted: March 6, 2024
• Study Start: June 23, 2023
• Primary Completion: November 7, 2023
• Study Completion: November 7, 2023
• Last Updated: March 6, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will share

Locations

GB (1)