The Influence of Acute Continuous Exercise and Adiposity on Appetite Hormones and Neural Correlates of Visual Food Cues

NCT06849050 | Completed

• 1 other identifier: 18581
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Exercise increases energy expenditure and impacts appetite and energy intake. Some appetite-related hormones such as oxyntomodulin suppress appetite whilst other hormones such as ghrelin stimulate appetite. This study will investigate whether acute continuous walking/jogging influences these hormone concentrations, and whether exercise-induced changes in the hormones correlate with perceptions of appetite, nutritional intake and brain activity in individuals varying in weight status.

Conditions

Overweight; Obesity

Keywords

Appetite; Obesity; Overweight; fMRI; Neural correlates; Exercise; Oxyntomodulin

Outcome Measures

Primary Outcomes (1)

• Concentration of Oxyntomodulin

  Plasma blood samples

  Blood samples to measure oxyntomodulin are collected at 30-minute intervals (0 hours [08:30], 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 3.5 hours and 4 hours) in each trial.

Secondary Outcomes (11)

• Concentration of Acylated Ghrelin

  Blood samples to measure acylated ghrelin are collected at 30-minute intervals (0 hours [08:30], 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 3.5 hours and 4 hours) in each trial.

• Concentration of Leptin

  Blood samples to measure leptin are collected at 0 hours [08:30] in each trial.

• Concentration of Glucagon-like peptide 1

  Blood samples to measure GLP-1 are collected at 30-minute intervals (0 hours [08:30], 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 3.5 hours and 4 hours) in each trial.

• Concentration of Peptide YY

  Blood samples to measure PYY are collected at 30-minute intervals (0 hours [08:30], 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 3.5 hours and 4 hours) in each trial.

• Concentration of Glucose

  Blood samples to measure glucose are collected at 30-minute intervals (0 hours [08:30], 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 3.5 hours and 4 hours) in each trial.

Study Arms (2)

Control

NO INTERVENTION

Rest in the laboratory from 08:00 to 13:00. For 30-minutes, participants will be asked to wear a face mask, which will measure their oxygen consumption at rest. Ad libitum energy intake assessed at 11:00 (2.5 hours).

Exercise

EXPERIMENTAL

Rest in the laboratory from 08:00 to 13:00 apart from 60 minutes of treadmill exercise (walking/jogging) performed between 09:00-10:00 (0.5-1.5 hours). Ad libitum energy intake assessed at 11:00 (2.5 hours).

Behavioral: Acute continuous exercise

Interventions

Acute continuous exercise BEHAVIORAL

Exercise, which will involve 60 minutes of brisk walking, or jogging, at 60% of peak oxygen uptake. Participants will be asked to wear a face mask, which will measure their oxygen consumption during the exercise session.

Exercise

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Body mass index (BMI) between 18.5 - 24.9 kg/m2 and a waist circumference of ≤ 88 cm for women, and ≤ 102 cm for men or a BMI between 25 - 40 kg/m2 and a waist circumference of \> 88 cm for women, and \> 102 cm for men. BMI and waist circumference thresholds vary amongst ethnicities. People with a South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean family background are prone to central adiposity and their cardiometabolic risk occurs at a lower BMI. Therefore, the following BMI and waist circumference thresholds will be applied for people of South Asian, other Asian, Black African and African-Caribbean ethnicity: (1) BMI 18.5 kg/m2 to 23 kg/m2 and waist circumference of \< 90 cm for men and \< 80 cm for women; (2) BMI 23.1 kg/m2 to 40 kg/m2 and waist circumference of ≥ 90 cm for men and ≥ 80 cm for women.
• Normally consumes three meals a day
• Able to walk continuously for 1 hour on a treadmill
• Weight stable for 3 months (\< 3kg change in weight)
• Regular menstrual cycle for the last 6 months (people taking the combined contraceptive pill are eligible for the study)
• Able to undergo a 45-minute MRI scan

You may not qualify if:

• Smokers (vaping is considered smoking in this study)
• Known medical conditions (e.g. diabetes, heart condition)
• Taking any medication which may affect the study outcomes (e.g. liraglutide, semaglutide, insulin, steroids, anti-psychotics)
• Clinically diagnosed eating disorder
• Previous bariatric surgery (e.g. gastric bypass, gastric band, sleeve gastrectomy)
• Food allergies or intolerances, or severe dislikes to study foods
• Pregnant or breastfeeding
• Have recently donated blood (within eight weeks of visits 2 and 3).

Sponsors & Collaborators

• Loughborough University: lead

Study Sites (1)

Loughborough University

Loughborough, United Kingdom

Location

MeSH Terms

Conditions

Overweight; Obesity; Motor Activity

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Study Officials

• David J Stensel

  Loughborough University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Exercise Metabolism

Study Record Dates

• First Submitted: February 18, 2025
• First Posted: February 27, 2025
• Study Start: July 5, 2024
• Primary Completion: September 3, 2025
• Study Completion: September 3, 2025
• Last Updated: September 10, 2025

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will share

Locations

GB (1)