Train Your Brain 2.0 - Improving Memory and Decision Making Among Youth

NCT06242704 | Recruiting

• 1 other identifier: B11256
• Study Type: interventional
• Target: 72
• Locations: 1 country
• Sites: 2

Brief Summary

The goal of this clinical trial is to deliver a computer-based working memory training program to improve delay discounting (DD) and prevent substance misuse among at-risk adolescents in a traditionally underserved area. Results from the study will inform future substance use prevention efforts targeted at youth exposed to adverse childhood experiences. Findings will also refine future models of intervention delivery in traditionally underserved communities. The main aims of the project are are: 1\) To examine to examine changes in hypothesized mechanisms of substance use initiation and escalation, and 2) to assess whether changes in DD are a mechanism for reducing substance misuse during early adolescence. The investigators will evaluate whether changes in DD following active treatment predict substance use outcomes over the three-month follow-up period.

Conditions

Behavior, Health

Keywords

delay discounting; computer-based intervention; executive functioning; substance use; working memory

Outcome Measures

Primary Outcomes (1)

• Change in Monetary Choice Questionnaire

  The Monetary Choice Questionnaire (MCQ) is a measure of delay discounting (DD). Participants will be presented with two choices, one with a small, immediate monetary reward and the other with a larger, delayed monetary reward. They will be required to choose one of those rewards and their responses will be scored using reference discounting curves. A calculated score that places participants on steeper curves indicates higher levels of impulsivity and higher rates of DD. Scores are not bounded with a minimum and maximum value, but higher scores indicate worse outcomes and demonstrate the participant's preference to gain smaller rewards immediately over larger rewards with a time delay.

  Baseline, 2 Weeks, 3 Months

Secondary Outcomes (8)

• Change in Consideration of Future Consequences Scale

  Baseline, 2 Weeks, 3 Months

• Change in Digit Span

  Baseline, 2 Weeks, 3 Months

• Change in Stop Signal Task

  Baseline, 2 Weeks, 3 Months

• Changes in Letter Number Sequencing Test

  Baseline, 2 Weeks, 3 Months

• Change in Alcohol Effect Expectancies (Breif)

  Baseline, 2 Weeks, 3 Months

Study Arms (2)

Working Memory Training

EXPERIMENTAL

The intervention is a computer-based training aimed at improving working memory in order to decrease delay discounting. Active training sessions include: Sequenced Recall of Digits - Auditory, Sequenced Reverse Recall of Digits - Auditory, Sequenced Recall of Digits - Visual, Sequenced Reverse Recall of Digits - Visual, Sequenced Recall of Words - Auditory, Sequenced Recall of Words - Visual, Sequenced Reverse Recall of Words - Auditory, Sequenced Reverse Recall of Words - Visual. Participants will complete at least 10 sessions with each session taking approximately 30 minutes to complete.

Behavioral: Working Memory Training

Working Memory

ACTIVE COMPARATOR

The comparison control condition is a multi-session control computer training condition that is designed to not engage working memory during computer-based engagement sessions: Sequenced Recall of Digits - Auditory, Sequenced Reverse Recall of Digits - Auditory, Sequenced Recall of Digits - Visual, Sequenced Reverse Recall of Digits - Visual, Sequenced Recall of Words - Auditory, Sequenced Recall of Words - Visual, Sequenced Reverse Recall of Words - Auditory, Sequenced Reverse Recall of Words - Visual. Participants will complete at least 10 sessions with each session taking approximately 30 minutes to complete.

Behavioral: Working Memory

Interventions

Working Memory Training BEHAVIORAL

A multi-session computer-based working memory training program to improve delay discounting and prevent substance use among at-risk adolescents in a traditionally underserved area.

Working Memory Training

Working Memory BEHAVIORAL

A multi-session control computer training condition that is designed to not engage working memory among at-risk adolescents in a traditionally underserved area.

Working Memory

Eligibility Criteria

• Age: 11 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Between the ages of 11 and 15 and have a parent/guardian willing to provide consent for their participation
• Proficient in English
• Willing to commit to participate in computer-based trainings over the course of 5-8 weeks (duration dependent on site)
• Access to internet services, cell phone, and/or email
• Willing to receive/send study-related text messages

You may not qualify if:

• Self-disclosure or identification with psychological disturbance, suicidality, or evidence of active suicide ideation
• Self-disclosure of current substance use disorder
• Provide consent for child's participation in study
• Proficient in English
• Access to internet services, cell phone, and/or email
• Willing to receive/send study-related text messages
• Self-disclosure or identification with psychosis, suicidality, or evidence of active suicide ideation
• Self-disclosure of current substance use disorder

Sponsors & Collaborators

• Wayne State University: lead

Study Sites (2)

Freedom Schools Collaborative

Flint, Michigan, 48504, United States

RECRUITING

Ernest T. Ford Recreation Center

Highland Park, Michigan, 48203, United States

RECRUITING

MeSH Terms

Conditions

Health Behavior; Substance-Related Disorders

Condition Hierarchy (Ancestors)

Behavior; Chemically-Induced Disorders; Mental Disorders

Central Study Contacts

Julia Felton, PhD

CONTACT

7049957832; Jfelton4@hfhs.org

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 16, 2024
• First Posted: February 5, 2024
• Study Start: June 25, 2024
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: May 25, 2025

Record last verified: 2025-05

Locations

US (2)