Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions
Acute and Chronic Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions on Muscle Strength, Thickness, Catecholamine, and Inflammatory Responses in Physically Active Adults
1 other identifier
interventional
60
1 country
1
Brief Summary
One approach to significantly reducing resistance training intensity while maintaining effectiveness in muscle mass and strength development involves conducting training sessions under hypoxic conditions. This is likely due to heightened physiological responses. While sports science research indicates a substantial impact of hypoxic conditions on immediate increases in metabolic stress and augmented hormonal responses, recent findings suggest that the role of their influence on skeletal muscle adaptations post-resistance training under hypoxic conditions remains unknown. Additionally, there is a lack of reports on whether the type of hypoxia applied via blood flow restriction or chamber differentiates the increase in secretion of these catecholamines in both immediate and long-term aspects.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Nov 2023
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 20, 2023
CompletedFirst Submitted
Initial submission to the registry
November 25, 2023
CompletedFirst Posted
Study publicly available on registry
December 15, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 20, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2024
CompletedJune 11, 2024
June 1, 2024
7 months
November 25, 2023
June 10, 2024
Conditions
Outcome Measures
Primary Outcomes (8)
Force Output
Force plate will be used to quantify maximum absolute (N) and relative force output (body mass divided per force output in N/kg) during maximum voluntary isometric back squat in a 100ms time frame. Participants will be pushing as hard and as fast as they can on an unmoveable barbell while standing on a force plate.
Immediately pre and post first and last training session
One-Repetition Maximum
One-Repetition Maximum test in leg press exercise will be performed to quantify maximum lower body dynamic strength (kg). Participants will be performing single repetitions of leg press exercise with increasing load until volitional failure.
within 5 days from the start and end of training
Maximum Number of Repetitions
A maximum number of repetitions in leg press exercise will be performed to quantify lower body strength endurance (number). Participants will be performing leg press exercise at 50% of one-repetition maximum until volitional failure.
within 5 days from the start and end of training
Countermovement Jump Height
Countermovement jump height will be performed estimated via take-off velocity performed on force plates to Participants will perform 3 trials on force plate.
Immediately pre and post first and last training session
Countermovement Jump Power Output
Countermovement jump performance will be performed to quantify maximum lower body relative and absolute power-output (W/kg and W), and jump height (cm) with concomitant assessment of contraction depth (cm) and contraction time (ms). Participants will perform 3 trials on force plate.
Immediately pre and post first and last training session
Catecholamine Response
A blood sample will be analyzed to quantify changes in epinephrine and norepinephrine level changes.
Immediately pre and post first and last training session
Muscle Stiffness
Myotonometry measure will be used to quantify changes in vastus medialis oblique muscle stiffness in N/m
Immediately pre and post first and last training session
Muscle Thickness
Ultrasonography measure will be used to quantify changes in vastus medialis oblique cross-sectional area.
within 5 days from the start and end of training
Secondary Outcomes (3)
Perception of Pain
Immediately pre and post every training session
Perception of Effort
Immediately pre and post every training session
Blood Pressure
Immediately pre and post first and last training session
Other Outcomes (4)
Total Body Mass
within 5 days from the start and end of training
Percentage Body Fat
within 5 days from the start and end of training
Bone Mass Density
within 5 days from the start and end of training
- +1 more other outcomes
Study Arms (5)
Low-Intensity Normoxia
ACTIVE COMPARATORParticipants will be breathing room air, and perform low-intensity lower-body resistance exercise.
High-Intensity Normoxia
ACTIVE COMPARATORParticipants will be breathing room air, and perform high-intensity lower-body resistance exercise.
Low-Intensity Normoxia with Blood Flow Restriction
EXPERIMENTALParticipants will be breathing room air, and perform low-intensity lower-body resistance exercise combined with blood flow restriction.
Low-Intensity Hypoxia
EXPERIMENTALParticipants will be breathing a 13% oxygen gas mixture, and perform low-intensity lower-body resistance exercise.
Low-Intensity Hypoxia with Blood Flow Restriction
EXPERIMENTALParticipants will be breathing a 13% oxygen gas mixture, and perform low-intensity lower-body resistance exercise combined with blood flow restriction.
Interventions
4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in normoxic conditions performed twice a week for 6 weeks.
4 sets of 10 repetitions of leg press exercise at 70-80% one-repetition maximum (weeks 1-3: 70%, weeks 4-6: 80%) in normoxic conditions performed twice a week for 6 weeks.
4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in normoxic conditions with lower-limbs blood flow restriction (80% total occlusion pressure) performed twice a week for 6 weeks.
4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in hypoxia conditions (3500 meters above sea) performed twice a week for 6 weeks.
4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in normobaric hypoxia conditions (3500 meters above sea) with lower-limbs blood flow restriction (80% total occlusion pressure) performed twice a week for 6 weeks.
Eligibility Criteria
You may qualify if:
- Regularly physically active (at least 30 mins of structured exercise 3 times per week),
- Sea-level natives,
- Experienced in resistance training (at least one year of experience in regular resistance exercise)
You may not qualify if:
- presence of any medical risk factors to exercise and/or exposure to altitude
- presence of any medical condition that would make the protocol unreasonably hazardous for the participant
- smokers
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
The Jerzy Kukuczka Academy of Physical Education
Katowice, Silesian Voivodeship, 40-065, Poland
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
November 25, 2023
First Posted
December 15, 2023
Study Start
November 20, 2023
Primary Completion
June 20, 2024
Study Completion
July 1, 2024
Last Updated
June 11, 2024
Record last verified: 2024-06