Effects of Blood Flow Restriction vs. High-Load Resistance Training on Arm Strength

NCT07462520 | Completed

• 1 other identifier: E-77082166-302.08.01-506408
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigated the effects of low-load resistance training combined with blood flow restriction (BFRT) compared to traditional high-load resistance training on arm muscle strength and isokinetic contraction parameters in healthy young adults. Participants were prospectively assigned to either a low-load BFRT group or a high-load resistance training group for a 7-week intervention period. Muscle strength and isokinetic peak torque were assessed before and after the intervention. The primary objective was to determine whether low-load BFRT produces comparable improvements in muscle strength and isokinetic performance to high-load resistance training.

Conditions

Muscle Strength; Resistance Training; Blood Flow Restriction

Keywords

Blood flow restriction; Resistance exercise; Isokinetic contraction; Muscle strength; Peak Torque

Outcome Measures

Primary Outcomes (1)

• Arm Muscle Strength

  Isokinetic peak torque of elbow flexor and extensor muscles measured using an isokinetic dynamometer.

  Baseline and after 7 weeks of training

Secondary Outcomes (1)

• Isokinetic Contraction Parameters

  Baseline and after 7 weeks of training

Study Arms (2)

Low-Load Blood Flow Restriction Training(LL-BFRT)

EXPERIMENTAL

Participants performed resistance exercises at 30% of one-repetition maximum combined with individualized blood flow restriction pressure for 7 weeks.

Procedure: Low Load Blood Flow Restriction Training

High-Load Resistance Training(HL-RT)

ACTIVE COMPARATOR

Participants performed resistance exercises at 70% of one-repetition maximum without blood flow restriction for 7 weeks.

Procedure: High Load Resistance Training

Interventions

Low Load Blood Flow Restriction Training PROCEDURE

Low-load resistance training performed at 30% of one-repetition maximum with individualized blood flow restriction pressure.

Low-Load Blood Flow Restriction Training(LL-BFRT)

High Load Resistance Training PROCEDURE

Traditional resistance training performed at 70% of one-repetition maximum without blood flow restriction.

High-Load Resistance Training(HL-RT)

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy individuals between the ages of 18 and 40
• Individuals not taking any dietary supplements
• Individuals not taking a substance containing anabolic ingredients
• Individuals subjected to a resistance training program for at least 6 months
• Individuals not performing aerobic training for more than 30 minutes per day
• Individuals training with a personal trainer

You may not qualify if:

• Individuals with a skeletal muscle injury in the last 6 months
• Individuals who have undergone a surgical operation
• Individuals with chronic high blood pressure and cardiovascular disease
• Individuals who miss three consecutive training sessions
• Individuals with chronic cardiovascular disease

Sponsors & Collaborators

• Gazi University: lead

Study Sites (1)

Gazi University

Ankara, Turkey (Türkiye)

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: This was an open-label study. No masking was applied to participants, investigators, or outcome assessors.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer Phd.

Model Details: Participants were prospectively assigned to one of two parallel groups: a low-load blood flow restriction training group or a high-load resistance training group. Both groups completed a 7-week intervention, and outcomes were assessed pre- and post-intervention.

Study Record Dates

• First Submitted: March 5, 2026
• First Posted: March 10, 2026
• Study Start: February 5, 2024
• Primary Completion: March 25, 2024
• Study Completion: April 1, 2024
• Last Updated: March 12, 2026

Record last verified: 2026-03

Locations

TU (1)