Eccentric Resistance Training With Blood Flow Restriction on Muscle Function

NCT04977804 | Withdrawn

• 1 other identifier: 12042b
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The study will determine the effects of adding blood flow restriction to eccentric training to assess whether this increases the improvements of muscle strength and size.

Conditions

Blood Flow Restriction

Keywords

resistance training; muscle function; quadriceps; eccentric strength; vertical jump; muscle quality; muscle hypertrophy; eccentric training

Outcome Measures

Primary Outcomes (4)

• Eccentron maximal muscle strength

  Eccentric muscle strength will be assessed via Eccentron (BTE Technologies, Inc., USA), an seated isokinetic dynamometer.

  7 weeks

• Local muscle hypertrophy

  Muscle size changes of the quadriceps muscle measured an ultrasound device (GE NextGen LOGIQ, Tampa, Florida, USA).

  7 weeks

• Muscle mass

  dual energy x-ray absorptiometry device (DEXA) the Hologic Horizon W Dual X-ray absorptiometry (Hologic Canada ULC, Mississauga, ON, Canada) will be used to assess appendicular (lower body) mean mass.

  7 weeks

• Muscle function

  Vertical jump height will assess 3 maximal countermovement attempts on a jump mat (Just Jump Technologies, Huntsville, AL, USA) that measures jump height based on flight time.

  7 weeks

Secondary Outcomes (1)

• Muscle soreness

  7 weeks

Study Arms (2)

Eccentric only training

ACTIVE COMPARATOR

This is the experimental control; where this group will be used as the standard active comparison condition.

Other: Exercise

Eccentric plus blood-flow restriction

EXPERIMENTAL

This is the experimental condition involving the eccentric resistance training with blood flow restriction.

Other: Eccentric plus blood-flow restriction

Interventions

Eccentric plus blood-flow restriction OTHER

Eccentric plus blood-flow restriction

Eccentric plus blood-flow restriction

Exercise OTHER

The interventions are a form or exercise, specifically resistance exercise.

Eccentric only training

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• years of age
• currently engaged in some form of resistance training between 1-3 times per week
• must have been training aerobically, but no more than 3 hours a week for the past six months

You may not qualify if:

• Must not have had any surgery of the lower limbs within the past 1 year period
• Must not have any neuromuscular disorder (e.g., Muscular dystrophy etc.)
• \< 76 inches tall (in order to fit on the training machine)
• Maximal strength of \< 725 lbs for the eccentric training device
• If any of the subjects are pregnant or plan to be pregnant in the duration of the protocol.
• For those randomized to the BFR group, if any of the subject's thighs are too large for the BFR cuffs (greater than 68 cm).

Sponsors & Collaborators

• Utah State University: lead

Study Sites (1)

Utah State Universtiy

Logan, Utah, 84322, United States

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Brennan J Thompson, PhD

  Utah State Univeristy

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The person assessing the outcome measures will be blinded to the group designation of the subjects.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Two group, randomized parallel group design.

Study Record Dates

• First Submitted: July 20, 2021
• First Posted: July 27, 2021
• Study Start: March 30, 2024
• Primary Completion: June 1, 2025
• Study Completion: December 1, 2025
• Last Updated: December 7, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)