Effects of Blood Flow Restriction During Eccentric Resistance Exercise

NCT05606744 | Unknown

• 1 other identifier: 12042a
• Study Type: interventional
• Target: 45
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to compare the muscle strength and muscle soreness effects experienced following short term (acute) eccentric exercise with and without blood flow restriction (BFR) performed at low - moderate training intensities.

Conditions

Blood Flow Restriction

Outcome Measures

Primary Outcomes (10)

• visual analog scale (soreness)

  soreness

  Baseline (pretest)

• visual analog scale (soreness)

  soreness

  immediately post exercise

• visual analog scale (soreness)

  soreness

  24 hours post exercise

• visual analog scale (soreness)

  soreness

  48 hours post exercise

• visual analog scale (soreness)

  soreness

  72 hours post exercise

• force algometer (soreness)

  soreness

  Baseline (pretest)

• force algometer (soreness)

  soreness

  immediately post exercise

• force algometer (soreness)

  soreness

  24 hours post exercise

• force algometer (soreness)

  soreness

  48 hours post exercise

• force algometer (soreness)

  soreness

  72 hours post exercise

Secondary Outcomes (10)

• Eccentric muscle strength

  Baseline (pretest)

• Eccentric muscle strength

  immediately post exercise

• Eccentric muscle strength

  24 hours post exercise

• Eccentric muscle strength

  48 hours post exercise

• Eccentric muscle strength

  72 hours post exercise

Study Arms (2)

Eccentric exercise

ACTIVE COMPARATOR

Only multi-joint eccentric exercise

Device: Eccentric exercise / Eccentric exercise with blood flow restriction

Eccentric training with blood flow restriction

EXPERIMENTAL

Multi-joint eccentric exercise with blood flow restriction

Device: Eccentric exercise / Eccentric exercise with blood flow restriction

Interventions

Eccentric exercise / Eccentric exercise with blood flow restriction DEVICE

Individuals will be randomized to receive eccentric exercise only, or eccentric exercise with blood flow restriction.

Eccentric exercise; Eccentric training with blood flow restriction

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may not qualify if:

• lower body surgery or injury in the last 12 months
• have any neuromuscular disease
• height \>76 inches tall
• height \<54 inches tall
• eccentric strength greater than 725 pounds
• pregnant or plan to be pregnant in the duration of the protocol
• don't do resistance exercise at least once per week
• perform intense cardio or strength training \>4 days per week
• Present with any other significant comorbid conditions that would impair the ability to participate in the exercise-based testing
• years old
• strength train lower body 1-3 times per week

Sponsors & Collaborators

• Utah State University: lead

Study Officials

• Brennan Thompson, PhD

  Utah State University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Brennan J Thompson, PhD

CONTACT

435-797-5785; brennan.thompson@usu.edu

Sara Harper, PhD

CONTACT

435-797-1376; sara.harper@usu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Individuals will be randomly assigned to a BFR or non BFR exercise condition. The subjects will perform a single, 3-5 minute bout of eccentric exercise on the Eccentron device either with BFR (with restriction cuffs on the thigh per the procedures below) or without the BFR.

Study Record Dates

• First Submitted: October 13, 2022
• First Posted: November 7, 2022
• Study Start: June 1, 2023
• Primary Completion: December 1, 2023
• Study Completion: March 1, 2024
• Last Updated: November 7, 2022

Record last verified: 2022-11