Effects of Physical Training in Altered Environmental Conditions on Exercise Performance

NCT06159374 | Unknown

• 1 other identifier: MEIN 2021/DPI/229
• Study Type: interventional
• Target: 128
• Locations: 1 country
• Sites: 1

Brief Summary

The main objective of the study is to evaluate the physiological-biochemical effects of physical training under artificially altered climatic conditions (using a hypoxic thermoclimatic chamber) in particular to determine the effect of such training on exercise capacity and physiological response, including the effect of training in high-performance athletes. The study will evaluate the effects of physical training and the simultaneous application of hypoxia and heat/cold on aerobic and anaerobic capacity and the physiological response of the human body. The aim of the study is to find the most favourable environmental conditions for physical training in order to maximise physical performance.

Conditions

Hypoxia, Altitude; Cold Exposure; Heat Exposure

Keywords

training; exercise; human performance; aerobic capacity; anaerobic capacity; maximal oxygen uptake; muscle power

Outcome Measures

Primary Outcomes (3)

• Measurement of aerobic capacity (endurance)

  Measurement of maximal oxygen uptake and determination of ventilatory thresholds (ergospirometry)

  7 days before training and 7-10 days after the training. Training will last 4 weeks.

• Measurement of anaerobic capacity

  Measurement of maximal anaerobic power (Wingate Anaerobic Test)

  7 days before training and 7-10 days after the training. Training will last 4 weeks.

• Blood analysis

  indicators of muscle damage, inflammatory markers (interleukins), oxidative stress, lactate concentration, tissue oxygenation, selected hormones (including erythropoietin) and enzymes, HIF (hypoxia inducible factor), selected vitamins, morphology (including reticulocytes), rheology and blood biochemistry

  Before (10 min) and after (3 min) the first and last training. The training will last 4 weeks and will consist of 12 workouts

Study Arms (8)

Control

NO INTERVENTION

Control group

normoxia-thermoneutral

EXPERIMENTAL

Training performed under normoxia (200 m above sea level) and thermoneutral conditions (21°C) and constant humidity (40%);

Other: exercise and environmental conditions

hypoxia-thermoneutral

EXPERIMENTAL

Training performed under normobaric hypoxia (3000 m above sea level) and thermoneutral conditions (21°C) and constant humidity (40%);

Other: exercise and environmental conditions

normoxia-heat

EXPERIMENTAL

training performed under normoxia (200 m above sea level) and high ambient temperature (31°C) and constant humidity (40%);

Other: exercise and environmental conditions

hypoxia-heat

EXPERIMENTAL

training performed under normobaric hypoxia (3,000 m above sea level) and high ambient temperature (31°C) and constant humidity (40%);

Other: exercise and environmental conditions

normoxia-cold

EXPERIMENTAL

Training performed in normoxia (200 m above sea level) and low ambient temperature (-11°C) and constant humidity (40%).

Other: exercise and environmental conditions

hypoxia-cold

EXPERIMENTAL

training performed under normobaric hypoxia (3,000 m above sea level) and low ambient temperature (-11°C) and constant humidity (40%);

Other: exercise and environmental conditions

hypoxia-heat-humidity

EXPERIMENTAL

training performed under normobaric hypoxia (3,000 m above sea level) and high ambient temperature (31°C) and high humidity (70%);

Other: exercise and environmental conditions

Interventions

exercise and environmental conditions OTHER

Participants will perform interval training for 4 weeks in a variety of environmental conditions. There will be a measurement of aerobic and anaerobic capacity before and after the training. Before and after the first and last workout, blood will be drawn for biochemical analysis.

hypoxia-cold; hypoxia-heat; hypoxia-heat-humidity; hypoxia-thermoneutral; normoxia-cold; normoxia-heat; normoxia-thermoneutral

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• absence of medical contraindications to high-intensity physical exertion. The medical examination is required (included an exercise ECG, blood tests to exclude anemia or low hemoglobin and iron concentration)

You may not qualify if:

• any training (including hypoxia training or exposure) performed in the 6 months prior to the beginning of the intervention

Sponsors & Collaborators

• University School of Physical Education, Krakow, Poland: lead

Study Sites (1)

University School of Physical Education in Cracow

Krakow, 31-571, Poland

RECRUITING

MeSH Terms

Conditions

Altitude Sickness; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Marcin Maciejczyk, Prof. dr

  Departament of Physiology and Biochemistry

  STUDY DIRECTOR

Central Study Contacts

Anna Radoń, MSc

CONTACT

+45126831142; anna.radon@awf.krakow.pl

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 28, 2023
• First Posted: December 6, 2023
• Study Start: January 1, 2022
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2025
• Last Updated: December 13, 2023

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will not share

Locations

PL (1)