Effect of Collagen Peptides, in Combination With Resistance Training, on Body Composition and Muscle Strength in Untrained Men

NCT06061315 | Completed

• 1 other identifier: 7260992052
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The effect of resistance training with post-exercise Collagen peptides (CP) supplementation on lean body mass, maximal and explosive, isometric muscle strength as well as fat mass, resting metabolism, health parameters and compared to resistance training alone will be evaluated in a group of untrained overweight male (30-60 yrs) population in a randomized controlled trial (RCT).

Conditions

Body Composition; Lean Body Mass; Muscle Strength; Muscle Power

Outcome Measures

Primary Outcomes (1)

• Lean body mass (kg)

  Lean body mass measured by dual-energy X-ray absorptiometry (DXA)

  Pre (1week prior to intervention) and post (1 week following intervention. i.e 14weeks after inclusion) intervention - about 20 minutes for all dxa-measurements

Secondary Outcomes (9)

• Fat mass (kg)

  Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 20 minutes for all dxa-measurements

• Resting energy expenditure (kcal pr. day)

  Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - 15-25 minutes in total

• 1 Repetition maximum strength (kg)

  Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 25 minutes for all 1RM measurements

• Maximal isometric knee extensor force (Nm)

  Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 25 minutes for all isokinetic dynamometer measurements

• Rate of force development (Nm/sec)

  Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 25 minutes for all isokinetic dynamometer measurements

Other Outcomes (14)

• Dietary intake

  Pre (1 week prior to intervention) and during the intervention period (week 10 if the intervention) - N/A

• Systolic and diastolic of the ankle and brachii (mm/Hg)

  Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 3 minutes

• Questionnaires about health status (36-Item Short Form Survey (SF-36))

  Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 5 minutes

Study Arms (2)

Collagen peptide group

EXPERIMENTAL

This group will consume 1 serving of Collagen peptides, which is produced and marketed ® by GELITA AG, Germany under the brand name BODYBALANC each day.

Dietary Supplement: Effect of collagen peptides, in combination with resistance training, on body composition and muscle strength compared to placebo in untrained men

Placebo group

PLACEBO COMPARATOR

This group will consume 1 serving of silicon dioxide (Sipernat 350, Evonik, Germany) each day. The product is absorbed in negligible amounts by the intestine and does therefore induce minor metabolic effects.

Dietary Supplement: Placebo Control intervention: Effect of resistance training in combination with placebo (silicon dioxide), on body composition and muscle strength in untrained men

Interventions

Effect of collagen peptides, in combination with resistance training, on body composition and muscle strength compared to placebo in untrained men DIETARY_SUPPLEMENT

The effects of collagen peptide consumption in combination with resistance training will be tested

Collagen peptide group

Placebo Control intervention: Effect of resistance training in combination with placebo (silicon dioxide), on body composition and muscle strength in untrained men DIETARY_SUPPLEMENT

The effects of placebo consumption in combination with resistance training will be tested

Placebo group

Eligibility Criteria

• Age: 30 Years - 60 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male, between 30 and 60 years of age
• Fat mass \>25 % as measured by bioelectrical impedance analysis
• Stable weight (±5 %) and eating behaviour within the last 3 months.
• Signed informed consent

You may not qualify if:

• Regular physical activity \>60 min / week
• Stabile or progressive diseases/conditions (including medication) contraindicating or disabling participation in intensive exercise training and/or with potential to affect training adaptation beyond normal variation. For example:
• Contraindications against physical stress corresponding guidelines of American College of Sports Medicine (ACSM)
• Subjective symptoms during exercise (e.g., unusual physical exhaustion, dyspnoea, nausea)
• Moderate to severe mobility limitation (i.e., due to rheumatic disease)
• Diagnosis of cancer within the last 5 years
• Diabetes mellitus I and II uncontrolled arterial hypertension (systolic blood pressure \>155 for mmHg and/or diastolic blood pressure \>94 mm Hg; mild hypertension under resting condition will be allowed but such participants will be recommended to consult their general practitioner).
• Conditions contraindicating the supplementation protocol.
• Contraindications against nutritional or ergogenic supplements
• Allergy/aversion against animal protein
• Liver or kidney diseases with a non-permission to ingest certain concentrations of protein.

Sponsors & Collaborators

• University of Southern Denmark: lead
• CRI Collagen Research Institute GmbH: collaborator

Study Sites (1)

The Department of Sports Science and Clinical Biomechanics at University of Southern Denmark

Odense, 5000, Denmark

Location

MeSH Terms

Interventions

Resistance Training; Silicon Dioxide; Muscle Strength

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Minerals; Inorganic Chemicals; Oxides; Oxygen Compounds; Silicon Compounds; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Participants will be allocated to either placebo or collagen peptide supplementation in a double blinded randomized design. Only following completion of all participants will the blinding be removed
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: A double blinded randomized controlled trial

Study Record Dates

• First Submitted: September 13, 2023
• First Posted: September 29, 2023
• Study Start: September 15, 2023
• Primary Completion: November 23, 2024
• Study Completion: November 23, 2024
• Last Updated: May 5, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)