NCT07484646

Brief Summary

The purpose of this randomized controlled trial is to determine the effects of Electrical Muscle Stimulation (EMS) combined with resistance training on muscle mass, muscular strength, body composition, and power in trained weightlifters. Participants will be randomly allocated into two groups: one receiving resistance training alone and the other receiving EMS combined with resistance training. The intervention will be conducted for eight weeks, and outcome measures will be assessed at baseline, mid-intervention (4 weeks), and post-intervention (8 weeks). The findings of this study may provide evidence regarding the additional benefits of EMS when combined with conventional resistance training programs in enhancing muscular performance among trained athletes.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
34

participants targeted

Target at P25-P50 for not_applicable

Timeline
3mo left

Started Dec 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress63%
Dec 2025Sep 2026

Study Start

First participant enrolled

December 1, 2025

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

February 23, 2026

Completed
25 days until next milestone

First Posted

Study publicly available on registry

March 20, 2026

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2026

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2026

Last Updated

March 20, 2026

Status Verified

March 1, 2026

Enrollment Period

8 months

First QC Date

February 23, 2026

Last Update Submit

March 16, 2026

Conditions

Keywords

Muscle MassMuscle StrengthBody CompositionResistance TrainingElectrical Muscle Stimulation

Outcome Measures

Primary Outcomes (8)

  • Mid Upper Arm Circumference

    This measurement helps assess muscle size and mass in the upper arm. It is a simple, non-invasive way to estimate changes in muscle growth

    Baseline, Week 4, Week 8

  • Thigh Circumference

    This measures the circumference of the thigh, another area where muscle growth can be tracked. It gives insights into lower-body muscle mass

    Baseline, Week 4, Week 8

  • Skinfold Thickness

    This refers to the measurement of skinfolds at specific body sites (such as triceps, abdomen, and thigh) using calipers. It provides an estimate of subcutaneous fat and indirectly reflects muscle mass as well

    Baseline, Week 4, Week 8

  • 30s Sit-to-Stand Test

    This test measures functional lower-body strength by counting how many times a person can rise from a chair in 30 seconds. It assesses leg strength and endurance

    Baseline, Week 4, Week 8

  • Arm Curl Test

    This evaluates upper-body strength by counting how many bicep curls a person can perform in 30 seconds using a set weight. It focuses on arm muscle endurance and strength

    Baseline, 4 Week, 8 Week

  • 1RM Estimation (One Repetition Maximum)

    This measures the maximum amount of weight a person can lift in 1 repetition for a given exercise (like squats). Estimating the 1RM helps evaluate maximal strength

    Baseline, 4 Week, 8 Week

  • Vertical Jump Test (Sayers Equation)

    This test measures lower-body power by assessing how high an individual can jump from a standing position. The Sayers equation is used to calculate power output from the vertical jump height

    Baseline, 4 Week, 8 Week

  • Standing Long Jump

    This test assesses lower-body power and strength by measuring how far an individual can jump forward from a standing start

    Baseline, 4 Week, 8 Week

Study Arms (2)

EMS + Resistance Training

EXPERIMENTAL

Participants will receive supervised resistance training combined with Electrical Muscle Stimulation (EMS). EMS Parameters: Frequency: 85 Hz Pulse Duration: 400 µs Duty Cycle: 10 seconds ON / 50 seconds OFF Duration: 3 sessions per week for 8 weeks EMS will be applied over major muscle groups during compound resistance exercises.

Other: EMS + Resistance Training

Resistance Training Only

ACTIVE COMPARATOR

Participants will receive supervised resistance training without EMS application. Training Frequency: 3 sessions per week Duration: 8 weeks

Other: Resistance Training Only

Interventions

This group will combine the benefits of both EMS and Resistance Training to maximize muscle mass, strength, and body composition improvements using both EMS and RT (18). EMS will be applied to muscles using a frequency-specific protocol. EMS treatment according to the parameters defined as frequency (85 Hz), pulse duration (400 1s), and the duty cycle (10s on: 50s off). Exercises: A complementary schedule of EMS and resistance exercises. Frequency: 3 times per week (Tuesday, Thursday, Saturday) for 8 weeks.

EMS + Resistance Training

This protocol will emphasize muscle strengthening through resistance training to improve strength and muscle mass through traditional resistance training methods (7). Exercises: A selection of exercises focusing on muscle mass and strength. Compound exercises (such as squats, deadlifts, bench press) and isolation exercises (such as bicep curls, triceps extensions) Frequency: 3 times per week (Monday, Wednesday, Friday) for 8 weeks.

Resistance Training Only

Eligibility Criteria

Age18 Years - 40 Years
Sexmale(Gender-based eligibility)
Gender Eligibility DetailsMales subjects will be included
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Male participants aged 18-40 years
  • Resistance training ≥3 times/week for at least 1 year
  • Active participation in weightlifting, bodybuilding, or strength athletics
  • Medically cleared for physical activity

You may not qualify if:

  • Neuromuscular disorders
  • Cardiac pacemaker or implantable electronic device
  • Recent musculoskeletal injury (within the last 6 months)
  • Skin sensitivity or allergy to EMS electrodes

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Punjab Sports Board

Lahore, Punjab Province, 547000, Pakistan

RECRUITING

Related Publications (6)

  • Amarante do Nascimento M, Nunes JP, Pina FLC, Ribeiro AS, Carneiro NH, Venturini D, Barbosa DS, Mayhew JL, Cyrino ES. Comparison of 2 Weekly Frequencies of Resistance Training on Muscular Strength, Body Composition, and Metabolic Biomarkers in Resistance-Trained Older Women: Effects of Detraining and Retraining. J Strength Cond Res. 2022 May 1;36(5):1437-1444. doi: 10.1519/JSC.0000000000003799. Epub 2020 Aug 27.

    PMID: 32868680BACKGROUND
  • Arazi H, Asadi A, Gentil P, Ramirez-Campillo R, Jahangiri P, Ghorbani A, Hackney AC, Zouhal H. Effects of different resistance training frequencies on body composition and muscular performance adaptations in men. PeerJ. 2021 Apr 21;9:e10537. doi: 10.7717/peerj.10537. eCollection 2021.

    PMID: 33976952BACKGROUND
  • Kassiano W, Nunes JP, Costa B, Ribeiro AS, Schoenfeld BJ, Cyrino ES. Does Varying Resistance Exercises Promote Superior Muscle Hypertrophy and Strength Gains? A Systematic Review. J Strength Cond Res. 2022 Jun 1;36(6):1753-1762. doi: 10.1519/JSC.0000000000004258. Epub 2022 Apr 1.

    PMID: 35438660BACKGROUND
  • Mcleod JC, Currier BS, Lowisz CV, Phillips SM. The influence of resistance exercise training prescription variables on skeletal muscle mass, strength, and physical function in healthy adults: An umbrella review. J Sport Health Sci. 2024 Jan;13(1):47-60. doi: 10.1016/j.jshs.2023.06.005. Epub 2023 Jun 28.

    PMID: 37385345BACKGROUND
  • Grgic J, Schoenfeld BJ, Davies TB, Lazinica B, Krieger JW, Pedisic Z. Effect of Resistance Training Frequency on Gains in Muscular Strength: A Systematic Review and Meta-Analysis. Sports Med. 2018 May;48(5):1207-1220. doi: 10.1007/s40279-018-0872-x.

    PMID: 29470825BACKGROUND
  • Kaabi S, Mabrouk RH, Passelergue P. Weightlifting Is Better Than Plyometric Training to Improve Strength, Counter Movement Jump, and Change of Direction Skills in Tunisian Elite Male Junior Table Tennis Players. J Strength Cond Res. 2022 Oct 1;36(10):2912-2919. doi: 10.1519/JSC.0000000000003972. Epub 2021 Feb 24.

    PMID: 33629971BACKGROUND

MeSH Terms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Aifa Zeenat, MS*

    Riphah International University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Danish Hassan, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 23, 2026

First Posted

March 20, 2026

Study Start

December 1, 2025

Primary Completion (Estimated)

August 1, 2026

Study Completion (Estimated)

September 1, 2026

Last Updated

March 20, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share

Locations