NCT06043492

Brief Summary

Aerobic capacity is critical for many athletes, especially for endurance athletes. Althgough several training methods are implemented by coaches to improve endurance performance, recovery following acute endurance training is not adequately studied. However, such information is crucial for coaches to effectively design the most favorable training program, to avoid muscle injuries and overtraining, and ultimately to improve performance of their athletes. This study aims to examine the acute effect of different continuous and HIIT training protocols on indices of metabolism, EIMD, neuromuscular fatigue and performance in middle- and long-distance runners.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Sep 2023

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 17, 2023

Completed
4 days until next milestone

First Posted

Study publicly available on registry

September 21, 2023

Completed
9 days until next milestone

Study Start

First participant enrolled

September 30, 2023

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 15, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 15, 2023

Completed
Last Updated

January 23, 2024

Status Verified

January 1, 2024

Enrollment Period

3 months

First QC Date

September 17, 2023

Last Update Submit

January 21, 2024

Conditions

Outcome Measures

Primary Outcomes (11)

  • Changes in Creatine kinase (CK)

    CK will be measured in plasma using a Clinical Chemistry Analyzer with commercially available kits.

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Changes in DOMS

    DOMS of knee extensors and knee flexors of both lower extremities will be measured during palpation of the muscle belly and the distal region after performing three repetitions of a full squat.

    Baseline (pre), post-, 24 hours post-, 48 hours post-, 72 hours post-trial

  • Changes in blood lactate

    Lactate will be measured in capillary blood with a hand-portable analyzer.

    Baseline (pre), 4 minutes post-trial

  • Changes in squat jump height

    Squat jump height will be measured with a photocells system.

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Changes in mean jump height during a 30 sec Bosco test

    Mean jump height will be measured with a photocells system.

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Changes in peak power during a 30 sec Bosco test

    Peak power will be measured with a photocells system.

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Changes in mean power during a 30 sec Bosco test

    Mean power will be measured with a photocells system.

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Changes in fatigue rate during a 30 sec Bosco test

    Fatigue rate will be estimated through the persent drop in mean jump height between the first 5 jumps and the last 5 jumps.

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Changes in maximal voluntary isometric contraction (MVIC)

    MVIC of the knee extensors and knee flexors will be measured on an isokinetic dynamometer.

    Baseline (pre), 1 hour post-, 2 hours post-, 3 hours post-, 24 hours post-, 48 hours post-, 72 hours post-trial

  • Changes in peak concentric torque

    Concentric torque of the knee extensors and knee flexors will be measured on an isokinetic dynamometer.

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Changes in peak eccentric torque

    Eccentric torque of the knee extensors and knee flexors will be measured on an isokinetic dynamometer.

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

Secondary Outcomes (7)

  • Body weight

    Baseline

  • Body height

    Baseline

  • Body mass index (BMI)

    Baseline

  • Body fat

    Baseline

  • Lean body mass

    Baseline

  • +2 more secondary outcomes

Study Arms (3)

High Intensity Interval Training

EXPERIMENTAL

The participants will perform an acute bout of high intensity interval training

Other: High Intensity Interval Training

Coninuous Running

EXPERIMENTAL

The participants will perform an acute bout of continuous running

Other: Coninuous Running

Control Trial

OTHER

The participants will not perform any endurance exercise protocol

Other: Control Trial

Interventions

10 x 2 min running at vVO2max, interspersed by 2 min recovery at 40% VO2max

High Intensity Interval Training

40 min continuous running at lactate threshold

Coninuous Running

The participants will perform only the baseline and post acute-training evaluations, without performing exercise

Control Trial

Eligibility Criteria

Age18 Years - 40 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Middle- and long-distance runners
  • Absence of musculoskeletal injuries (≥ 6 months)
  • No use of drugs or ergogenic supplements (≥ 1 month)
  • Absense from eccentric exercise (≥ 3 days)
  • No alcohol or ergogenic drinks consumption before each training protocol

You may not qualify if:

  • Musculoskeletal injury (\< 6 months)
  • Use of drugs or ergogenic supplements (\< 1 month)
  • Participation in eccentric exercise (\< 3 days)
  • Alcohol or ergogenic drinks consumption before the training protocol

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Physical Education and Sport Science, Uninersity of Thessaly

Trikala, Thessaly, 42100, Greece

Location

Related Publications (6)

  • Barnes KR, Kilding AE. Strategies to improve running economy. Sports Med. 2015 Jan;45(1):37-56. doi: 10.1007/s40279-014-0246-y.

    PMID: 25164465BACKGROUND
  • Brandao LHA, Chagas TPN, Vasconcelos ABS, de Oliveira VC, Fortes LS, de Almeida MB, Mendes Netto RS, Del-Vecchio FB, Neto EP, Chaves LMS, Jimenez-Pavon D, Da Silva-Grigoletto ME. Physiological and Performance Impacts After Field Supramaximal High-Intensity Interval Training With Different Work-Recovery Duration. Front Physiol. 2020 Oct 8;11:1075. doi: 10.3389/fphys.2020.01075. eCollection 2020.

    PMID: 33162893BACKGROUND
  • Cipryan L. IL-6, Antioxidant Capacity and Muscle Damage Markers Following High-Intensity Interval Training Protocols. J Hum Kinet. 2017 Mar 15;56:139-148. doi: 10.1515/hukin-2017-0031. eCollection 2017 Feb.

    PMID: 28469752BACKGROUND
  • Esfarjani F, Laursen PB. Manipulating high-intensity interval training: effects on VO2max, the lactate threshold and 3000 m running performance in moderately trained males. J Sci Med Sport. 2007 Feb;10(1):27-35. doi: 10.1016/j.jsams.2006.05.014. Epub 2006 Jul 28.

    PMID: 16876479BACKGROUND
  • Hottenrott K, Ludyga S, Schulze S. Effects of high intensity training and continuous endurance training on aerobic capacity and body composition in recreationally active runners. J Sports Sci Med. 2012 Sep 1;11(3):483-8. eCollection 2012.

    PMID: 24149357BACKGROUND
  • Martinez-Ferran M, Cuadrado-Penafiel V, Sanchez-Andreo JM, Villar-Lucas M, Castellanos-Montealegre M, Rubio-Martin A, Romero-Morales C, Casla-Barrio S, Pareja-Galeano H. Effects of Acute Vitamin C plus Vitamin E Supplementation on Exercise-Induced Muscle Damage in Runners: A Double-Blind Randomized Controlled Trial. Nutrients. 2022 Nov 3;14(21):4635. doi: 10.3390/nu14214635.

    PMID: 36364898BACKGROUND

MeSH Terms

Interventions

High-Intensity Interval Training

Intervention Hierarchy (Ancestors)

Physical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Chariklia K Deli, PhD

    University of Thessaly

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SCREENING
Intervention Model
CROSSOVER
Model Details: The same participants will participate in three different conditions
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

September 17, 2023

First Posted

September 21, 2023

Study Start

September 30, 2023

Primary Completion

December 15, 2023

Study Completion

December 15, 2023

Last Updated

January 23, 2024

Record last verified: 2024-01

Data Sharing

IPD Sharing
Will not share

Locations