NCT04847427

Brief Summary

Muscle power is one of the most important parameters in almost every athletic action, expressing the ability of the human muscle to produce great amounts of force with the greatest possible speed. For enhancing their muscle power, athletes comprise several resistance training programs as part of their training. However, muscle power training comprises of eccentric muscle actions, which, especially when unaccustomed, can lead to exercise-induced muscle damage and deterioration of muscle performance. Nevertheless, despite the fact that muscle power training comprises eccentric muscle actions, and consequently can lead to muscle injury and muscle performance reduction during the following days, the recovery kinetics after acute muscle power training have not been adequately studied. However, information regarding the recovery of the muscles after a power training protocol, is critical for the correct design of a training microcycle, and the reduction of injury risk. The aim of the present study is to investigate the muscle injury provoked after acute muscle power training using three different power training exercise protocols. Additionally, the effect of these protocols on muscle performance and neuromuscular fatigue indices will be examined.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Apr 2021

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 10, 2021

Completed
2 months until next milestone

First Posted

Study publicly available on registry

April 19, 2021

Completed
1 day until next milestone

Study Start

First participant enrolled

April 20, 2021

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 30, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2021

Completed
Last Updated

February 18, 2022

Status Verified

February 1, 2022

Enrollment Period

7 months

First QC Date

February 10, 2021

Last Update Submit

February 17, 2022

Conditions

Outcome Measures

Primary Outcomes (25)

  • Change in CK in blood

    Creatine kinase will be measured in plasma using a biochemical analyzer

    Baseline (pre), 4 minutes post-, 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in delayed onset of muscle soreness (DOMS) in the knee flexors (KF) and extensors (KE) of both limbs

    Participants will perform three repetitions of a full squat movement, and rate their soreness level in knee flexors and extensors on a visual analog scale from 1 to 10 (VAS, with "no pain" at one end and "extremely sore" at the other), using palpation of the belly and the distal region of relaxed knee extensors and flexors.

    Baseline (pre), 4 minutes post-, 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in blood lactate

    Blood lactate will be measured in capillary blood with a hand-portable analyzer

    Baseline (pre), 4 minutes post-trial

  • Change in squat jump height

    Squat jump height will be measured using two force platforms at 1000Hz, with each foot in parallel on the two platforms providing a seperate, yet time-synchronized measurement of the jump height for each leg

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in ground reaction force (GRF) during squat jump test

    GRFwill be measured using two force platforms at 1000Hz, with each foot in parallel on the two platforms providing a seperate, yet time-synchronized measurement of the jump height for each leg

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in peak power during squat jump test

    Peak power will be measured using two force platforms at 1000Hz, with each foot in parallel on the two platforms providing a seperate, yet time-synchronized measurement of the jump height for each leg

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in mean power during squat jump test

    Mean power will be measured using two force platforms at 1000Hz, with each foot in parallel on the two platforms providing a seperate, yet time-synchronized measurement of the jump height for each leg

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in vertical stifness during squat jump test

    Vertical stifness will be measured using two force platforms at 1000Hz, with each foot in parallel on the two platforms providing a seperate, yet time-synchronized measurement of the jump height for each leg

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in peak normalized EMG during the concentric phase of the squat jump test

    Electromyography data will be collected wirelessly at 2000Hz using a Myon MA-320 EMG system (Myon AG, Schwarzenberg, Switzerland) for the vastus lateralis, biceps femoris, gastrocnemius, and gluteus maximum muscles.

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in mean normalized EMG during the concentric phase of the squat jump test

    Electromyography data will be collected wirelessly at 2000Hz using a Myon MA-320 EMG system (Myon AG, Schwarzenberg, Switzerland) for the vastus lateralis, biceps femoris, gastrocnemius, and gluteus maximum muscles.

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in countermovement jump height

    Countermovement jump height will be measured using two force platforms at 1000Hz, with each foot in parallel on the two platforms providing a seperate yet time-synchronized measurement of the jump height for each leg

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in ground reaction force (GRF) during countermovement jump test

    Ground reaction force will be measured using two force platforms at 1000Hz, with each foot in parallel on the two platforms providing a seperate yet time-synchronized measurement of the jump height for each leg

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in peak power during countermovement jump test

    Peak power will be measured using two force platforms at 1000Hz, with each foot in parallel on the two platforms providing a seperate yet time-synchronized measurement of the jump height for each leg

    Baseline (pre), post-, 24h post-, 48h post-, 72h post-trial

  • Change in mean power during countermovement jump test

    Mean power will be measured using two force platforms at 1000Hz, with each foot in parallel on the two platforms providing a seperate yet time-synchronized measurement of the jump height for each leg

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in vertical stifness during countermovement jump test

    Vertical stifness will be measured using two force platforms at 1000Hz, with each foot in parallel on the two platforms providing a seperate yet time-synchronized measurement of the jump height for each leg

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in peak rate of force development during countermovement jump test

    Vertical stifness will be measured using two force platforms at 1000Hz, with each foot in parallel on the two platforms providing a seperate yet time-synchronized measurement of the jump height for each leg

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in peak normalized EMG during the eccentric and concentric phases of the countermovement jump test

    Electromyography data will be collected wirelessly at 2000Hz using a Myon MA-320 EMG system (Myon AG, Schwarzenberg, Switzerland) for the vastus lateralis, biceps femoris, gastrocnemius, and gluteus maximum muscles.

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in mean normalized EMG during the eccentric and concentric phases of the countermovement jump test

    Electromyography data will be collected wirelessly at 2000Hz using a Myon MA-320 EMG system (Myon AG, Schwarzenberg, Switzerland) for the vastus lateralis, biceps femoris, gastrocnemius, and gluteus maximum muscles.

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in concentric peak torque

    Concentric peak torque will be measured on an isokinetic dynamometer

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in eccentric peak torque

    Eccentric peak torque will be measured on an isokinetic dynamometer

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in isometric peak torque

    Eccentric peak torque will be measured on an isokinetic dynamometer

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in maximal voluntary isometric contraction (MVIC) during 10 seconds

    MVIC will be measured on an isokinetic dynamometer

    Baseline (pre), 1 hour post-, 2 hours post-, 3 hours post-, 24 hours post-, 48 hours post-, 72 hours post-trial

  • Change in fatigue rate during maximal voluntary isometric contraction (MVIC)

    Fatigue rate during MVIC will be estimated through the percent drop of peak torque between the first and the last three seconds of a 10-second maximal isometric contaction

    Baseline (pre), 1 hour post-, 2 hours post-, 3 hours post-, 24 hours post-, 48 hours post-, 72 hours post-trial

  • Differences in field activity between the three different power training protocols

    Field activity will be continuously recorded during the power training protocols using global positioning system (GPS) technology

    During each power training protocol

  • Change in heart rate between the three different power training protocols

    Heart rate will be continuously recorded during during the power training protocols using heart rate monitors

    During each power training protocol

Secondary Outcomes (7)

  • Body weight

    Baseline

  • Body height

    Baseline

  • Body mass index (BMI)

    Baseline

  • Maximal oxygen consumption (VO2max)

    Baseline

  • Body fat

    Baseline

  • +2 more secondary outcomes

Study Arms (4)

Core exercises training

EXPERIMENTAL

Participants will perform 4 core exercises

Other: Core exercises training

Structural exercises training

EXPERIMENTAL

Participants will perform 4 structural (Olympic lifting) exercises

Other: Structural exercises training

Accentuated eccentric exercises training

EXPERIMENTAL

Participants will perform 4 exercises with eccentric loading

Other: Accentuated eccentric exercises training

Control trial

EXPERIMENTAL

Participants will perform all the measurements that are comprised in the experimental conditions without performing any exercise protocol

Other: Control trial

Interventions

Participants will perform: 1. Squats, 4 sets of 5 repetitions at 60% 1RM 2. Deadlifts, 4 sets of 5 repetitions at 60% 1RM 3. Lunges, 4 sets of 5 repetitions at 60% 1RM 4. Step ups, 4 sets of 5 repetitions at 60% 1RM

Core exercises training

Participants will perform: 1. Snatch, 4 sets of 5 repetitions at 60% 1RM 2. Hang clean, 4 sets of 5 repetitions at 60% 1RM 3. Push jerk, 4 sets of 5 repetitions at 60% 1RM 4. Split push jerk, 4 sets of 5 repetitions at 60% 1RM

Structural exercises training

Participants will perform: 1. Deadlifts - squat jump, 4 sets of 5 repetitions at 30% body mass (BM) 2. Step down - squat jump, 4 sets of 5 repetitions at 30% BM 3. Step down - lunges, 4 sets of 5 repetitions at 30% BM 4. Bulgarian squat jumps, 4 sets of 5 repetitions at 30% BM

Accentuated eccentric exercises training

Participants will perform all the measurements that are comprised in the experimental conditions without performing any exercise protocol

Control trial

Eligibility Criteria

Age18 Years - 30 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • At least 1 year experience in strength exercises
  • Absense of musculoskeletal injuries (≥ 6 months)
  • Abstence from use of ergogenic supplements or other drugs (≥ 1 month)
  • Abstence from participation at exercise with eccentric component (≥ 3 days)
  • Abstence from alcohol and energy drings consumption before each experimental trial

You may not qualify if:

  • Less than 1 year experience in strength exercises
  • Musculoskeletal injuries (≤ 6 months)
  • Use of ergogenic supplements or other drugs (≤ 1 month)
  • Participation at exercise with eccentric component (≤ 3 days)
  • Alcohol and energy drings consumption before the experimental trials

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Chariklia K. Deli

Trikala, Thessaly, 42100, Greece

Location

Related Publications (7)

  • Clarkson PM, Byrnes WC, McCormick KM, Turcotte LP, White JS. Muscle soreness and serum creatine kinase activity following isometric, eccentric, and concentric exercise. Int J Sports Med. 1986 Jun;7(3):152-5. doi: 10.1055/s-2008-1025753.

    PMID: 3733311BACKGROUND
  • Deli CK, Fatouros IG, Paschalis V, Georgakouli K, Zalavras A, Avloniti A, Koutedakis Y, Jamurtas AZ. A Comparison of Exercise-Induced Muscle Damage Following Maximal Eccentric Contractions in Men and Boys. Pediatr Exerc Sci. 2017 Aug;29(3):316-325. doi: 10.1123/pes.2016-0185. Epub 2017 Feb 6.

    PMID: 28165870BACKGROUND
  • Kyrolainen H, Avela J, McBride JM, Koskinen S, Andersen JL, Sipila S, Takala TE, Komi PV. Effects of power training on muscle structure and neuromuscular performance. Scand J Med Sci Sports. 2005 Feb;15(1):58-64. doi: 10.1111/j.1600-0838.2004.00390.x.

    PMID: 15679573BACKGROUND
  • Ispirlidis I, Fatouros IG, Jamurtas AZ, Nikolaidis MG, Michailidis I, Douroudos I, Margonis K, Chatzinikolaou A, Kalistratos E, Katrabasas I, Alexiou V, Taxildaris K. Time-course of changes in inflammatory and performance responses following a soccer game. Clin J Sport Med. 2008 Sep;18(5):423-31. doi: 10.1097/JSM.0b013e3181818e0b.

    PMID: 18806550BACKGROUND
  • Hughes JD, Massiah RG, Clarke RD. The Potentiating Effect of an Accentuated Eccentric Load on Countermovement Jump Performance. J Strength Cond Res. 2016 Dec;30(12):3450-3455. doi: 10.1519/JSC.0000000000001455.

    PMID: 27100315BACKGROUND
  • Cormie P, McCaulley GO, Triplett NT, McBride JM. Optimal loading for maximal power output during lower-body resistance exercises. Med Sci Sports Exerc. 2007 Feb;39(2):340-9. doi: 10.1249/01.mss.0000246993.71599.bf.

    PMID: 17277599BACKGROUND
  • Walker S, Blazevich AJ, Haff GG, Tufano JJ, Newton RU, Hakkinen K. Greater Strength Gains after Training with Accentuated Eccentric than Traditional Isoinertial Loads in Already Strength-Trained Men. Front Physiol. 2016 Apr 27;7:149. doi: 10.3389/fphys.2016.00149. eCollection 2016.

    PMID: 27199764BACKGROUND

Study Officials

  • Chariklia K Deli, PhD

    Department of Physical Education and Sport Science, University of Thessaly

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SCREENING
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

February 10, 2021

First Posted

April 19, 2021

Study Start

April 20, 2021

Primary Completion

November 30, 2021

Study Completion

November 30, 2021

Last Updated

February 18, 2022

Record last verified: 2022-02

Data Sharing

IPD Sharing
Will not share

Locations