Effect of High Intensity Interval Training in Patients With Multiple Sclerosis

NCT05954195 | Unknown

• 1 other identifier: HIIT in MS patients
• Study Type: interventional
• Target: 86
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, we are aiming to systematically review the literature on the effect of HIIT on MS patients as improving physical performance, cognitive function, aerobic fitness and muscle strength. This could help guide the development of standardized clinical guidelines and direct clinical decision making by the physical therapists whether to implement this type of exercises or not.

Conditions

Multiple Sclerosis

Keywords

Multiple sclerosis AND high intensity interval training

Outcome Measures

Primary Outcomes (1)

• cognitive function

  serum levels of serotonin and brain derived necrotic factor (BDNF)

  8-12 weeks or less

Secondary Outcomes (1)

• mental processing speed

  8-12 weeks or less

Study Arms (2)

HIIT group

ACTIVE COMPARATOR

The group who received high intensity interval training

Other: high intensity interval training

control/comparator group

PLACEBO COMPARATOR

control group that might be placebo group, standard care group or no intervention group

Other: high intensity interval training

Interventions

high intensity interval training OTHER

high intensity interval training through ergometer, with whole treatment session between 20 - 30 minutes divided into 3 parts, the 1st is warming up (40% of HRmax intensity for 2/3/5 minutes then the active training part (intervals of 85-90% of HRmax for 1 minute then rest period of 1 minute of 40 % of HRmax and so on for nearly 20 minutes ) then the last part is cooling down (30 % of HRmax for 3/5 minutes).

Also known as: progressive aerobic training, sprinting interval exercise

HIIT group; control/comparator group

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Studies: English full texts of RCTs only, Participants: multiple sclerosis patients with age from (20-50) years old irrespectively of sex, subtype of MS, race, diagnostic criteria, community or onset of the disease, Intervention: HIIT, any comparator.

You may not qualify if:

• Studies other than English full text RCTs, non adults younger than 20 years and older than 50 years, populations other than multiple sclerosis.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Azzarqa

Damietta, 34724, Egypt

RECRUITING

Related Publications (3)

• Zimmer P, Bloch W, Schenk A, Oberste M, Riedel S, Kool J, Langdon D, Dalgas U, Kesselring J, Bansi J. High-intensity interval exercise improves cognitive performance and reduces matrix metalloproteinases-2 serum levels in persons with multiple sclerosis: A randomized controlled trial. Mult Scler. 2018 Oct;24(12):1635-1644. doi: 10.1177/1352458517728342. Epub 2017 Aug 21.

  PMID: 28825348 RESULT

• Langeskov-Christensen M, Grondahl Hvid L, Nygaard MKE, Ringgaard S, Jensen HB, Nielsen HH, Petersen T, Stenager E, Eskildsen SF, Dalgas U. Efficacy of High-Intensity Aerobic Exercise on Brain MRI Measures in Multiple Sclerosis. Neurology. 2021 Jan 12;96(2):e203-e213. doi: 10.1212/WNL.0000000000011241. Epub 2020 Dec 1.

  PMID: 33262230 RESULT

• Spaas J, Goulding RP, Keytsman C, Fonteyn L, van Horssen J, Jaspers RT, Eijnde BO, Wust RCI. Altered muscle oxidative phenotype impairs exercise tolerance but does not improve after exercise training in multiple sclerosis. J Cachexia Sarcopenia Muscle. 2022 Oct;13(5):2537-2550. doi: 10.1002/jcsm.13050. Epub 2022 Aug 4.

  PMID: 35929063 RESULT

MeSH Terms

Conditions

Multiple Sclerosis

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Abeer Abobakr Dr Alwishy, Professor

  Physical therapy for neuromuscular disorders and its surgeries, Cairo university

  STUDY CHAIR

• Neveen Mohy-Eldin shalaby, professor

  Faculty of medicine, Alqasr elainy, Cairo university

  STUDY CHAIR

• Hossam M. Elsaid, lecturer

  Faculty of physical therapy of neuromuscloskeletal disorders and its surgeries, Cairo universities

  STUDY CHAIR

Central Study Contacts

Fatma Khaled M. Abdelaziz, master

CONTACT

+2001006196295; fabdelaziz@horus.edu.eg

Hossam M. Elsaid, lecturer

CONTACT

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: the studies mask the participants and they randomly divided into 2 groups then the care provider is masked too not to choose specific participant for specific intervention then the outcome assessor is masked to document the outcomes with fair then the investigator is masked too to document results honestly without being motivated towards the intervention.
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Fatma Khaled Mohamed Abdelaziz

Model Details: high intensity interval training starting by warm up period of 40 % from the HRmax then the interval exercise period of 85-90 % from HRmax ending by cool down period from 30 % of HRmax

Study Record Dates

• First Submitted: July 12, 2023
• First Posted: July 20, 2023
• Study Start: July 20, 2023
• Primary Completion: November 30, 2023
• Study Completion: December 18, 2023
• Last Updated: July 20, 2023

Record last verified: 2023-07

Locations

EG (1)