Effect of Dual Task Exercise on Cognitive and Physical Function in the Elderly With Mild Cognitive Impairment

NCT05855785 | Completed

• 1 other identifier: 20-2020-38
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the effect of the dual task exercise program on cognitive and physical function in the elderly with mild cognitive impairment.

Conditions

Cognitive Dysfunction; Mild Cognitive Impairment

Outcome Measures

Primary Outcomes (4)

• Dual task cost in Timed up and go (TUG)

  Participants completed both single-task (ST) and dual-task (DT) tests at baseline and post-intervention. For a ST condition, participants performed motor task only such as Timed up and go (TUG). TUG measured the time of taking to rise from a chair, walking three meters, turning around 180 degrees, walking back to the chair, and sitting down while turning 180 degrees. For a DT condition, participants performed TUG while performing serial 3 simultaneously. Serial 3 is descending subtraction task, where the patient counts down from one hundred by threes. In the DT condition, participants were given no instruction regarding the prioritization of one task over the other. We calculated TUG duration in both conditions. Dual task cost(DTC) were calculated as a percentage as follows: (%DTC) = \[dual task duration or speed - single task duration or speed\] / \[single task duration or speed\] \* 100%. The lower DTC indicates efficiency in cognitive-motor interplay and good dual task ability.

  Baseline

• Dual task cost in 10-meter walking test

  Participants completed both single-task (ST) and dual-task (DT) tests at baseline and post-intervention. For a ST condition, participants performed motor task only such as 10-meter walking test (10MWT). 10MWT is a performance measure used to assess walking speed over a short distance. For a DT condition, participants performed 10MWT while performing serial 3 simultaneously. Serial 3 is descending subtraction task, where the patient counts down from one hundred by threes. In the DT condition, participants were given no instruction regarding the prioritization of one task over the other. We calculated 10MWT gait speed in both conditions. Dual task cost(DTC) were calculated as a percentage as follows: (%DTC) = \[dual task duration or speed - single task duration or speed\] / \[single task duration or speed\] \* 100%. The lower DTC indicates efficiency in cognitive-motor interplay and good dual task ability.

  Baseline

• Dual task cost in Timed up and go (TUG)

  Participants completed both single-task (ST) and dual-task (DT) tests at baseline and post-intervention. For a ST condition, participants performed motor task only such as Timed up and go (TUG). TUG measured the time of taking to rise from a chair, walking three meters, turning around 180 degrees, walking back to the chair, and sitting down while turning 180 degrees. For a DT condition, participants performed TUG while performing serial 3 simultaneously. Serial 3 is descending subtraction task, where the patient counts down from one hundred by threes. In the DT condition, participants were given no instruction regarding the prioritization of one task over the other. We calculated TUG duration in both conditions. Dual task cost(DTC) were calculated as a percentage as follows: (%DTC) = \[dual task duration or speed - single task duration or speed\] / \[single task duration or speed\] \* 100%. The lower DTC indicates efficiency in cognitive-motor interplay and good dual task ability.

  immediately after the 8-week intervention

• Dual task cost in 10-meter walking test

  Participants completed both single-task (ST) and dual-task (DT) tests at baseline and post-intervention. For a ST condition, participants performed motor task only such as 10-meter walking test (10MWT). 10MWT is a performance measure used to assess walking speed over a short distance. For a DT condition, participants performed 10MWT while performing serial 3 simultaneously. Serial 3 is descending subtraction task, where the patient counts down from one hundred by threes. In the DT condition, participants were given no instruction regarding the prioritization of one task over the other. We calculated 10MWT gait speed in both conditions. Dual task cost(DTC) were calculated as a percentage as follows: (%DTC) = \[dual task duration or speed - single task duration or speed\] / \[single task duration or speed\] \* 100%. The lower DTC indicates efficiency in cognitive-motor interplay and good dual task ability.

  immediately after the 8-week intervention

Secondary Outcomes (30)

• Korean Montreal Cognitive Assessment (MoCA-K)

  Baseline

• Korean Montreal Cognitive Assessment (MoCA-K)

  immediately after the 8-week intervention

• Korean Mini Mental Status Examination (K-MMSE)

  Baseline

• Korean Mini Mental Status Examination (K-MMSE)

  immediately after the 8-week intervention

• Computerized cognitive test(digit span test, visual learning test, verbal learning test, the Stroop Color and Word test, Boston naming test, trail making test, and verbal fluency test)

  Baseline

Study Arms (2)

The exercise group

EXPERIMENTAL

The exercise group underwent 8-week, 3 times a week, 60-minute group exercise sessions, which were comprised of moderate-to-high intensity exercise and simultaneous cognitive tasks. The exercise group also performed moderate-intensity home aerobic exercises for at least 60 minutes per week.

Behavioral: dual task exercise

The control group

OTHER

The control group performed 60-minute light intensity home exercise, 4 times a week for 8 weeks.

Behavioral: home exercise

Interventions

dual task exercise BEHAVIORAL

8-week, 3 times a week, 60-minute group exercise sessions, which were comprised of moderate-to-high intensity exercise and simultaneous cognitive tasks

The exercise group

home exercise BEHAVIORAL

60-minute light intensity home exercise, 4 times a week for 8 weeks

The control group

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• a score on the Korean Montreal Cognitive Assessment (MoCA-K) of 25 points or below
• aged 65 or more
• no physical or medical problem which impairs moderate to vigorous physical activity

You may not qualify if:

• uncontrolled or unstable cardiovascular disease
• malignancy affecting general condition
• musculoskeletal problems affecting motor performance
• speech and hearing impairment
• other organic brain diseases

Sponsors & Collaborators

• Seoul National University Boramae Hospital: lead
• National Rehabilitation Center, Ministry of Health and Welfare, Korea: collaborator

Study Sites (1)

Seoul National University Boramae Medical Center

Seoul, 07061, South Korea

Location

Related Publications (1)

• Plummer P, Eskes G. Measuring treatment effects on dual-task performance: a framework for research and clinical practice. Front Hum Neurosci. 2015 Apr 28;9:225. doi: 10.3389/fnhum.2015.00225. eCollection 2015.

  PMID: 25972801 BACKGROUND

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Se Hee Jung, MD, PhD

  Department of Rehabilitation Medicine, Seoul National University Boramae Medical Center

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 30, 2023
• First Posted: May 11, 2023
• Study Start: May 1, 2020
• Primary Completion: September 30, 2020
• Study Completion: April 8, 2021
• Last Updated: May 11, 2023

Record last verified: 2023-05

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)