The Effectiveness of Dual Task Training in Elderly With Cognitive Decline

NCT04689776 | Unknown

• 1 other identifier: 201912EM016
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Cognitive decline is the impairment of memory, execution, or language. Early detection of the individuals who manifest cognitive decline and provide appropriate interventions may help reduce the burden of their caregivers and the medical expenses of the health-care system. Many studies have found that dual-task training combining cognitive training and exercise can improve cognitive function in older adults. However, it is yet not clear the appropriate frequency of the effective dual-task training for elderly with cognitive decline. Thus, this study aims to compare the intervention effects of high frequency sequential and low frequency dual-task training for elderly with cognitive decline.

Conditions

Mild Cognitive Impairment

Keywords

Mild Cognitive Impairment; Cognitive Training; Exercise

Outcome Measures

Primary Outcomes (8)

• Change scores of the Montreal Cognitive Assessment (MoCA)

  The Montreal Cognitive Assessment (MoCA) was designed as a rapid screening instrument for mild cognitive dysfunction. It assesses different cognitive domains: attention and concentration, executive functions, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation. Time to administer the MoCA is approximately 10 minutes. The total possible score is 30 points; a score of 26 or above is considered normal.

  baseline, posttest (around 12 weeks after baseline)

• Change scores of Mini-Mental State Exam (MMSE)

  The Mini-Mental State Examination (MMSE) is the most commonly administered psychometric screening assessment of cognitive functioning. The MMSE is used to screen patients for cognitive impairment, track changes in cognitive functioning over time, and often to assess the effects of therapeutic agents on cognitive function. The total score of MMSE ranged from 0 to 30. Higher values represent a better cognitive functioning.

  baseline, posttest (around 12 weeks after baseline)

• Change scores of the Stroop test

  The Stroop test will be used to assess the processing speed, inhibition, set-shifting, and selective attention abilities. The participants will be tested under 2 conditions: congruent and incongruent conditions. In the congruent condition, the color ink of a word is consistent with the written color name; while the color ink differs from the written color name under the incongruent condition.

  baseline, posttest (around 12 weeks after baseline)

• Change scores of the Timed up and go (TUG) test

  The TUG test will be used to assess the mobility and dynamic balance ability. The participants will be required to stand up from a chair, walk 3 meters, turn around, then walk back to the chair, and sit down. The time to complete the TUG test has been shown to be a good indicator to detect potential fallers and frail elderly (Podsiadlo \& Richardson, 1991). The test-retest reliability of TUG on individuals with cognitive impairment was excellent.

  baseline, posttest (around 12 weeks after baseline)

• Change scores of the Dual-task test

  The dual-task tests will be assessed to determine the ability for an individual to perform 2 tasks simultaneously. The investigators will assess the dual-task performance during walking and performing box and block test. The results of the dual-task tests will provide information regarding to whether the 2 tasks compete for the same class of neural resources or one of the tasks can be carried out automatically

  baseline, posttest (around 12 weeks after baseline)

• Change scores of the Wechsler Adult Intelligence Scale (WAIS)

  Subtests of the Wechsler Adult Intelligence Scale (WAIS) will be used to measure the cognitive functions of an individual. The WAIS have high reliability and validity, and is often used to differentiate individuals with cognitive deficits and those with intact cognitive functions. In addition, WAIS could be used to assess cognitive improvements after an intervention or treatment.

  baseline, posttest (around 12 weeks after baseline)

• Change scores of the Lawton Instrumental Activities of Daily Living Scale (IADL)

  Assess activities of daily living. There are 8 domains of function measured with the Lawton IADL scale, including ability to use phone,shopping, food preparation, housekeeping, laundering, mode of transportation, responsibility for own medications,and ability to handle finances. A summary score ranges from 0 (low function, dependent) to 8 (high function, independent). For each category, circle the item description that most closely resembles the client's highest functional level (either 0 or 1).

  baseline, posttest (around 12 weeks after baseline)

• Change scores of the Wechsler Memory Scale (WMS)

  The Wechsler Memory Scale (WMS) was designed to measure different memory functions. The subtests, including Word Lists, and Spatial Span will be used to assess the immediate, delayed, and working memory. Time to administer the WMS subtests is approximately 45 minutes. The total scores range from 0-48 for the immdiate memory, and 0-24 for the delayed memory. Higher values represent a better cognitive functioning.

  baseline, posttest (around 12 weeks after baseline)

Secondary Outcomes (3)

• Change scores of the Community Integration Questionnaire (CIQ)

  baseline, posttest (around 12 weeks after baseline)

• Change scores of Geriatric Depression Scale (GDS)

  baseline, posttest (around 12 weeks after baseline)

• Change scores of the Everyday Cognition scales (ECog)-12 items

  baseline, posttest (around 12 weeks after baseline)

Study Arms (2)

High Frequency Dual-Task Training (HF)

EXPERIMENTAL

The participants of HF will receive a total of 36 training sessions, and each session will contain 90-120 minutes of training.

Behavioral: Dual-Task Training

Low Frequency Dual-Task Training (LF)

EXPERIMENTAL

The participants of LF will receive a total of 12 training sessions, and each session will contain 90-120 minutes of training.

Behavioral: Dual-Task Training

Interventions

Dual-Task Training BEHAVIORAL

The programs are based on dual-task trainings which contain cognitive training and exercise simultaneously. For physical exercise, we will design the programs that involve balance or strength training components in the aerobic exercises. In terms of cognitive training, we will design self-made teaching aids and board games to train different domains of cognitive functions. We plan to assess the participants before and after the intervention programs. We expect that elders receiving dual-task training will improve on outcome measures, and the group with more frequency will have better performance. The results of the study will provide evidence of interventions for elderly with cognitive decline, thereby reducing the burden on their caregivers and the cost of medical resource.

High Frequency Dual-Task Training (HF); Low Frequency Dual-Task Training (LF)

Eligibility Criteria

• Age: 55 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• able to follow instruction (MMSE\>= 20)
• self- or informant-reported memory or cognitive complaint.

You may not qualify if:

• recent myocardial infarction,heart failure,recent heart surgery,
• severe asthma, concomitant with other neurological disorders, or joint deformity that might prevents them performing exercise or cognitive training.

Sponsors & Collaborators

• Chang Gung Memorial Hospital: lead

Study Sites (1)

Chang Gung Memorial Hospital

Taoyuan District, 333, Taiwan

RECRUITING

Related Publications (2)

• Chuang IC, Chen IC, Wu YR, Li KY. Prediction and mediation analysis for treatment responses to combined cognitive and physical training for older adults. Sci Rep. 2024 May 8;14(1):10571. doi: 10.1038/s41598-024-61407-6.

  PMID: 38720025 DERIVED

• Chen IC, Chuang IC, Chang KC, Chang CH, Wu CY. Dual task measures in older adults with and without cognitive impairment: response to simultaneous cognitive-exercise training and minimal clinically important difference estimates. BMC Geriatr. 2023 Oct 16;23(1):663. doi: 10.1186/s12877-023-04390-3.

  PMID: 37845603 DERIVED

MeSH Terms

Conditions

Cognitive Dysfunction; Motor Activity

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Behavior

Study Officials

• Ching yi Wu, ScD

  Chang Gung Memorial Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ching yi Wu, ScD

CONTACT

#886-3-2118800; cywu@mail.cgu.edu.tw

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 29, 2020
• First Posted: December 30, 2020
• Study Start: September 16, 2020
• Primary Completion: January 1, 2023
• Study Completion: January 1, 2023
• Last Updated: July 5, 2022

Record last verified: 2022-06

Locations

TW (1)