Exercise to Slow Cardiovascular Ageing Progression

NCT05775484 | Recruiting

• 1 other identifier: 2022/2667
• Study Type: observational
• Target: 450
• Locations: 1 country
• Sites: 1

Brief Summary

In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing.

Conditions

Cardiac Ageing; Exercise; Cardiovascular

Outcome Measures

Primary Outcomes (2)

• Metabolite profiles

  To measure changes in serum metabolite levels among participants pre and post exercise intervention.

  12 Months

• Cardiovascular structure and function

  To measure changes in CV structure and function (diastolic function, arterial stiffness) among participants.

  12 Months

Study Arms (4)

A

1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography 2. Bio-specimen collection 3. Six-minute walk test 4. Musculoskeletal Analysis 5. Cardiopulmonary exercise test

B

1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography 2. Bio-specimen collection 3. Six-minute walk test 4. Musculoskeletal Analysis

C

1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography 2. Bio-specimen collection 3. Six-minute walk test 4. Musculoskeletal Analysis

D

1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography 2. Bio-specimen collection 3. Six-minute walk test (may require separate day visit to complete) 4. Musculoskeletal Analysis 5. Questionnaires

Eligibility Criteria

• Age: 21 Years - 100 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Recruited through research studies and community studies.

You may qualify if:

• Age \>=21 years old
• Outdoor ambulant

You may not qualify if:

• Wheelchair or bed-bound
• Dementia
• Residing in sheltered or nursing home
• Cancer
• Participation in ongoing clinical trials that involve interventional drugs or devices
• Aneurysms
• Acute infections (in the last six months)
• Uncontrolled thyrotoxicosis
• Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise
• Uncontrolled asthma or chronic lung disease
• Restrictive lung disease

Sponsors & Collaborators

• National Heart Centre Singapore: lead

Study Sites (1)

National Heart Centre Singapore

Singapore, Singapore, 169609, Singapore

RECRUITING

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2023
• First Posted: March 20, 2023
• Study Start: May 1, 2023
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2050
• Last Updated: June 5, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

SG (1)