The Cardio-Sarcopenia Study

NCT05203406 | Active Not Recruiting

• 1 other identifier: 2021/2263
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The use of surrogate markers such as body mass index (BMI) as a target outcome of physical activity may not be appropriate in older adults who are at risk of muscle sarcopenia. In the presence of sarcopenia, reductions in body weight may lead to lower BMI values. We have previously found deleterious changes in cardiac structure and function among sarcopenic older adults, raising a possible biological syndrome of 'cardio-sarcopenia'. In this study, we will investigate the impact of physical activity on temporal changes in cardiac and skeletal muscle , and BMI, over six- to twelve month period, on older adults with this syndrome. By targeting the cardio-sarcopenic phenotype as a modifiable risk factor that may be altered by physical activity, the results will provide new knowledge into retarding deleterious consequences of cardiovascular ageing. This new target challenges the paradigm of using BMI as an anthropometric marker in health prevention. If proven, this will dramatically change primary prevention targets among older adults, justifying the use of cardio-sarcopenia as a rational anthropometric target.

Conditions

Cardiac Ageing; Physical Activity; Older Adults; Sarcopenia

Keywords

aging; cardiovascular; skeletal muscle; sarcopenia; prevention; digital technology

Outcome Measures

Primary Outcomes (1)

• Changes in cardio-sarcopenia

  To compare differences in skeletal muscle (structure and function) and CV imaging markers, between older adults with low versus high physical activity levels, over time, at baseline and at six- to twelve months

  Six to twelve months

Secondary Outcomes (1)

• Changes in body mass index (BMI)

  Six to Twelve months

Other Outcomes (1)

• Changes in cardiac function as assessed by personalized digital health application.

  Six to Twelve month

Eligibility Criteria

• Age: 21 Years - 99 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Participants are recruited through population based studies (SingHealth IRB 2018/3173) who have agreed to be contacted for future studies.

You may qualify if:

• \>=21 years of age

You may not qualify if:

• Unable to provide written informed consent to participate in the study.

Sponsors & Collaborators

• National Heart Centre Singapore: lead

Study Sites (1)

National Heart Centre Singapore

Singapore, Singapore, 169609, Singapore

Location

Related Publications (1)

• Keng BMH, Gao F, Teo LLY, Lim WS, Tan RS, Ruan W, Ewe SH, Koh WP, Koh AS. Associations between Skeletal Muscle and Myocardium in Aging: A Syndrome of "Cardio-Sarcopenia"? J Am Geriatr Soc. 2019 Dec;67(12):2568-2573. doi: 10.1111/jgs.16132. Epub 2019 Aug 16.

  PMID: 31418823 BACKGROUND

MeSH Terms

Conditions

Motor Activity; Sarcopenia

Condition Hierarchy (Ancestors)

Behavior; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 10, 2022
• First Posted: January 24, 2022
• Study Start: May 1, 2022
• Primary Completion: December 31, 2023
• Study Completion (Estimated): December 31, 2051
• Last Updated: June 5, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

SG (1)