TO-ChERIsH: Trajectory of Cardiovascular Ageing, Its Determinants and Impact on Health

NCT04501562 | Active Not Recruiting

• 1 other identifier: 2019/2252
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Specific Aim 1: To determine longitudinal changes in CV ageing (changes in CV imaging) over time. Hypothesis: There are differences in rates of CV ageing over time. Specific Aim 2: To study determinants of CV ageing To assess how biological pathways affect CV ageing by studying the relationships between biological signatures measured in longitudinal biospecimens are associated with CV ageing. Hypothesis: Antecedent biological markers are associated with progression of CV ageing. Specific Aim 3: To determine the impact of CV ageing progression on the development of clinical CVD and the overall physical, cognitive and functional health of the elderly. Hypothesis: Those with stable CV imaging phenotypes have lower incidence of clinical CVD and also better overall health in ageing, compared to those with rapid deterioration (unhealthy CV ageing).

Conditions

Cardiac Ageing

Keywords

Echocardiogram; MRI/MRS

Outcome Measures

Primary Outcomes (1)

• To identifies functional and structural changes in the cardiovascular system that occur in during ageing.

  Health status will be tracked by telephone follow-up and/or matching at national disease registries at periodic intervals within one to five years, up to three decades.

  5 Years

Study Arms (1)

Subject

Other: Examinations; Other: Cardiovascular Tests; Other: Bio-specimen collection; Other: Clinical/health outcome collection

Interventions

Examinations OTHER

Participants will undergo focused examinations that include measurement of height, weight, waist circumference, body composition analysis, baseline data collection and blood pressure examinations. Resting electrocardiography will be performed to ascertain sinus rhythm.

Subject

Cardiovascular Tests OTHER

Specific quantitative cardiac ageing-related outcome parameters will be examined by multimodal techniques including two-dimensional transthoracic echocardiogram, and/or non-contrast magnetic resonance imaging/magnetic resonance spectroscopy.

Subject

Bio-specimen collection OTHER

Bio-specimens collected will include fresh blood, urine and/or stool specimens.

Subject

Clinical/health outcome collection OTHER

Health status will be tracked by telephone follow-up and/or matching at national disease registries at periodic intervals within one to five years, up to three decades.

Subject

Eligibility Criteria

• Age: 21 Years - 100 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants are recruited through population based studies (Singhealth IRB 2018/3173).

You may qualify if:

• \>= 21 years old

You may not qualify if:

• Unable to provide written informed consent to participate in the study

Sponsors & Collaborators

• National Heart Centre Singapore: lead

Study Sites (1)

National Heart Centre Singapore

Singapore, Singapore, 169609, Singapore

Location

MeSH Terms

Interventions

Restraint, Physical

Intervention Hierarchy (Ancestors)

Behavior Control; Therapeutics; Immobilization; Investigative Techniques

Study Officials

• Angela Koh, M.D.

  National Heart Centre Singapore

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 2, 2020
• First Posted: August 6, 2020
• Study Start: May 13, 2019
• Primary Completion (Estimated): December 1, 2049
• Study Completion (Estimated): December 1, 2049
• Last Updated: June 5, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

SG (1)