An Investigation of Different Type Single Limb Exercise Training Effects in Copd

NCT06471439 | Recruiting

• 1 other identifier: KA-22104
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

COPD presents not only respiratory symtoms but also vascular or muscle dysfunction. Exercise limitation is observed in COPD. Especially, decreased exercise performance related to vascular and fatique in quadriceps muscle. Exercise training is important for aerobic performance increasing. Generally results show exercise training with both lower limb. Increaed arterial stiffness and fatigue are observed in COPD. One leg exercise training result is not enough to highlight these parameters. Three types single leg exercise intervantion will be applied. Exercise capacity, muscle strength, lung function, electromyography, lactate and quality of life will be measured.

Conditions

Exercise

Keywords

Chronic Obstructive Pulmonary Disease; Single Limb exercise; resistance training; continous exercise training; high intensity exercise training

Outcome Measures

Primary Outcomes (1)

• six minute walk test

  six minute walk test in meter

  pre-intervention

Secondary Outcomes (9)

• cardiopulmonary exercise test

  beginning day 2

• one leg cardiopulmonary exercise test

  beginning, day 3

• quadriceps muscle strength assesing (repeated measeure)

  beginning day 1 and last day

• isometrics quadriceps muscle strength assesing

  beginning day 1 and last day

• lung function

  beginning day 1 and last day

Study Arms (3)

single leg resistance exercise intervantion in COPD

ACTIVE COMPARATOR

single leg resistance exercise intervantion in COPD will be perfomed at six weeks

Other: single leg exercise intervantion in COPD

single leg continous exercise intervantion in COPD

ACTIVE COMPARATOR

single leg continous exercise intervantion in COPD will be perfomed at six weeks

Other: single leg exercise intervantion in COPD

single leg high intensity exercise intervantion in COPD

ACTIVE COMPARATOR

single leg high intensity exercise intervantion in COPD will be perfomed at six weeks

Other: single leg exercise intervantion in COPD

Interventions

single leg exercise intervantion in COPD OTHER

single leg exercise intervantions 1. high intensity interval training 2. continous exercise training 3. resistance exercise training

Also known as: single leg exercise intervantion

single leg continous exercise intervantion in COPD; single leg high intensity exercise intervantion in COPD; single leg resistance exercise intervantion in COPD

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• COPD patients that applied to physiotherapy
• Cooperation for tests
• without severe ortopedical and neurological disease
• without severe cardiovascular disease
• To volunteer for the study.

You may not qualify if:

• have an acute exacerbation or having exacerbation at last month
• hypoxemia (PaO2\<55mmHg)
• no cooperated to test without volunteer to study having ortophedical and neurological diesase that affecting of tests severe cardiovascular disease

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Elif Kocaaga

Ankara, Turkey (Türkiye)

RECRUITING

Related Publications (3)

• Dolmage TE, Goldstein RS. Effects of one-legged exercise training of patients with COPD. Chest. 2008 Feb;133(2):370-6. doi: 10.1378/chest.07-1423. Epub 2007 Oct 9.

  PMID: 17925417 BACKGROUND

• Evans RA, Dolmage TE, Mangovski-Alzamora S, Romano J, O'Brien L, Brooks D, Goldstein RS. One-Legged Cycle Training for Chronic Obstructive Pulmonary Disease. A Pragmatic Study of Implementation to Pulmonary Rehabilitation. Ann Am Thorac Soc. 2015 Oct;12(10):1490-7. doi: 10.1513/AnnalsATS.201504-231OC.

  PMID: 26291542 BACKGROUND

• MacInnis MJ, Morris N, Sonne MW, Zuniga AF, Keir PJ, Potvin JR, Gibala MJ. Physiological responses to incremental, interval, and continuous counterweighted single-leg and double-leg cycling at the same relative intensities. Eur J Appl Physiol. 2017 Jul;117(7):1423-1435. doi: 10.1007/s00421-017-3635-8. Epub 2017 May 11.

  PMID: 28497384 BACKGROUND

MeSH Terms

Conditions

Motor Activity; Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Behavior; Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• elif kocaaga, ms

  Hacettepe University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

elif kocaaga, Ms

CONTACT

+903123052525; elifkocaaga86@gmail.com

elif kocaaga, Ms

CONTACT

+903123052525; elifkocaaga86@hotmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Model Details: three different type one leg exercise intervention are apllied in patients with copd

Study Record Dates

• First Submitted: May 17, 2024
• First Posted: June 24, 2024
• Study Start: June 16, 2023
• Primary Completion: January 2, 2025
• Study Completion: January 2, 2025
• Last Updated: June 24, 2024

Record last verified: 2024-06

Locations

TU (1)