A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome
LIBREXIA-ACS
A Phase 3, Randomized, Double-blind, Placebo-controlled, Event-driven Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, After a Recent Acute Coronary Syndrome
3 other identifiers
interventional
14,194
43 countries
985
Brief Summary
The purpose of this study is to evaluate that milvexian is superior to placebo, in addition to standard-of-care, in reducing the risk of major adverse cardiovascular event (MACE) (the composite of cardiovascular \[CV\] death, myocardial infarction \[MI\], and ischemic stroke).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Apr 2023
Typical duration for phase_3
985 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 23, 2023
CompletedFirst Posted
Study publicly available on registry
March 6, 2023
CompletedStudy Start
First participant enrolled
April 7, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 6, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
February 6, 2026
CompletedApril 13, 2026
April 1, 2026
2.8 years
February 23, 2023
April 9, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Time to First Occurrence of Major Adverse Cardiovascular Event (MACE)
Time to first occurrence of any component of MACE will be reported. MACE is a composite of cardiovascular (CV) death, myocardial infarction (MI), and ischemic stroke.
Up to 3 years 6 months
Secondary Outcomes (4)
Time to the First Occurrence of Major Adverse Vascular Event (MAVE)
Up to 3 years 6 months
Time to the First Occurrence of Composite of All-cause Mortality (ACM), Myocardial Infarction (MI) and Ischemic Stroke
Up to 3 years 6 months
Time to Cardiovascular (CV) Death
Up to 3 years 6 months
Time to All-cause Mortality (ACM)
Up to 3 years 6 months
Study Arms (2)
Milvexian
EXPERIMENTALParticipants enrolled within 7 days of an acute coronary syndrome (ACS), who have undergone cardiac catheterization with percutaneous intervention (PCI) or who are being managed conservatively with or without catheterization, and who are receiving antiplatelet therapy standard-of-care (single antiplatelet therapy \[SAPT\] or dual antiplatelet therapy \[DAPT\]) as determined by the investigator will receive milvexian 25 milligrams (mg), orally, twice daily.
Placebo
PLACEBO COMPARATORParticipants enrolled within 7 days of an ACS, who have undergone cardiac catheterization with PCI or who are being managed conservatively with or without catheterization, and who are receiving antiplatelet therapy standard-of-care (SAPT or DAPT) as determined by the investigator will receive placebo orally, twice daily.
Interventions
Eligibility Criteria
You may qualify if:
- Participants must have an index event that meets all 3 of the following criteria within 7 days prior to randomization: a) clinical syndrome consistent with spontaneous cardiac ischemia, b) diagnosis of acute coronary syndrome (ACS) (that is, ST-elevation myocardial infarction \[STEMI\], non-STEMI, or unstable angina \[UA\]), c) cardiac biomarker elevation (example, troponin I, troponin T, creatine kinase-MB \[CK-MB\]) above the upper limit of normal as determined by the local laboratory
- Participants must have at least 2 of the following risk factors:a) age 65 or older, b) diabetes mellitus, c) history of a prior myocardial infarction (MI) (other than index ACS event), d) multivessel coronary artery disease (CAD), e) history of coronary artery bypass graft (CABG) surgery prior to index ACS event, f) history of peripheral artery disease (PAD) or cerebrovascular disease (example, carotid atherosclerosis, intracranial artery stenosis, g) conservative management (that is, no percutaneous intervention \[PCI\] or CABG after index ACS event), h) Any one or more of the following high-risk angiographic features i) total stent length of greater than (\>) 30 millimeters (mm), ii) thrombotic target lesion, iii) bifurcation lesion treated with more than one stent, iv) calcified target lesion treated with atherectomy, v) treatment of obstructive left main or proximal left anterior descending artery for index ACS (or clinical diagnosis of an anterior STEMI)
- All female participants of childbearing potential must have a negative highly sensitive serum beta-human chorionic gonadotropin (hCG) or urine test at screening
- A female participant must not be pregnant, breastfeeding, or planning to become pregnant until 4 days (5 half-lives) after the last dose of study intervention
You may not qualify if:
- MI secondary to ischemia due to either increased oxygen demand or decreased supply (Type 2 MI) or periprocedural MI as the index ACS event
- Planned CABG or staged PCI after randomization
- Any condition that requires chronic anticoagulation at the discretion of the investigator and/or local guidelines
- Conditions with a significant increased risk of bleeding (example, clinically significant bleeding within previous 3 months, known bleeding diathesis, et cetera)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Janssen Research & Development, LLClead
- Bristol-Myers Squibbcollaborator
Study Sites (1003)
Advanced Cardiovascular, LLC
Alexander City, Alabama, 35010, United States
SORRA Research
Birmingham, Alabama, 35203, United States
Ascension St. Vincent's Health System
Birmingham, Alabama, 35205, United States
IMC-Diagnostic and Medical Clinic
Mobile, Alabama, 36604, United States
Cardiology Associates of Mobile Inc
Mobile, Alabama, 36608, United States
Mercy Gilbert Medical Center
Gilbert, Arizona, 85297, United States
Valleywise Health Medical Center
Phoenix, Arizona, 85008, United States
HonorHealth Neurology
Scottsdale, Arizona, 85258, United States
Arkansas Heart Hospital
Little Rock, Arkansas, 72211, United States
Bakersfield Memorial Hospital
Bakersfield, California, 93306, United States
Mission Cardiovascular Research Institute
Fremont, California, 94538, United States
Radin Cardiovascular Medical Group
Newport Beach, California, 92663, United States
Valley Clinical Trials, Inc.
Northridge, California, 91325, United States
Stanford University School of Medicine
Palo Alto, California, 94304, United States
VA Palo Alto Healthcare System
Palo Alto, California, 94304, United States
Huntington Hospital
Pasadena, California, 91105, United States
The Cardiovascular Center
Redding, California, 96001, United States
University Of California San Diego
San Diego, California, 92103, United States
San Diego Cardiac Center
San Diego, California, 92123, United States
VA San Diego Health Care System
San Diego, California, 92161, United States
UCLA
Santa Monica, California, 90401, United States
NorthBay Clinical Research, LLC
Santa Rosa, California, 95405, United States
Ramin Manshadi, MD
Stockton, California, 95204, United States
South Denver Cardiology Associates PC
Littleton, Colorado, 80120, United States
Nuvance Health Medical Practices Cardiology Danbury
Danbury, Connecticut, 06810, United States
Cardiology Associates of Fairfield County, P.C.
Stamford, Connecticut, 06905, United States
George Washington University Medical Center
Washington D.C., District of Columbia, 20037, United States
FWD Clinical Research
Boca Raton, Florida, 33434, United States
Clearwater Cardiovascular Consultants
Clearwater, Florida, 33756, United States
Holy Cross Hospital Inc.
Fort Lauderdale, Florida, 33308, United States
Integrative Research Associates
Fort Lauderdale, Florida, 33312, United States
University of Florida Health Jacksonville
Gainesville, Florida, 32610-0236, United States
Inpatient Research Clinic LLC
Hialeah, Florida, 33014, United States
Shands Jacksonville Medical Center Inc dba UF Health Jacksonville
Jacksonville, Florida, 32209, United States
Cardiology Partners Clinical Research Institute
Loxahatchee Groves, Florida, 33470, United States
Baptist Hospital of Miami
Miami, Florida, 33173, United States
Advanced Research for Health Improvement
Naples, Florida, 34102, United States
Amavita Clinical Research (Dr. Pedro Martinez-Clark)
North Miami Beach, Florida, 33169, United States
South Florida Research Solutions LLC
Pembroke Pines, Florida, 33028, United States
Coastal Cardiology Consultants
Safety Harbor, Florida, 34695, United States
Cardiovascular Center of Sarasota
Sarasota, Florida, 34239-3513, United States
Tampa Cardiovascular Interventions and Research
Tampa, Florida, 33614, United States
Interventional Cardiac Consultants
Trinity, Florida, 34655, United States
Cardiology Partners Clinical Research Institute 1
Wellington, Florida, 33449, United States
Grady Memorial Hospital
Atlanta, Georgia, 30303, United States
Atlanta Clinical Research Center
Cartersville, Georgia, 30121, United States
Northeast Georgia Heart Center
Gainesville, Georgia, 30501, United States
Cardiovascular Consultants of South Georgia LLC
Thomasville, Georgia, 31792, United States
Kootenai Medical Center
Coeur d'Alene, Idaho, 83814, United States
Insight Hospital and Medical Center Chicago
Chicago, Illinois, 60616, United States
Illinois Heart and Vascular Foundation
Chicago, Illinois, 60657, United States
Advocate Heart Institute
Downers Grove, Illinois, 60515, United States
Clinical Investigation Specialists, Inc.
Gurnee, Illinois, 60031, United States
Essential Concepts Research Solutions
Palos Hills, Illinois, 60465, United States
OSF HealthCare Cardiovascular Institute
Peoria, Illinois, 61614, United States
Methodist Medical Center of Illinois
Peoria, Illinois, 61636, United States
Prairie Cardiovascular Consultants, Ltd.
Springfield, Illinois, 62701, United States
Carle Foundation Hospital
Urbana, Illinois, 61801, United States
Midwest Cardiovascular Research Foundation
Elkhart, Indiana, 46514-2487, United States
Northern Indiana Research Alliance
Fort Wayne, Indiana, 46804, United States
IU Health Ball Memorial Hospital
Muncie, Indiana, 47303, United States
Reid Health
Richmond, Indiana, 47374, United States
Health Midwest Ventures Group, Inc d b a HCA MidAmerica Division, LLC
Overland Park, Kansas, 66209, United States
University of Louisville
Louisville, Kentucky, 40202, United States
Norton Cardiovascular Associates
Louisville, Kentucky, 40205, United States
Cambridge Medical Trials
Alexandria, Louisiana, 71301, United States
Cardiovascular Institute of the South
Houma, Louisiana, 70360, United States
Ochsner Clinic And Hospital
New Orleans, Louisiana, 70121, United States
Louisiana Heart Center
Slidell, Louisiana, 70458, United States
Monroe Research LLC
West Monroe, Louisiana, 71291, United States
Eastern Maine Medical Center Northeast Cardiology Associates
Bangor, Maine, 04401, United States
Johns Hopkins University School of Medicine
Baltimore, Maryland, 21231, United States
Suburban Hospital
Bethesda, Maryland, 20814, United States
Captiol Cardiology Associates
Lanham, Maryland, 20706, United States
Shady Grove Office
Rockville, Maryland, 20850, United States
Tidal Health Peninsula Regional Inc.
Salisbury, Maryland, 21801, United States
Pentucket Medical Associates
Haverhill, Massachusetts, 01830, United States
University of Michigan
Ann Arbor, Michigan, 48109, United States
St. Joseph Mercy Oakland
Bloomfield Hills, Michigan, 48302, United States
AAMRC
Flint, Michigan, 48504, United States
Jackson Heart Clinic
Jackson, Michigan, 39216, United States
Sparrow Clinical Research Institute
Lansing, Michigan, 48912-1811, United States
St. Luke's Cardiology Associates
Duluth, Minnesota, 55802-2207, United States
HealthEast Medical Research Institute
Saint Paul, Minnesota, 55102, United States
Mercy Medical Research Institute
Chesterfield, Missouri, 63017, United States
The Curators of the University of Missouri on behalf of University of Missouri Health Care
Columbia, Missouri, 65211, United States
North Kansas City Hospital
Kansas City, Missouri, 64116, United States
Spectrum Clinical Research
Kansas City, Missouri, 64118, United States
Cox Health
Springfield, Missouri, 65807, United States
Saint Louis University
St Louis, Missouri, 63110, United States
Bryan LGH Heart Institute
Lincoln, Nebraska, 68506, United States
Methodist Physicians Clinic Heart Consultants
Omaha, Nebraska, 68114, United States
University Medical Center of Southern Nevada
Las Vegas, Nevada, 89102, United States
Ash Research Clinic
Brick, New Jersey, 08724, United States
Englewood Health
Englewood, New Jersey, 07631, United States
Newark Beth Israel Medical Center
Newark, New Jersey, 07112, United States
Atlanticare Regional Medical Center
Pomona, New Jersey, 08240, United States
Cardio Metabolic Institute
Somerset, New Jersey, 08873, United States
Buffalo General Medical Center
Buffalo, New York, 14203-1154, United States
Jamaica Hospital Medical Center
Jamaica, New York, 11418, United States
Columbia University Medical Center
New York, New York, 10032, United States
Weil Cornell University
New York, New York, 10065, United States
Weill Cornell Medicine
New York, New York, 10065, United States
Hudson Valley Cardiovascular Practice, PC
Poughkeepsie, New York, 12601, United States
Cardiac Care & Vascular Medicine, PLLC
The Bronx, New York, 10469, United States
Westchester Medical Center
Valhalla, New York, 10532, United States
Clinical Trials of America 1
Cary, North Carolina, 27518, United States
UNC School of Medicine
Chapel Hill, North Carolina, 27599-5021, United States
The Moses H. Cone Memorial Hospital
Greensboro, North Carolina, 27401, United States
Atrium Health Wake Forest Baptist
High Point, North Carolina, 27262, United States
Clinical Trials of America
Lenoir, North Carolina, 28645, United States
Novant Health
Matthews, North Carolina, 28105, United States
Rex Hospital
Raleigh, North Carolina, 27607, United States
Sanford Cardiology
Sanford, North Carolina, 27330, United States
Trinity Medical Group
Minot, North Dakota, 58701, United States
Summa Health System
Akron, Ohio, 44304, United States
University of Cincinnati
Cincinnati, Ohio, 45267, United States
Metro Health Hospital
Cleveland, Ohio, 44109, United States
Ohio Health
Columbus, Ohio, 43214, United States
Kettering Medical Center
Kettering, Ohio, 45429, United States
The Heart House
Springfield, Ohio, 45504, United States
Ascension Medical Group - St. John Clinic Infectious Disease
Bartlesville, Oklahoma, 74006, United States
South Oklahoma Heart Research
Oklahoma City, Oklahoma, 73135, United States
St John Health System Inc
Tulsa, Oklahoma, 74104, United States
Advanced Cardiac Care
Bethlehem, Pennsylvania, 18017, United States
Chambersburg Hospital
Chambersburg, Pennsylvania, 17201, United States
Hamot Medical Center
Erie, Pennsylvania, 16507, United States
UPMC Pinnacle Health
Harrisburg, Pennsylvania, 17110, United States
St. Mary Medical Center
Langhorne, Pennsylvania, 19047, United States
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104, United States
Lankenau Institute for Medical Research
Wynnewood, Pennsylvania, 19096, United States
AnMed Health
Anderson, South Carolina, 29621, United States
Prisma Health
Greenville, South Carolina, 29065, United States
St. Francis Physician Services, Inc, DBA Upstate Cardiology Research
Greenville, South Carolina, 29607, United States
Carolina Cardiology Associates
Rock Hill, South Carolina, 29732, United States
Monument Health Clinical Research
Rapid City, South Dakota, 57701, United States
Erlanger Health System
Chattanooga, Tennessee, 37403, United States
Apex Cardiology
Jackson, Tennessee, 38301, United States
Ascension Saint Thomas West Hospital
Nashville, Tennessee, 37205, United States
Vanderbilt University
Nashville, Tennessee, 37232, United States
Parkway Cardiology Associates PC
Oak Ridge, Tennessee, 37830, United States
Amarillo Heart Clinical Research Institute
Amarillo, Texas, 79106, United States
PharmaTex Research
Amarillo, Texas, 79109, United States
Med Research, Inc.
El Paso, Texas, 79902, United States
Texas Tech University Health Sciences Center-El Paso
El Paso, Texas, 79905, United States
Baylor Scott and White Research Institute 1
Fort Worth, Texas, 76104, United States
East Texas Cardiology, PA
Houston, Texas, 77002, United States
Physician Research Network
Houston, Texas, 77027, United States
Vital Heart and Vein
Humble, Texas, 77338, United States
Texas Cardiology Research Center
Kingwood, Texas, 77339, United States
Ascension Texas Cardiovascular
Kyle, Texas, 78640, United States
Cardiovoyage
Sherman, Texas, 75090, United States
Northwest Heart Clinical Research, LLC.
Tomball, Texas, 77375, United States
Virginia Heart
Falls Church, Virginia, 22042, United States
Riverside Regional Medical Center
Newport News, Virginia, 23601, United States
Sentara Cardiovascular Research Institute
Norfolk, Virginia, 23507, United States
Winchester Medical Center
Winchester, Virginia, 22601, United States
Providence Regional Medical Center Everett
Everett, Washington, 98201, United States
Cardiac Surgery Group
Tacoma, Washington, 98405, United States
MultiCare Health System
Tacoma, Washington, 98405, United States
Mayo Clinic Health System
La Crosse, Wisconsin, 54601-4795, United States
Marshfield Clinic
Marshfield, Wisconsin, 54449, United States
Hospital Espanol De Bahia Blanca
Bahía Blanca, 8000, Argentina
Hospital Italiano Regional Del Sur
Bahía Blanca, B8001HXM, Argentina
Hospital Italiano de Buenos Aires
Buenos Aires, C1181ACH, Argentina
Sanatorio Finochietto
Buenos Aires, C1187AAN, Argentina
Hospital Britanico de Buenos Aires
Buenos Aires, C1280AEB, Argentina
Sanatorio Guemes
CABA, C1180AAX, Argentina
Centro Medico Dra. Laura Maffei - Investigacion Clinica Aplicada
Ciudad Autonoma Buenos Aires, 1425, Argentina
Instituto Cardiovascular de Buenos Aires
Ciudad Autonoma Buenos Aires, 1428, Argentina
Fundacion Favaloro
Ciudad Autonoma Buenos Aires, C1093AAS, Argentina
Clinica Adventista Belgrano
Ciudad Autonoma Buenos Aires, C1430EGF, Argentina
Clinica Coronel Suarez
Coronel Suárez, B7540GHD, Argentina
Clínica Chutro
Córdoba, 5000, Argentina
Hospital San Roque
Córdoba, 5000, Argentina
Sanatorio Duarte Quiroz
Córdoba, 5000, Argentina
Clinica Romagosa
Córdoba, X5000AAI, Argentina
Clinica Privada del Prado
Córdoba, X5000AAW, Argentina
Sanatorio Allende
Córdoba, X5000JHQ, Argentina
Sanatorio de la Canada
Córdoba, X5000, Argentina
Instituto Privado De Especialidades Medicas S.A. Fundacion J Robert Cade
Córdoba, X5002HWE, Argentina
Hospital Cordoba
Córdoba, X5004CDT, Argentina
Centro Medico Luquez
Córdoba, X5006IKK, Argentina
Hospital Privado Centro Medico de Cordoba
Córdoba, X5016KEH, Argentina
Hospital Italiano de La Plata
La Plata, B1900AXI, Argentina
Centro de Investigaciones Medicas Mar Del Plata
Mar del Plata, B7600FYK, Argentina
Sanatorio Modelo de Quilmes
Quilmes, B1878DKF, Argentina
Instituto Cardiovascular de Rosario
Rosario, S2000DSR, Argentina
Sanatorio Parque
Rosario, S2000SDV, Argentina
Hospital Italiano Garibaldi
Rosario, S2001ODA, Argentina
Hospital Provincial del Centenario
Rosario, S2002KDS, Argentina
Centro de Investigaciones Clinicas Salta
Salta, 4400, Argentina
Centro Cardiovascular Salta
Salta, 4406, Argentina
Hospital El Cruce
San Juan Bautista, B1888AAE, Argentina
Corporacion Medica de Gral. San Martin S.A.
San Martín, 1650, Argentina
Investigaciones Clinicas Tucuman
San Miguel de Tucumán, T4000ICL, Argentina
Estudios Clinicos de los Arroyos
San Nicolás, 2900, Argentina
Sanatorio Mayo SA
Santa Fe, S3000AZH, Argentina
Hospital José María Cullen
Santa Fe, S3000EOZ, Argentina
Sanatorio Medico de Diagnostico y Tratamiento
Santa Fe, S3000FUJ, Argentina
Sanatorio San Martin
Venado Tuerto, S2600KUE, Argentina
Clinica Privada Fusavim SRL
Villa María, X5900JKA, Argentina
Royal Adelaide Hospital
Adelaide, 5000, Australia
Flinders Medical Centre
Adelaide, 5042, Australia
Ballarat Base Hospital
Ballarat, 3350, Australia
Sunshine Coast University Hospital
Birtinya, 4575, Australia
Cairns Base Hospital
Cairns, 4870, Australia
Royal Prince Alfred Hospital
Camperdown, 2050, Australia
Concord Repatriation General Hospital
Concord, 2139, Australia
The Canberra Hospital
Garran, 2605, Australia
Royal Brisbane and Women's Hospital
Herston, 4029, Australia
Royal Hobart Hospital
Hobart, 7000, Australia
Nepean Hospital
Kingswood, 2747, Australia
Core Research Group
Milton, 4064, Australia
Fiona Stanley Hospital
Murdoch, 6150, Australia
Gold Coast University Hospital
Southport, 4215, Australia
Westmead Hospital
Sydney, 2145, Australia
Latrobe Regional Hospital
Traralgon, 3844, Australia
Wollongong Hospital
Wollongong, 2500, Australia
The Queen Elizabeth Hospital
Woodville South, 5011, Australia
KH St.Josef Braunau am Inn
Braunau am Inn, 5280, Austria
Landeskrankenhaus Feldkirch
Feldkirch, A-6807, Austria
LKH-Univ. Klinikum Graz
Graz, 8036, Austria
Krankenhaus der Elisabethinen Linz
Linz, 4020, Austria
AKH - Medizinische Universitat Wien
Vienna, 1090, Austria
Imeldaziekenhuis
Bonheiden, 2820, Belgium
AZ Klina
Brasschaat, 2930, Belgium
AZ Sint-Jan
Bruges, 8000, Belgium
C.H.U. Brugmann
Brussels, 1020, Belgium
CUB Hôpital Erasme
Brussels, 1070, Belgium
Universitair Ziekenhuis Brussel
Brussels, 1090, Belgium
Cliniques Universitaires Saint Luc
Brussels, 1200, Belgium
Ziekenhuis Oost-Limburg
Genk, 3600, Belgium
AZ Sint-Lucas
Ghent, 9000, Belgium
Jessa Ziekenhuis
Hasselt, 3500, Belgium
CHR de la Citadelle
Liège, 4000, Belgium
Az Sint-Maarten
Mechelen, 97770, Belgium
Heilig Hart Ziekenhuis Lier
Mol, 2400, Belgium
CHU Ambroise Pare
Mons, 7000, Belgium
AZ Delta
Roeselare, 8800, Belgium
AZ Turnhout
Turnhout, 2300, Belgium
Hospital Vera Cruz
Belo Horizonte, 30140-062, Brazil
IMINC Instituto Mineiro de Intervencao Cardiologica LTDA
Belo Horizonte, 30140-073, Brazil
Cardresearch - Cardiologia Assistencial
Belo Horizonte, 30150-240, Brazil
Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa
Belo Horizonte, 30380-090, Brazil
UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu
Botucatu, 18618-686, Brazil
Hospital do Coracao do Brasil
Brasília, 70390903, Brazil
Centro de Cardiologia Clinica e Pesquisa Doutora Juliana Souza Ltda CECAP Centro de Cardiologia Clinica
Brasília, 70710 149, Brazil
Sociedade Hospitalar Angelina Caron
Campina Grande do Sul, 83430-000, Brazil
C.E.C.-Centro Especializado em Cardiologia Ltda.- Loema Medicina e Bem Estar
Campinas, 13010-001, Brazil
Instituto de Pesquisa Clinica de Campinas
Campinas, 13060-080, Brazil
Sociedade Literaria e Caritativa Santo Agostinho Hospital Sao Jose
Criciúma, 88811-508, Brazil
Irmandade Santa Casa de Misericordia de Curitiba
Curitiba, 80010-030, Brazil
Associacao Paranaense de Cultura PUCPR
Curitiba, 80230-130, Brazil
Hospital Cardiológico Costantini
Curitiba, 80320-320, Brazil
Hospital Das Clinicas Da Universidade Federal De Goias
Goiânia, 74605-020, Brazil
Instituto do Coracao de Marília
Marília, 17515-000, Brazil
Instituto Atena de Pesquisa Clinica
Natal, 59020-035, Brazil
Instituto Mederi de Pesquisa e Saude
Passo Fundo, 99010-120, Brazil
Santa Casa de Misericordia de Pelotas
Pelotas, 96015 290, Brazil
Hospital Maternidade e Pronto Socorro Santa Lucia
Poços de Caldas, 37701-033, Brazil
Associacao Hospitalar Moinhos de Vento
Porto Alegre, 90035-001, Brazil
Hospital das Clinicas de Porto Alegre
Porto Alegre, 90035-903, Brazil
IMV Pesquisa Cardiologica Sociedade Simples HMD COR l
Porto Alegre, 90110-270, Brazil
Hospital Ernesto Dornelles
Porto Alegre, 90160-092, Brazil
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS
Porto Alegre, 90610-000, Brazil
Fundacao Universitaria de Cardiologia
Porto Alegre, 90620-001, Brazil
Hospital Nossa Senhora da Conceicao S A
Porto Alegre, 91350 200, Brazil
PROCAPE - Universidade de Pernambuco Pronto Socorro Cardiológico de Pernambuco prof Luiz Tavares
Recife, 50100-060, Brazil
Secretaria de Saude Hospital Agamenon Magalhaes
Recife, 52051-380, Brazil
Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP
Ribeirão Preto, 14098-900, Brazil
Hospital sao lucas
Rio de Janeiro, 22061-080, Brazil
Hospital Santa Izabel Santa Casa de Misericordia da Bahia
Salvador, 40050-410, Brazil
Instituto CardioPulmonar
Salvador, 40170310, Brazil
Fundacao Bahiana de Cardiologia
Salvador, 41810-010, Brazil
Hospital da Bahia
Salvador, 41810011, Brazil
Pesquisare Saude
Santo André, 09080-110, Brazil
CEMEC - Centro Multidisciplinar de Estudos Clínicos
São Bernardo do Campo, 09715-090, Brazil
Instituto de Cardiologia de Santa Catarina
São José, 88103-460, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base
São José do Rio Preto, 15090-000, Brazil
Irmandade Da Santa Casa De Misericordia De Sao Paulo
São Paulo, 01221-020, Brazil
FGM Clinica Paulista de Doencas Cardiovasculares Ltda
São Paulo, 01323 000, Brazil
Real e Benemerita Associacao Portuguesa de Beneficencia
São Paulo, 01323 900, Brazil
Hospital Alemao Oswaldo Cruz
São Paulo, 01323-903, Brazil
Instituto Dante Pazzanese de Cardiologia
São Paulo, 04012-909, Brazil
Hospital Das Clinicas Da Faculdade De Medicina Da USP
São Paulo, 05403-000, Brazil
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
São Paulo, 05652000, Brazil
Casa de Saude Santa Marcelina - Hospital Santa Marcelina
São Paulo, 08270-120, Brazil
Instituto de Moléstias Cardiovasculares Tatuí
Tatuí, 18270-170, Brazil
HC-UFTM - Hospital de Clínicas da Universidade Federal do Triângulo Mineiro
Uberaba, 38025-350, Brazil
Clinica Cardioped Ltda
Vitória, 29702-020, Brazil
CEDOES
Vitória, Espírito Santo, Brazil
Santa Casa de Misericórdia de Votuporanga
Votuporanga, 15500-003, Brazil
MHAT Puls
Blagoevgrad, 2700, Bulgaria
MHAT Heart and Brain
Burgas, 8000, Bulgaria
Multiprofile Hospital for Active Treatment Dr. Tota Venkova
Gabrovo, 5300, Bulgaria
Multiprofile Hospital for Active Treatment - Haskovo
Haskovo, 6300, Bulgaria
MHAT Uni Hospital
Panagyurishte, 4500, Bulgaria
SHATC Sveti Georgi-Pernik OOD
Pernik, 2300, Bulgaria
Multiprofile Hospital for Active Treatment Heart and Brain, Pleven
Pleven, 5800, Bulgaria
UMHAT 'Dr. Georgi Stranski', EAD
Pleven, 5800, Bulgaria
UMHAT 'Sv. Georgi' EAD
Plovdiv, 4002, Bulgaria
MHAT Sv. Karidad EAD
Plovdiv, 4004, Bulgaria
2th MHAT - Sofia
Sofia, 1202, Bulgaria
National Heart Hospital
Sofia, 1309, Bulgaria
Diagnostic Consultation Centre 'Alexandrovska' EOOD
Sofia, 1431, Bulgaria
UMHAT Prof. Dr. Aleksandar Chirkov
Sofia, 1431, Bulgaria
University Multiprofile Hospital for Active Treatment - Tsaritsa Yoanna - ISUL, EAD
Sofia, 1527, Bulgaria
UMHATEM N I Pirogov
Sofia, 1606, Bulgaria
University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD
Sofia, 1750, Bulgaria
UMHAT Sofia Med
Sofia, 1797, Bulgaria
UMHAT Prof. Dr. St. Kirkovich AD
Stara Zagora, 6003, Bulgaria
Foothills Hospital
Calgary, Alberta, T2N4N2, Canada
University of Alberta
Edmonton, Alberta, T6G 2B7, Canada
Surrey Memorial Hospital
Surrey, British Columbia, V2V 0C6, Canada
Vancouver General Hospital
Vancouver, British Columbia, V5Z 1M9, Canada
Saint Boniface General Hospital
Winnipeg, Manitoba, R2H 2A6, Canada
Dalhousie University
Halifax, Nova Scotia, B3J 3R4, Canada
Dr. Saul Vizel Cardiac Research Office
Cambridge, Ontario, N1R 7R1, Canada
Hamilton Health Sciences Corporation
Hamilton, Ontario, L8L 2X2, Canada
London Health Sciences Centre
London, Ontario, N6A 5A5, Canada
Southlake Regional Health Centre
Newmarket, Ontario, L3Y 2R2, Canada
Halton Healthcare Services Corporation
Oakville, Ontario, L6M 0L8, Canada
University of Ottawa Heart Institute
Ottawa, Ontario, K1Y 4W7, Canada
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2, Canada
Niagara Health System
St. Catharines, Ontario, L2S 0A9, Canada
Toronto Sunnybrook Hospital
Toronto, Ontario, M4N 3M5, Canada
Office of Dr. Anthony Glanz
Windsor, Ontario, N8X 5A6, Canada
Clinique de Cardiologie de Levis
Lévis, Quebec, G6V 4Z5, Canada
Centre de Recherche du CHUM
Montreal, Quebec, H2L 4M1, Canada
Montreal General Hospital
Montreal, Quebec, H3G 1A4, Canada
Montreal Heart Institute
Québec, Quebec, 00, Canada
Centre de Recherche Clinique de Quebec
Québec, Quebec, G1J 1Z6, Canada
Institut Universitaire De Cardiologie Et De Pneumologie De Québec
Québec, Quebec, G1V 4G5, Canada
CardioVasc HR
Saint-Jean-sur-Richelieu, Quebec, J3A1C3, Canada
CSSS du Sud de Lanaudiere - Hopital Pierre-Le Gardeur d/b/a CISSS de Lanaudiere
Terrebonne, Quebec, J6V 2H2, Canada
CIUSSS de la Mauricie-et-du-Centre-du-Quebec
Trois-Rivières, Quebec, G8Z 3R9, Canada
Royal University Hospital
Saskatoon, Saskatchewan, S7N 0W8, Canada
Quantum Research
Puerto Varas, 5551070, Chile
Centro de Investigacion Clinica Universidad Catolica de Chile CICUC
Santiago, 8330024, Chile
Centro de Estudios Cardiologicos y de Medicina Interna
Temuco, 4780000, Chile
Centro de Investigacion Clinica del Sur
Temuco, 4781156, Chile
Centro de Estudios Clinicos V Region Ltda
Viña del Mar, 2520997, Chile
Baotou Central Hospital
Baotou, 014040, China
Beijing Anzhen Hospital, Capital Medical University
Beijing, 100029, China
Peking University First Hospital
Beijing, 100034, China
Beijing Shijitan Hospital
Beijing, 100038, China
Beijing Friendship Hospital Capital Medical University
Beijing, 100050, China
Peking University Third Hospital
Beijing, 100083, China
Chinese PLA General Hospital
Beijing, 100853, China
The First Hospital of Jilin University
Changchun, 130021, China
Changzhou No 2 Peoples Hospital
Changzhou, 213000, China
West China Hospital Sichuan University
Chengdu, 610041, China
Sichuan Provincial Peoples Hospital
Chengdu, 610072, China
The First Affiliated Hospital of Chongqing Medical University
Chongqing, 400016, China
Dongguan People s Hospital
Dongguan, 523059, China
The First Affiliated Hospital of Fujian Medical University
Fuzhou, 350005, China
Guangdong Provincial People's Hospital
Guangzhou, 510080, China
The First Affiliated Hospital of Sun Yat-Sen University
Guangzhou, 510080, China
The Affiliated Hospital of Guizhou Medical University
Guiyang, 550000, China
GuiZhou Privicial Peoples Hospital
Guiyang, 550002, China
Zhejiang Provincial People's Hospital
Hangzhou, 310000, China
Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine
Hangzhou, 310006, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
Hangzhou, 310016, China
Anhui Province Hospital
Hefei, 230001, China
Huizhou Municipal Central Hospital
Huizhou, 516001, China
Qilu Hospital of Shandong University
Jinan, 250012, China
The Second Affiliated Hospital, Shandong University
Jinan, 250033, China
Shandong Jining No.1 People's Hospital
Jining, 272011, China
Lanzhou University Second Hospital
Lanzhou, 730030, China
Linfen Central Hospital
Linfen, 041000, China
The Second Affiliated Hospital of Nanchang University
Nanchang, 330006, China
Nanjing Drum Tower Hospital
Nanjing, 210000, China
Zhongda Hospital Southeast University
Nanjing, 210009, China
Jiangsu Province Hospital
Nanjing, 210029, China
The First Affiliated Hospital of Nanyang Medical College
Nanyang, 473000, China
Ningbo First Hospital
Ningbo, 315010, China
Shanghai Ninth Peoples Hospital
Shanghai, 200011, China
Shanghai Chest Hospital
Shanghai, 200030, China
Zhongshan Hospital Fudan University
Shanghai, 200032, China
The First Affiliated Hospital of Shantou University Medical
Shantou, 515041, China
Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
Shenzhen, 518052, China
The Second Affiliatted Hospital of Soochow University
Suzhou, 210009, China
The First Affiliated Hospital of Soochow University
Suzhou, 215006, China
Shanxi Cardiovascular Hospital
Taiyuan, 030013, China
Tianjin Medical University General Hospital
Tianjin, 300052, China
Tianjin People's Hospital
Tianjin, 300121, China
The Second Hospital Of Tianjin Medical University
Tianjin, 300211, China
Tianjin Chest Hospital
Tianjin, 300222, China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325000, China
Wenzhou Peoples Hospital
Wenzhou, 325000, China
The Central Hospital of Wuhan
Wuhan, 430014, China
Hubei Zhongshan Hospital The Third Peoples Hospital of Hubei Province
Wuhan, 430033, China
Wuxi People s Hospital
Wuxi, 214023, China
The First Affiliated Hospital of Xian Jiaotong University
Xi'an, 710061, China
The Third Affiliated Hospital of Xinxiang Medical University
Xinxiang, 453003, China
The Affiliated Hospital of Xuzhou Medical College
Xuzhou, China
Yanbian University Hospital
Yanji, 133000, China
Yichang Central Pepole's Hospital
Yichang, 443003, China
General Hospital of Ningxia Medical Hospital
Yinchuan, 750004, China
Affiliated Hospital Of Guangdong Medical University
Zhanjiang, 524001, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, 450052, China
Zhongshan City Peoples Hospital
Zhongshan, 528403, China
Affiliated Hospital of Zunyi Medical University
Zunyi, 563000, China
General Hospital Dubrovnik
Dubrovnik, 20000, Croatia
Special Hospital for medical rehabilitation
Krapinske Toplice, 49217, Croatia
Clinical Hospital Centre Rijeka
Rijeka, 51000, Croatia
General Hospital Slavonski Brod
Slavonski Brod, 35000, Croatia
Poliklinika Solmed
Zagreb, 10000, Croatia
University Hospital Dubrava
Zagreb, 10000, Croatia
Fakultni nemocnice Brno
Brno, 625 00, Czechia
Vojenska nemocnice Brno
Brno, 636 00, Czechia
Fakultni nemocnice u sv. Anny v Brne
Brno, 65691, Czechia
Nemocnice Ceske Budejovice a s
České Budějovice, 370 87, Czechia
Fakultni nemocnice Hradec Kralove
Hradec Králové, 500 05, Czechia
Kardiocentrum Vysocina CZ a.s.
Jihlava, 586 01, Czechia
Oblastní nemocnice Kolín
Kolín, 280 02, Czechia
Krajská nemocnice Liberec a.s.
Liberec, 46001, Czechia
Fakultni Nemocnice Ostrava
Ostrava-Poruba, 708 52, Czechia
Pardubicka krajska nemocnice a s
Pardubice, 530 03, Czechia
Fakultni nemocnice Plzen
Pilsen, 304 60, Czechia
Fakultni nemocnice Kralovske Vinohrady
Prague, 100 34, Czechia
Kardiologie Vinohrady s r o
Prague, 120 00, Czechia
Vseobecna fakultni nemocnice v Praze
Prague, 12808, Czechia
Institut klinicke a experimentalni mediciny
Prague, 14000, Czechia
Ustredni vojenske nemocnice Praha
Prague, 169 02, Czechia
Nemocnice Slany
Slaný, 274 01, Czechia
Nemocnice AGEL - Podlesi a.s.
Třinec, 73961, Czechia
Aarhus University Hospital
Aahus N, 8200, Denmark
Amager Hospital
Copenhagen S, 2300, Denmark
Bispebjerg Og Frederiksberg Hospital
Frederiksberg, 2000, Denmark
Herning Regional Hospital
Herning, 7400, Denmark
Holbæk Sygehus
Holbæk, 4300, Denmark
Hvidovre Hospital
Hvidovre, 2650, Denmark
Slagelse Sygehus
Slagelse, 4200, Denmark
Odense University Hospital
Svendborg, 5700, Denmark
Viborg Hospital
Viborg, 8800, Denmark
CHU Angers - Hopital Hotel Dieu
Angers, 49100, France
CH Prive Saint-Martin
Caen, 14050, France
CHRU de Tours - Hopital Trousseau
Chambray-lès-Tours, 37170, France
Centre Hospitalier Sud Francilien
Corbeil-Essonnes, 91106, France
Hopital Henri Mondor
Créteil, 94000, France
CHU Dijon
Dijon, 21033, France
CHU de Grenoble Hopital Albert Michallon
La Tronche, 38700, France
CH de Chartres - Hôpital Louis Pasteur
Le Coudray, 28630, France
CHRU de Lille Hopital Claude Huriez
Lille, 59037, France
Centre Hospitalier Saint Joseph Et Saint Luc
Lyon, 69007, France
Clinique Du Pont De Chaume
Montauban, 82017, France
CHU de Montpellier Hopital Saint Eloi
Montpellier, 34295, France
Centre Hospitalier Emile Muller
Mulhouse, 68051, France
CHU Nantes, Institut du thorax
Nantes, 44093, France
Centre Hospitalier Universitaire - de Nice - Hopital Pasteur
Nice, 06002, France
Hopital Caremeau
Nîmes, 30029, France
Hopital Lariboisiere
Paris, 75010, France
Hopital Saint-Antoine
Paris, 75012, France
Hôpital Bichat - Claude Bernard
Paris, 75018, France
Hopital Cochin
Paris, 75679, France
Centre Hospitalier de Pau
Pau, 64046, France
Hôpital du Haut Lévêque
Pessac, 33604, France
CHU Poitiers - Hopital la Miletrie
Poitiers, 86000, France
Hopital de Bicetre
Potigny, 14420, France
CHU Rouen Hopital Charles Nicolle
Rouen, 76031, France
Clinique Saint-Hilaire - Centre Frédéric Joliot
Rouen, 78000, France
Nouvel Hopital Civil - CHU Strasbourg
Strasbourg, 67200, France
Hopital Rangueil
Toulouse, 31059, France
CHU de Nancy - Hopital de Brabois
Vandœuvre-lès-Nancy, 54500, France
Hopital Andre Mignot
Versailles, 78157, France
Klinikum am Plattenwald
Bad Friedrichshall, 74177, Germany
Universitaetsklinikum Freiburg 1
Bad Krozingen, 79189, Germany
Universitaetsklinikum Freiburg
Bad Krozingen, 79189, Germany
Kerckhoff-Klinik Bad Nauheim
Bad Nauheim, 61231, Germany
Vivantes Klinikum Im Friedrichshain
Berlin, 10249, Germany
Charite Campus Benjamin Franklin
Berlin, 12200, Germany
Charité Campus Virchow
Berlin, 13353, Germany
Vivantes Humboldt Klinikum
Berlin, 13509, Germany
GFO Kliniken Bonn, Betriebsstaette St. Marien
Beuel, 53225, Germany
Klinikum Bielefeld
Bielefeld, 33604, Germany
Marienhausklinikum Eifel Bitburg
Bitburg, 54634, Germany
Universitatsklinikum Bonn
Bonn, 53127, Germany
Staedisches Klinikum Brandenburg
Brandenburg an der Havel, 14770, Germany
Hospital Bremen Mitte
Bremen, 28277, Germany
Regiomed Klinikum Coburg
Coburg, 96450, Germany
St. Johannes-Hospital
Dortmund, 44137, Germany
Staedtisches Klinikum Dresden Standort Dresden Friedrichstadt
Dresden, 01067, Germany
Katholisches Krankenhaus St. Josef gGmbH - Abtlg. für Gynäkologie
Erfurt, 99097, Germany
Klinikum der Johann Wolfgang Goethe -Universitaet
Frankfurt, 60590, Germany
Universitaetsmedizin Greifswald
Greifswald, 17475, Germany
Universitaetsklinikum Hamburg Eppendorf
Hamburg, 20246, Germany
Asklepios Klinik Barmbek
Hamburg, 22307, Germany
Asklepios Klinik St. Georg
Hamburg, 22587, Germany
Klinikum Leverkusen gGmbH
Leverkusen, 51375, Germany
Herzzentrum Ludwigshafen
Ludwigshafen, 67063, Germany
Klinikum Luedenscheid
Lüdenscheid, 58515, Germany
Universitätsklinikum Magdeburg
Magdeburg, 39120, Germany
Katholisches Klinikum Mainz; Innere Medizin I- Kardiologie
Mainz, 55131, Germany
Universitatsmedizin der Johannes Gutenberg Universitat Mainz
Mainz, 55131, Germany
Universitaetsklinikum Mannheim
Mannheim, 68167, Germany
Kliniken Maria Hilf GmbH
Mönchengladbach, 41063, Germany
Marienhaus Klinikum
Neuwied, 56564, Germany
Sana-Klinikum Remscheid GmbH
Remscheid, 42859, Germany
Universitaetsmedizin Rostock
Rostock, 18057, Germany
Universitaetsklinikum Tuebingen
Tübingen, 72076, Germany
Klinikum Worms gGmbH
Worms, 67550, Germany
Uni General Hospital of Alexandroupolis
Alexandroupoli, 68100, Greece
Henry Dunant Hospital
Athens, 115 26, Greece
General Hospital of Athens G Gennimatas
Athens, 115 27, Greece
Hippokration Hospital
Athens, 11527, Greece
General Hospital of Athens Attikon
Athens, 12462, Greece
General Hospital of Attiki 'KAT'
Athens, 14561, Greece
Athens Medical Center
Athens, 15125, Greece
General Per Hospital of Athens Asklipiio Voulas
Athens, 16673, Greece
University Hospital of Heraklion
Heraklion, 71110, Greece
University General Hospital of Ioannina
Ioannina, 45500, Greece
University Hospital Of Larissa
Larissa, 41110, Greece
General University Hospital of Patras
Pátrai, 26500, Greece
Ahepa University General Hospital of Thessaloniki
Thessaloniki, 54636, Greece
Hippokration Hospital 1
Thessaloniki, 54642, Greece
Papageorgiou General Hospital
Thessaloniki, 56429, Greece
Papanikolaou General Hospital of Thessaloniki
Thessaloniki, 57010, Greece
Budai Irgalmasrendi Korhaz
Budapest, 1023, Hungary
Semmelweis Egyetem
Budapest, 1085, Hungary
Gottsegen György Országos Kardiológiai Intézet
Budapest, 1096, Hungary
Bajcsy-Zsilinszky Kórház és Rendelőintézet
Budapest, 1106, Hungary
Semmelweis Egyetem Varosmajor Sziv es Ergyogyaszati Klinika
Budapest, 1122, Hungary
Debreceni Egyetem
Debrecen, 4032, Hungary
Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz
Gyula, 5700, Hungary
Somogy Megyei Kaposi Mor Oktato Korhaz
Kaposvár, 7400, Hungary
Bacs-kiskun Megyei Korhaz
Kecskemét, 6000, Hungary
Pecsi Tudomanyegyetem
Pécs, 7624, Hungary
Szegedi Tudományegyetem Áok Szent-Györgyi Albert Klinikai Központ
Szeged, 6725, Hungary
Tolna Megyei Balassa Janos Korhaz
Szekszárd, 7100, Hungary
Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointez
Szolnok, 5000, Hungary
Markusovszky Egyetemi Oktatokorhaz
Szombathely, 9700, Hungary
Belvarosi Egeszseghaz Kft. (Leda-Platan Maganklinika es Sebeszeti Kozpont)
Zalaegerszeg, 8900, Hungary
NHL Medical College (SVP Hospital IMSR)
Ahmedabad, 380006, India
Jawaharlal Nehru Medical College and Hospital
Aligarh, 202001, India
Sri Jayadeva Institute
Bangalore, 560069, India
KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre (MRC)
Belagavi, 590010, India
S.P.Medical College & AG of Hospitals
Bikaner, 334003, India
Tamil Nadu Government Multi Super Speciality Hospital
Chennai, 600002, India
Apollo Hospitals 1
Chennai, 600006, India
Batra Hospital And Medical Research Centre
Delhi, 110062, India
Osmania General Hospital
Hyderabad, 500012, India
Care Hospitals
Hyderbad, 500034, India
Lisie Hospital
Kochi, 682018, India
NRS Medical College
Kolkata, 700014, India
IPGMER and SSKM Hospital
Kolkata, 700020, India
Rabindranath Tagore International Institute of Cardiac Sciences
Kolkata, 700099, India
Dayanand Medical College & Hospital, Tagore Nagar, Civil Lines
Ludhiana, 141001, India
Kasturba Medical College Hospital
Mangalore, 575001, India
Seth G S Medical College and KEM Hospital
Mumbai, 400012, India
Arneja Heart Institute
Nagpur, 440010, India
Crescent Hospital & Heart Center
Nagpur, 440012, India
Central India Cardiology Hospital and Research Institute
Nagpur, 440015, India
All India Institute of Medical Sciences
New Delhi, 110029, India
Sir Ganga Ram Hospital
New Delhi, 110060, India
Indira Gandhi Institute of Medical Sciences
Patna, 800014, India
Ruby Hall Clinic
Pune, 411001, India
KEM Hospital & Research Centre
Pune, 411011, India
Nanjappa Hospital
Shimoga, 577205, India
Unicare Heart Institute
Surat, 395002, India
Government Siddhartha Medical College
Vijayawada, 520008, India
King George Hospital
Visakhapatnam, 530002, India
Haemek Medical Center
Afula, 18101, Israel
Samson Assuta Ashdod University Hospital
Ashdod, 7747629, Israel
Barzilai Medical Center
Ashkelon, 78278, Israel
Soroka University Medical Center
Beersheba, 84101, Israel
Bnai Zion Medical Center
Haifa, 31048, Israel
Rambam Health Care Campus
Haifa, 31096, Israel
Carmel Medical Center
Haifa, 3436212, Israel
Wolfson Medical Center
Holon, 58100, Israel
Shaare Zedek Medical Center
Jerusalem, 9103102, Israel
Hadassah University Hospita Ein Kerem
Jerusalem, 9112001, Israel
Hadassah Medical Center
Jerusalem, 9124001, Israel
Meir Medical Center
Kfar Saba, 4428164, Israel
Health Corporation of Galilee Medical Center
Naharya, 2633737, Israel
Rabin Medical Center
Petah Tikva, 49100, Israel
Chaim Sheba Medical Center
Ramat Gan, 5262001, Israel
Kaplan Medical Center
Rehovot, 7610001, Israel
Assaf Harofeh Medical Center
Rishon LeZiyyon, 70300, Israel
Ziv Medical Center
Safed, 13100, Israel
Baruch Padeh Medical Center
Tiberias, 15208, Israel
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo Alessandria
Alessandria, 15121, Italy
Cliniche Humanitas Gavazzeni
Bergamo, 24125, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII)
Bergamo, 24127, Italy
Azienda USL di Bologna - Ospedale Maggiore
Bologna, 40100, Italy
Universita D Annunzio
Chieti, 66013, Italy
Azienda Ospedaliero-Universitaria di Ferrara Arcispedale Sant Anna
Ferrara, 44123, Italy
Ospedale Sant'Andrea
La Spezia, 19021, Italy
Azienda Ulss 3 Serenissima distretto di Mirano
Mestre, 30035, Italy
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Milan, 20122, Italy
Centro Cardiologico Monzino
Milan, 20138, Italy
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda)
Milan, 20162, Italy
Azienda Ospedaliera Universitaria Federico II
Naples, 80131, Italy
Azienda Ospedaliero Universitaria di Parma
Parma, 43100, Italy
Fondazione IRCCS Policlinico San Matteo
Pavia, 27100, Italy
A. O.U. Pisana Ospedale di Cisanello
Pisa, 56124, Italy
AOU Policlinico Umberto I
Roma, 00161, Italy
Fondazione Policlinico Universitario A Gemelli IRCCS
Roma, 00168, Italy
Istituto Clinico Humanitas
Rozzano, 20089, Italy
Ospedale San Francesco
Sassari, 07100, Italy
Ospedale Bolognini
Seriate, 24068, Italy
IRCCS Multimedica di Sesto San Giovanni
Sesto San Giovanni, 20099, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti
Torrette Di Ancona, 60126, Italy
Azienda Ospedaliera Ospedale Treviglio-Caravaggio di Treviglio
Treviglio, 24047, Italy
Kasugai Municipal Hospital
Aichi, 486-8510, Japan
Hyogo Prefectural Amagasaki General Medical Center
Amagasaki Shi, 660 8550, Japan
Chiba University Hospital
Chiba, 260 8677, Japan
Funabashi Municipal Medical Center
Chiba, 273 8588, Japan
Saiseikai Futsukaichi Hospital
Chikushino-shi, 818-8516, Japan
Fukui Prefectural Hospital
Fukui-shi, 910-8526, Japan
National Hospital Organization Kyushu Medical Center
Fukuoka, 810 8563, Japan
Fukuoka Wajiro Hospital
Fukuoka, 811-0213, Japan
Kyushu University Hospital
Fukuoka, 812-8582, Japan
Gifu Prefectural General Medical Center
Gifu, 500-8717, Japan
National Hospital Organization Takasaki General Medical Center
Gunma, 370-0829, Japan
Hyogo Prefectural Harima-Himeji General Medical Center
Himeji-shi, 670-8560, Japan
Hiratsuka Kyosai Hospital
Hiratsuka-shi, 254-8502, Japan
Hirosaki University Hospital
Hirosaki, 036-8203, Japan
Hiroshima City Hiroshima Citizens Hospital
Hiroshima, 730-8518, Japan
Tokai University Hospital
Isehara, 259-1193, Japan
Public Central Hospital of Matto Ishikawa
Ishikawa, 924-0865, Japan
Teikyo University Hospital
Itabashi Ku, 173 8606, Japan
Juntendo University Shizuoka Hospital
Izunokuni-shi, 410-2295, Japan
Tesshokai Kameda Clinic
Kamogawa, 2960041, Japan
Showa University Fujigaoka Hospital
Kanagawa, 227-8501, Japan
Asanokawa, Kanazawa Cardiovascular Hospital
Kanazawa, 920-0007, Japan
Fukuoka Tokushukai Hospital
Kasuga-shi, 816-0864, Japan
Kimitsu Chuo Hospital
Kisarazu-shi, 292-8535, Japan
Kokura Memorial Hospital
Kitakyushu-shi, 802-8555, Japan
Chikamori Hospital
Kochi, 780-8522, Japan
National Hospital Organization Fukuoka Higashi Medical Center
Koga, 811-3195, Japan
Kumamoto University Hospital
Kumamoto, 860-8556, Japan
Saiseikai Kumamoto Hospital
Kumamoto, 861-4193, Japan
Kurashiki Central Hospital
Kurashiki, 710-8602, Japan
National Hospital Organization Kure Medical Center and Chugoku Cancer Center
Kure-shi, 736-0023, Japan
Kyoto University Hospital
Kyoto, 606-8507, Japan
National Hospital Organization Kyoto Medical Center
Kyoto, 612-8555, Japan
Tokushukai Chiba-Nishi General Hospital
Matsudo-shi, 270-2251, Japan
Jisenkai Aizawa Hospital
Matsumoto-shi, 390-8510, Japan
Toho University Medical Center, Ohashi Hospital
Meguro-ku, 153-8515, Japan
Tokyo Saiseikai Central Hospital
Minatoku, 108-0073, Japan
Miyazaki Medical Association Hospital
Miyazaki, 880-2102, Japan
NHO Nagoya Medical Center
Nagoya, 460-0001, Japan
Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital
Nagoya, 466-8650, Japan
Hyogo Medical University Hospital
Nishinomiya Shi, 663 8501, Japan
Okayama Rosai Hospital
Okayama, 702-8055, Japan
Osaka City General Hospital
Osaka, 534-0021, Japan
National Hospital Organization Osaka National Hospital
Osaka, 540-0006, Japan
Osaka Police Hospital
Osaka, 543-0035, Japan
Saga University Hospital
Saga, 849-8501, Japan
Kitasato University Hospital
Sagamihara, 252-0375, Japan
National Hospital Organization Saitama National Hospital
Saitama, 351-0102, Japan
Iwatsuki Minami Hospital
Saitama-shi, 339-0033, Japan
Tohoku University Hospital
Sendai, 980 8574, Japan
Showa University Hospital
Shinagawa City, 142 8666, Japan
Tokyo Women's Medical University Hospital
Shinjuku-ku, 162-8666, Japan
Iwate Medical University Hospital
Shiwa-gun, 028-3695, Japan
National Cerebral and Cardiovascular Center
Suita-Shi, 564-8565, Japan
Kagawa Prefectural Central Hospital
Takamatsu, 760-8557, Japan
Tokushima University Hospital
Tokushima, 770-8503, Japan
Mitsui Memorial Hospital
Tokyo, 101-8643, Japan
St. Luke's International Hospital
Tokyo, 104 8560, Japan
Nippon Medical School Hospital
Tokyo, 113 8603, Japan
National Hospital Organization Tokyo Medical Center
Tokyo, 152-8902, Japan
Nihon University Itabashi Hospital
Tokyo, 173 8610, Japan
Ome Medical Center
Tokyo, 198-0042, Japan
Toyama Prefectural Central Hospital
Toyama, 930-8550, Japan
Mie University Hospital
Tsu, 514-8507, Japan
Tsuchiura Kyodo General Hospital
Tsuchiura, 300-0028, Japan
Tsukuba Medical Center Hospital
Tsukuba, 305 8558, Japan
Yamaguchi University Hospital
Ube, 755-8505, Japan
Tokyo Bay Urayasu Ichikawa Medical Center
Urayasu-shi, 279-0001, Japan
National Hospital Organization Ureshino Medical Center
Ureshino-shi, 843-0393, Japan
Wakayama Medical University Hospital
Wakayama, 641 8510, Japan
Yokohama City University Medical Center
Yokohama, 232 0024, Japan
Daugavpils Regional Hospital
Daugavpils, LV5417, Latvia
Riga East Clinical University Hospital
Riga, LV-1038, Latvia
Pauls Stradins Clinical University Hospital
Riga, LV1002, Latvia
Hospital of Lithuanian University of Health Sciences Kaunas Clinics
Kaunas, LT-50161, Lithuania
Klaipeda Seamen's Hospital, Public Institution
Klaipėda, LT-92288, Lithuania
Vilnius University Hospital Santariskiu Clinic, Public Institution
Vilnius, LT-08661, Lithuania
Hospital University Sains Malaysia
Kota Bharu, 15200, Malaysia
Hospital Raja Perempuan Zainab Ii
Kota Bharu, 15586, Malaysia
Hospital Queen Elizabeth
Kota Kinabalu, 88500, Malaysia
Institut Jantung Negara
Kuala Lumpur, 50400, Malaysia
Pusat Perubatan Universiti Kebangsaan Malaysia
Kuala Lumpur, 56000, Malaysia
University Malaya Medical Centre
Kuala Lumpur, 59100, Malaysia
Sarawak General Hospital
Kuching, 93200, Malaysia
Hospital Miri
Miri, 98000, Malaysia
Hospital Pulau Pinang
Pulau Pinang, 10990, Malaysia
Hospital Seberang Jaya
Seberang Jaya, 13700, Malaysia
Universiti Teknologi Mara
Selayang Baru Utara, 68000, Malaysia
Hospital Cardiologica Aguascalientes
Aguascalientes, 20230, Mexico
Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada S.C.
Culiacán, 80230, Mexico
Centro de Estudios de de alta Especialidad de Sinaloa
Mazatlán, 82126, Mexico
Instituto Nacional de Cardiologia Dr. Ignacio Chavez
México, 14080, Mexico
Private Practice Dr Amaya
Monterrey, 64718, Mexico
Centro de Estudios Clinicos de Queretaro S.C
Querétaro, 76000, Mexico
Centro de Atencion e Investigacion Cardiovascular del Potosi S C
San Luis Potosí City, 78200, Mexico
Centro de Investigacion Cardiovascular y Metabolica
Tijuana, 22500, Mexico
Centro de Investigacion Dr. Alberto Esteban Bazzoni Ruiz
Torreón, 27000, Mexico
Dr Enrique Lopez Rosas
Xalapa, 91193, Mexico
Jeroen Bosch Ziekenhuis
's-Hertogenbosch, 5223 GZ, Netherlands
Noordwest Ziekenhuisgroep
Alkmaar, 1815 JD, Netherlands
Ziekenhuisgroep Twente
Almelo, 7609PP, Netherlands
Meander Medisch Centrum
Amersfoort, 3813 TZ, Netherlands
Onze Lieve Vrouwe Gasthuis
Amsterdam, 1091 AC, Netherlands
Deventer Ziekenhuis
Deventer, 7416 SE, Netherlands
Ziekenhuis Gelderse Vallei
Ede, 6716 RP, Netherlands
Catharina Ziekenhuis
Eindhoven, 5623 EJ, Netherlands
Treant Zorggroep
Emmen, 7824 AA, Netherlands
Medisch Spectrum Twente
Enschede, 7512 KZ, Netherlands
Admiraal De Ruyter Ziekenhuis - Goes
Goes, 4462 RA, Netherlands
Groene Hart Ziekenhuis
Gouda, 2803 HH, Netherlands
Ziekenhuis St Jansdal
Harderwijk, 3844 DG, Netherlands
Zuyderland Medical Center
Heerlen, 6419 PC, Netherlands
Elkerliek Ziekenhuis
Helmond, 5707 HA, Netherlands
Alrijne Ziekenhuis Leiden ; Cardiology
Leiderdorp, 2353 GA, Netherlands
Maastricht UMC
Maastricht, 6229 HX, Netherlands
St. Antonius Ziekenhuis Nieuwegein
Nieuwegein, 3435 CM, Netherlands
Radboudumc
Nijmegen, 6525GA, Netherlands
Bravis
Roosendaal, 4708 AE, Netherlands
Sint Franciscus Gasthuis
Rotterdam, 3045 PM, Netherlands
D & A Research
Sneek, 8601 ZR, Netherlands
Ziekenhuis Rivierenland
Tiel, 4002 WA, Netherlands
Diakonessenhuis
Utrecht, 3582 KE, Netherlands
Maxima Medisch Centrum
Veldhoven, 5504 DB, Netherlands
VieCuri Medisch Centrum
Venlo, 5912 BL, Netherlands
Gelre Ziekenhuizen Zutphen
Zutphen, 7207, Netherlands
North Shore Hospital
Auckland, 0740, New Zealand
Auckland City Hospital
Auckland, 1030, New Zealand
University of Otago
Christchurch, 4710, New Zealand
Dunedin Public Hospital
Dunedin, 9016, New Zealand
Hawkes Bay Hospital
Hastings, 4120, New Zealand
Taranaki Base Hospital
New Plymouth, 4342, New Zealand
Middlemore Hospital
Otahuhu, 2025, New Zealand
Rotorua Hospital
Rotorua, 3010, New Zealand
Tauranga Hospital
Tauranga, 3143, New Zealand
Whangarei Hospital
Whangarei, 110, New Zealand
University Clinic of Cardiology
Skopje, 1109, North Macedonia
Clinical Hospital Tetovo
Tetovo, 1200, North Macedonia
The Heart Specialists Clinic and Diagnostic Center
Angeles, 2009, Philippines
Silang Specialists Medical Center
Cavite, 4118, Philippines
Cebu Doctors University Hospital
Cebu, 6000, Philippines
Central Lab Diabetes Wellness, Heart and Kidneys, Inc
Davao City, 8000, Philippines
Davao Doctors Hospital
Davao City, 8000, Philippines
Southern Philippines Medical Center
Davao City, 8000, Philippines
St.Paul's Hospital-Iloilo
Iloilo City, 5000, Philippines
Mary Mediatrix Medical Center
Lipa City, 4217, Philippines
Health Cube Medical Clinics
Mandaluyong, 1552, Philippines
Manila Doctors Hospital
Manila, 1000, Philippines
Medical Center Manila
Manila, 1000, Philippines
Philippine General Hospital 1
Manila, 1000, Philippines
Chinese General Hospital & Medical Center
Manila, 1003, Philippines
Amang Rodriguez Memorial Medical Center
Marikina City, 1800, Philippines
The Medical City
Pasig, 1605, Philippines
St. Luke's Medical Center 1
Quezon, 1102, Philippines
Cardinal Santos Medical Center
San Juan City, 1502, Philippines
The Medical City South Luzon
Santa Rosa, 4026, Philippines
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, 15 276, Poland
NZOZ Centrum Medyczne KERmed
Bydgoszcz, 85 231, Poland
Samodzielny Publiczny Zaklad Opieki Zdrowotnej
Bytom, 41 902, Poland
Wojewodzki Szpital Zespolony w Elblagu
Elblag, 82 300, Poland
Clinical Medical Research Sp. z o.o.
Katowice, 40-156, Poland
Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego
Kielce, 25-525, Poland
Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
Krakow, 30-082, Poland
Krakowskie Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii
Krakow, 30-693, Poland
Krakowski Szpital Specjalistyczny im Jana Pawla II
Krakow, 31 202, Poland
SPZOZ Centralny Szpital Kliniczny UM w Lodzi
Lodz, 92-213, Poland
1 Wojskowy Szpital Kliniczny Z Poliklinika SPZOZ W Lublinie
Lublin, 20 049, Poland
Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie
Lublin, 20-954, Poland
NZOZ Osrodek Kardiologii Inwazyjnej -Ikardia
Nałęczów, 24-140, Poland
Wojewodzki Szpital Specjalistyczny w Olsztynie
Olsztyn, 10 561, Poland
FutureMeds Olsztyn
Olsztyn, 10-010, Poland
Medicome Sp. Z O.O.
Oświęcim, 32-600, Poland
Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
Poznan, 61 848, Poland
Wojewodzki Szpital im Sw Ojca Pio w Przemyslu
Przemyśl, 37-700, Poland
Samodzielny Publiczny Szpital Wojewodzki im. Papieza Jana Pawla II
Siedlce, 08-110, Poland
ETG Skierniewice
Skierniewice, 96-100, Poland
NZOZ PRO CORDIS Sopockie Centrum Badan Kardiologicznych
Sopot, 81 717, Poland
Wojewodzki Szpital Zespolony im L Rydygiera w Toruniu
Torun, 87 100, Poland
Narodowy Instytut Kardiologii Stefana kardynala Wyszynskiego Panstwowy Instytut Badawczy
Warsaw, 04-628, Poland
Specjalistyczny Szpital im dra Alfreda Sokolowskiego w Walbrzychu
Wałbrzych, 58 309, Poland
Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu
Wroclaw, 50 368, Poland
4 Wojskowy Szpital Kliniczny Z Poliklinika SP ZOZ
Wroclaw, 50 981, Poland
Wojewodzki Szpital Specjalistyczny we Wroclawiu
Wroclaw, 51 124, Poland
Centro Hospitalar do Baixo Vouga E P E Unidade de Aveiro
Aveiro, 3814-501, Portugal
Hospital de Braga
Braga, 4710-243, Portugal
Uls Coimbra - Hosp. Univ. Coimbra
Coimbra, 3000-075, Portugal
Centro Hospitalar Cova da Beira, EPE - Hospital Pêro da Covilhã
Covilha, 6200-074, Portugal
Uls Alto Ave - Hosp. Sra. Da Oliveira Guimaraes
Guimarães, 4835 044, Portugal
Centro Hospitalar de Leiria
Leiria, 2410-197, Portugal
Centro Hospitalar de Lisboa Central
Lisbon, 1169-024, Portugal
Centro Hospitalar de Lisboa Norte Hospital Santa Maria
Lisbon, 1649-035, Portugal
Centro Hospitalar de Entre o Douro e Vouga, E.P.E
Santa Maria da Feira, 4520-211, Portugal
Centro Hospitalar de Vila Nova de Gaia Espinho E P E
Vila Nova de Gaia, 4434-502, Portugal
Centro Hospitalar de Trás os Montes e Alto Douro- Vila Real
Vila Real, 5000-508, Portugal
Spitalul Judetean de Urgenta Dr. Constantin Opris
Baia Mare, 430031, Romania
Spitalul Clinic Judetean de Urgenta Brasov
Brasov, 500326, Romania
Spitalul Universitar de Urgenta Militar Central 'Dr. Carol Davila'
Bucharest, 010825, Romania
Spitalul Universitar de Urgenta Elias, Clinica de Cardiologie
Bucharest, 011461, Romania
Spitalul Clinic de Urgenta Bucuresti
Bucharest, 014461, Romania
Institutul de urgenta pentru Boli Cardiovasculare Prof. Dr. C.C. Iliescu
Bucharest, 022328, Romania
Spitalul Angiocare SRL
Cluj-Napoca, 400000, Romania
Spitalul Clinic Judetean de Urgenta Cluj Napoca
Cluj-Napoca, 400006, Romania
Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei
Constanța, 900591, Romania
Spitalul Clinic Judetean de Urgenta Craiova
Craiova, 200147, Romania
Institutul de Boli Cardiovasculare Iasi
Iași, 700503, Romania
Spitalul Clinic Judetean de Urgenta Oradea
Oradea, 410167, Romania
SAL MED Pitesti
Piteşti, 110424, Romania
Spitalul Clinic Judetean de Urgenta Targu Mures 1
Târgu Mureş, 540136, Romania
Spitalul Clinic Judetean de Urgenta Targu Mures
Tg. Mures, 540136, Romania
Clinica Medicaliss
Timișoara, 300043, Romania
Spitalul Clinic Municipal de Urgenta Timisoara
Timișoara, 300079, Romania
Institutul de Boli Cardiovasculare Timisoara
Timișoara, 300310, Romania
Clinical Center Dr Dragisa Misovic Dedinje
Belgrade, 11000, Serbia
Institute for Cardiovascular diseases Dedinje 1
Belgrade, 11000, Serbia
Institute for Cardiovascular diseases Dedinje
Belgrade, 11000, Serbia
University Clinical Center of Serbia 1
Belgrade, 11000, Serbia
University Clinical Center of Serbia 2
Belgrade, 11000, Serbia
University Clinical Center of Serbia
Belgrade, 11000, Serbia
Clinical Hospital Center Zemun
Belgrade, 11080, Serbia
University Clinical Hospital Center Dr Dragisa Misovic- Dedi
Belgrade, 11080, Serbia
Institute of Cardiovascular Diseases of Vojvodina 1
Kamenitz, 21204, Serbia
Institute of Cardiovascular Diseases of Vojvodina
Kamenitz, 21204, Serbia
University Clinical Center Kragujevac
Kragujevac, 34000, Serbia
Clinical Center Nis 1
Niš, 18000, Serbia
Clinical Center Nis
Niš, 18000, Serbia
Institute for Treatment and Rehabilitation Niska Banja
Niška Banja, 18205, Serbia
General Hospital Pancevo
Pančevo, 26000, Serbia
General Hospital Smederevo
Smederevo, 11300, Serbia
General Hospital Sremska Mitrovica
Sremska Mitrovica, 22000, Serbia
General Hospital Uzice
Užice, 31000, Serbia
Health Center Zajecar
Zaječar, 19000, Serbia
National University Hospital
Singapore, 119074, Singapore
National Heart Centre (NHC) Singapore
Singapore, 169609, Singapore
Changi General Hospital
Singapore, 529889, Singapore
Ng Teng Fong General Hospital
Singapore, 609606, Singapore
Khootech Puat Hospital
Singapore, 768828, Singapore
Stredoslovensky ustav srdcovych a cievnych chorob a.s
Banská Bystrica, 97401, Slovakia
Alian s.r.o.
Bardejov, 08501, Slovakia
Premedix Clinic
Bratislava, 811 02, Slovakia
Nemocnica s poliklinikou Brezno
Brezno, 977 01, Slovakia
Východoslovenský Ústav Srdcových A Cievnych Chorôb, A.S.
Košice, 040 11, Slovakia
Interno Kardio s r o
Košice, 04001, Slovakia
Kardiologicka ambulancia CARDIO D&R s.r.o.
Košice, 4022, Slovakia
Kardio 1 S.R.O.
Lučenec, 98439, Slovakia
Univerzitna nemocnica Martin 1
Martin, 036 59, Slovakia
Kardiologicka ambulancia MEDI M&M s.r.o.
Moldava nad Bodvou, 4501, Slovakia
Kardiocentrum Nitra s.r.o.
Nitra, 95001, Slovakia
Cardioinvest s.r.o.
Nové Zámky, 94052, Slovakia
Interna SK s.r.o.
Svidník, 08901, Slovakia
Nemocnica AGEL Zvolen a s
Zvolen, 960 01, Slovakia
MEDIVASA s.r.o.
Žilina, 01001, Slovakia
Panorama MediClinic
Cape Town, 7500, South Africa
Tread Research
Cape Town, 7500, South Africa
Tiervlei Trial Centre
Cape Town, 7530, South Africa
Groote Schur Hospital
Cape Town, 7925, South Africa
Johese Clinical Research
Centurion, 0157, South Africa
Durban Medical Centre
Durban, 4001, South Africa
Garda, RA
Johannesburg, 2192, South Africa
Eden Heart
Mossel Bay, 6506, South Africa
Dr J.M. Engelbrecht Trial Site
Somerset West, 7130, South Africa
Helderberg Research Institute
Somerset West, 7130, South Africa
Clinical Projects Research SA (PTY) LTD
Worcester, 6850, South Africa
Bucheon St. Mary's Hospital
Bucheon-si, 14647, South Korea
Inje University Busan Paik Hospital
Busan, 47392, South Korea
Pusan National University Hospital
Busan, 49241, South Korea
Dong-A University Hospital
Busan, 602 812, South Korea
Chungbuk National University Hospital
Cheongju-si, 28644, South Korea
Kangwon National University Hospital
Chuncheon, 24289, South Korea
Keimyung University Dongsan Hospital
Daegu, 42601, South Korea
Konyang University Hospital
Daejeon, 302-718, South Korea
Chungnam National University Hospital
Daejeon, 35015, South Korea
Ewha Woman's University Seoul Hospital
Gangseo-gu, 7804, South Korea
Myongji Hospital
Goyang-si, 10475, South Korea
Chonnam National University Hospital
Gwangju, 61469, South Korea
Seoul National University Bundang Hospital
Gyeonggi-do, 13620, South Korea
Gachon University Gil Medical Center
Incheon, 21565, South Korea
The Catholic University of Korea, Incheon St. Mary's Hospital
Incheon, 403-720, South Korea
Chungnam National University Sejong Hospital
Sejong-si, 30099, South Korea
Korea University Anam Hospital
Seoul, 02841, South Korea
Seoul National University Hospital
Seoul, 03080, South Korea
VHS Medical Center
Seoul, 05368, South Korea
Asan Medical Center
Seoul, 05505, South Korea
Gangnam Severance Hospital, Yonsei University Health System
Seoul, 06273, South Korea
Seoul St.Mary s Hospital
Seoul, 06591, South Korea
Severance Hospital Yonsei University Health System
Seoul, 120-752, South Korea
Kyung Hee University Hospital
Seoul, 130 050, South Korea
Kyung Hee University Hospital at Gangdong
Seoul, 134-727, South Korea
Hanyang University Hospital
Seoul, 4763, South Korea
Korea University Guro Hospital
Seoul, 8308, South Korea
WonJu Severance Christian Hospital
Wŏnju, 220-701, South Korea
Pusan National University Yangsan Hospital
Yangsan, 50612, South Korea
Hosp. Gral. Univ. de Alicante
Alicante, 03010, Spain
Hosp. Del Mar
Barcelona, 08003, Spain
Hosp. de La Santa Creu I Sant Pau
Barcelona, 08025, Spain
Hosp Univ Vall D Hebron
Barcelona, 08035, Spain
Hosp Clinic de Barcelona
Barcelona, 08036, Spain
Hosp. Univ. Virgen de La Arrixaca
El Palmar, 30120, Spain
Hosp. de Cabuenes
Gijón, 33206, Spain
Hosp. Univ. Arnau de Vilanova de Lleida
Lleida, 25198, Spain
Hosp. Virgen de La Luz
Madrid, 28003, Spain
Hosp. Univ. de La Princesa
Madrid, 28006, Spain
Hosp. Univ. Ramon Y Cajal
Madrid, 28034, Spain
Hosp. Clinico San Carlos
Madrid, 28040, Spain
Hosp. Univ. 12 de Octubre
Madrid, 28041, Spain
Hosp. Univ. La Paz
Madrid, 28046, Spain
Hosp. Univ. Hm Monteprincipe
Madrid, 28660, Spain
Hosp. de Manises
Manises, 46940, Spain
Hosp Virgen de La Victoria
Málaga, 29010, Spain
Complejo Hosp. de Navarra
Pamplona, 31008, Spain
Hosp. Clinico Univ. de Santiago
Santiago de Compostela, 15706, Spain
Hosp. Univ. Joan Xxiii
Tarragona, 43007, Spain
Hosp. Clinico Univ. de Valencia 1
Valencia, 46010, Spain
Hosp. Gral. Univ. Valencia
Valencia, 46014, Spain
Hosp. Alvaro Cunqueiro
Vigo, 36312, Spain
Hosp. Univ. Miguel Servet
Zaragoza, 50009, Spain
Universitatsspital Basel
Basel, 4031, Switzerland
Universitätspital Bern, Universitätsklinik für Frauenheilkunde
Bern, 3010, Switzerland
Hopitaux Universitaires de Geneve - HUG
Geneva, 1211, Switzerland
Istituto Cardiocentro Ticino
Lugano, 6900, Switzerland
UniversitaetsSpital Zuerich
Zurich, 8091, Switzerland
Changhua Christian Hospital
Changhua, 50006, Taiwan
Kaohsiung Medical University Chung Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
E-DA Hospital
Kaohsiung City, 82445, Taiwan
Far Eastern Memorial Hospital
New Taipei City, 22060, Taiwan
Mackay Memorial Hospital
New Taipei City, 25160, Taiwan
China Medical University Hospital
Taichung, 404327, Taiwan
Chi Mei Medical Center Yong Kang
Tainan, 71004, Taiwan
National Taiwan University Hospital
Taipei, 10002, Taiwan
Cathay General Hospital
Taipei, 106, Taiwan
Taipei Medical University
Taipei, 110, Taiwan
Taipei Veterans General Hospital
Taipei, 11217, Taiwan
Cheng Hsin General Hospital
Taipei, 112, Taiwan
Tri-Service General Hospital
Taipei, 114202, Taiwan
Taipei Municipal Wanfang Hospital
Taipei, 116, Taiwan
Chang Gung Memorial Hospital- Linkou
Taoyuan, 33305, Taiwan
National Yang-Ming University Hospital
Yilan County, 260, Taiwan
Ramathibodi Hospital
Bangkok, 10400, Thailand
Siriraj Hospital
Bangkoknoi, 10700, Thailand
Maharaj Nakorn Chiang Mai Hospital
Chiang Mai, 50200, Thailand
Srinagarind Hospital
Nai Mueang Subdistrict Mueang, 40000, Thailand
King Chulalongkorn Memorial Hospital
Pathum Wan, 10330, Thailand
Afyon Kocatepe University Medical Faculty
Afyonkarahisar, 03200, Turkey (Türkiye)
Ankara Etlik Speciality Hospital
Ankara, 06010, Turkey (Türkiye)
Ankara University Medical Faculty
Ankara, 06100, Turkey (Türkiye)
Ankara Numune Research and Training Hospital
Ankara, 06800, Turkey (Türkiye)
Bursa Yuksek Ihtisas Training and Research Hospital
Bursa, 16330, Turkey (Türkiye)
Osmangazi University Medical Faculty
Eskişehir, 26480, Turkey (Türkiye)
Bezmi Alem Vakif University Medical Faculty Hospital
Istanbul, 34093, Turkey (Türkiye)
Marmara University Pendik Training Hospital
Istanbul, 34899, Turkey (Türkiye)
Dokuz Eylul University Medical Faculty
Izmir, 35340, Turkey (Türkiye)
Karabuk University Medical Faculty
Karabük, 06100, Turkey (Türkiye)
Erciyes University Medical Faculty
Kayseri, 38039, Turkey (Türkiye)
Kutahya Health Science University Evliya Celebi Research and Training Hospital
Kütahya, 43040, Turkey (Türkiye)
Mersin University Medical Faculty
Mersin, 33020, Turkey (Türkiye)
Ondokuz Mayis University
Samsun, 55139, Turkey (Türkiye)
Basingstoke And North Hampshire Hospital
Basingstoke, RG24 9NA, United Kingdom
Royal United Hospital
Bath, BA1 3NG, United Kingdom
Queen Elizabeth Hospital
Birmingham, B15 2WB, United Kingdom
Birmingham Heartlands Hospital
Birmingham, B9 5SS, United Kingdom
Blackpool Victoria Hospital
Blackpool, FY3 8NR, United Kingdom
Royal Bournemouth Hospital
Bournemouth, BH7 7DW, United Kingdom
University Hospital Bristol and Weston NHS trust
Bristol, BS1 3NU, United Kingdom
Dorset County Hospital
Dorchester, DT1 2JY, United Kingdom
Russels Hall Hospital
Dudley, DY1 2HQ, United Kingdom
Hairmyres Hospital
East Kilbride, G75 8RG, United Kingdom
Royal Infirmary of Edinburgh
Edinburgh, EH16 4SA, United Kingdom
Royal Devon and Exeter Hospital(Wonford)
Exeter, EX2 5DW, United Kingdom
Royal Free Hospital
Hampstead, NW3 2QG, United Kingdom
Harefield Hospital
Harefield, UB9 6JH, United Kingdom
West Middlesex University Hospital
Isleworth, TW7 6AF, United Kingdom
Kingston Hospital
Kingston upon Thames, KT2 7QB, United Kingdom
Leeds General Infirmary
Leeds, LS1 3EX, United Kingdom
Lincoln County Hospital
Lincoln, LN2 5QY, United Kingdom
Barts Hospital
London, EC1A 7BE, United Kingdom
Hammersmith Hospital
London, W12 0HS, United Kingdom
Altnagelvin Hospital
Londonderry, BT47 6SB, United Kingdom
North Manchester General Hospital
Manchester, M8 6RL, United Kingdom
James Cook University Hospital
Middlesbrough, TS4 3BW, United Kingdom
Freeman Hospital
Newcastle upon Tyne, NE7 7DN, United Kingdom
Peterborough City Hospital
Peterborough, PE3 9GZ, United Kingdom
Derriford Hospital
Plymouth, PL6 8DH, United Kingdom
Queen Alexandra Hospital
Portsmouth, PO6 3LY, United Kingdom
East Surrey Hospital
Redhill, RH1 5RH, United Kingdom
Lister Hospital
Stevenage, SG1 4AB, United Kingdom
Morriston Hospital
Swansea, SA6 6NL, United Kingdom
Musgrove Park Hospital
Taunton, TA1 5DA, United Kingdom
Torbay Hospital-Devon
Torquay, TQ2 7AA, United Kingdom
Sandwell and West Birmingham Hospitals NHS Trust-Sandwell Gene
West Bromwich, B71 4HJ, United Kingdom
Royal Albert Edward Infirmary
Wigan, WN1 2NN, United Kingdom
Yeovil District Hospital
Yeovil, BA214AT, United Kingdom
Bach Mai Hospital
Hanoi, 100000, Vietnam
Tam Anh General Hospital
Hanoi, 100000, Vietnam
103 Military Hospital
Hanoi, Vietnam
Hanoi Heart Hospital
Hanoi, Vietnam
Hanoi Medical University Hospital
Hanoi, Vietnam
People's Hospital 115
Ho Chi Minh City, 700000, Vietnam
Tam Anh Hospital
Ho Chi Minh City, 700000, Vietnam
Thong Nhat HOSPITAL
Ho Chi Minh City, 700000, Vietnam
Tam Duc Heart Hospital
Ho Chi Minh City, Vietnam
Related Publications (1)
Gibson CM, Bahit MC, Mehran R, Mehta SR, Lamee RA, Goto S, Weitz JI, Horrow J, Barnathan ES, Harrington RA, Mahaffey KW, Lam CSP, Pieper KS, Johnston SC, Hankey GJ, Plotnikov AN, Li D, Deng H, Steg PG; Librexia ACS Committees and Investigators.. Oral factor xia inhibitor milvexian after a recent acute coronary syndrome: Rationale and design of the phase 3 (Librexia ACS). Am Heart J. 2025 Jul;285:21-28. doi: 10.1016/j.ahj.2025.02.011. Epub 2025 Feb 20.
PMID: 39986336DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Janssen Research & Development, LLC Clinical Trial
Janssen Research & Development, LLC
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 23, 2023
First Posted
March 6, 2023
Study Start
April 7, 2023
Primary Completion
February 6, 2026
Study Completion
February 6, 2026
Last Updated
April 13, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
The data sharing policy of the Janssen Pharmaceutical Companies of Johnson \& Johnson is available at www.janssen.com/clinical-trials/transparency. As noted on this site, requests for access to the study data can be submitted through Yale Open Data Access (YODA) Project site at yoda.yale.edu