Phase III Acute Coronary Syndrome
APPRAISE-2
Apixaban for Prevention of Acute Ischemic Events - 2 A Phase 3, Randomized, Double-Blind, Evaluation of the Safety and Efficacy of Apixaban In Subjects With a Recent Acute Coronary Syndrome
2 other identifiers
interventional
7,484
39 countries
1004
Brief Summary
The purpose of this study is to determine if apixaban is superior to placebo for preventing cardiovascular death, non-fatal myocardial infarction, or ischemic stroke in subjects with a recent acute coronary syndrome
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Mar 2009
1004 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 28, 2009
CompletedFirst Posted
Study publicly available on registry
January 29, 2009
CompletedStudy Start
First participant enrolled
March 1, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2011
CompletedResults Posted
Study results publicly available
January 27, 2016
CompletedJanuary 27, 2016
December 1, 2015
2 years
January 28, 2009
December 18, 2015
December 18, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Event Rate of Cardiovascular Death, Myocardial Infarction, or Ischemic Stroke During the Intended Treatment Period - Randomized Participants
Event rate was percent of participants with an event of cardiovascular (CV) death, myocardial infarction (MI), or ischemic stroke (number of participants with event/number randomized) per 100 patient (100-pt) years. Study was terminated early and last patient, last visit was in Year 2. Only events confirmed by the adjudication committee were included in the analyses. CV death included deaths due to CV causes (eg, cardiogenic shock, heart failure, arrhythmia/sudden death, cardiac rupture, ischemic stroke, pulmonary embolism, venous/arterial thrombotic events) and other sudden deaths for which an alternative cause was not identified. Intended Treatment Period: the period that started on the day of randomization and ended at the efficacy cut-off date (cut-off date: the date all sites were informed that study drug should be discontinued for all participants, 18 November 2010).
Randomization (Day 1) to first event (CV death, MI, ischemic stroke), up to March 2011, approximately 2 years
Event Rate of Confirmed Major Bleeding Using Thrombolysis in Myocardial Infarction (TIMI) Criteria During the Treatment Period - Treated Participants
TIMI Major Bleed Criteria: Fatal bleeding, intracranial hemorrhage, and clinically overt bleeding with a hemoglobin (Hgb) drop of ≥ 5 grams per deciliter (g/dL), or ≥15% absolute decrease in hematocrit. To account for transfusions, Hgb measurements were adjusted for transfusions. A transfusion of 1 unit of blood was assumed to result in an increase by 1 g/dL in Hgb or 3% in hematocrit. Event rate was percent of participants with an event of Major Bleed as per TIMI (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. Treatment Period=events with onset from first dose to last dose plus 2 days.
From first dose to first occurrence of event (TIMI major bleeding) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years
Secondary Outcomes (10)
Event Rate of Unstable Angina (UA) During the Intended Treatment Period - Randomized Participants
Randomization (Day 1) to first event of UA, up to March 2011, approximately 2 years
Event Rate of Stroke During the Intended Treatment Period - Randomized Participants
Randomization (Day 1) to first event (stroke), up to March 2011, approximately 2 years
Event Rate of Myocardial Infarction (MI) During the Intended Treatment Period - Randomized Participants
Randomization (Day 1) to first event (MI), up to March 2011, approximately 2 years
Event Rate of Stent Thrombosis During the Intended Treatment Period - Randomized Participants
Randomization (Day 1) to first event (stent thrombosis), up to March 2011, approximately 2 years
Event Rate of Composite of Cardiovascular Death, Myocardial Infarction, Unstable Angina, or Ischemic Stroke During the Intended Treatment Period - Randomized Participants
Randomization (Day 1) to first event (CV death, MI, UA, Ischemic Stroke, up to March 2011, approximately 2 years
- +5 more secondary outcomes
Study Arms (2)
Apixaban
ACTIVE COMPARATORPlacebo
PLACEBO COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Acute coronary syndrome (ACS)
- Clinically stable
- Receiving standard of care for ACS
You may not qualify if:
- Severe hypertension
- Active bleeding or high risk for major bleeding
- Hemoglobin \< 9 g/dL
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Bristol-Myers Squibblead
- Pfizercollaborator
- Duke Clinical Research Institutecollaborator
Study Sites (1012)
Uab Medical Center
Birmingham, Alabama, 35294, United States
University Of Alabama At Birmingham
Birmingham, Alabama, 35294, United States
Heart Center Research, Llc
Huntsville, Alabama, 35801, United States
North Phoenix Heart Center
Phoenix, Arizona, 85020, United States
Sparks Regional Medical Center
Fort Smith, Arkansas, 72901, United States
Nea Baptist Clinic
Jonesboro, Arkansas, 72401, United States
Phase Care, Llc
Alameda, California, 94501, United States
Cardiology Consultants Of Orange County
Anaheim, California, 92801, United States
Beaver Medical Group
Banning, California, 92220, United States
Local Institution
Chula Vista, California, 91911, United States
Escondido Cardiology Associates, Inc.
Escondido, California, 92025, United States
William D. Bowden, D.O.
Healdsburg, California, 95448, United States
California Heart Specialists, Inc.
Huntington Beach, California, 92648, United States
Caring Clinical Research Corporation
Laguna Hills, California, 92653, United States
Eisenstein, Isaac
Lakewood, California, 90712, United States
Arvind J. Mehta, Md
Long Beach, California, 90806, United States
Local Institution
Los Alamitos, California, 90720, United States
Preciado Cardiology Incorporated
Los Angeles, California, 90033, United States
East Bay Physicians Medical Group
Oakland, California, 94609, United States
St. Joseph Heritage Medical Group
Orange, California, 92868, United States
A.R.I. Clinical Trials, Inc.
Redondo Beach, California, 90277, United States
Coastal Multi-Specialty Research
Santa Ana, California, 92704, United States
Radiant Research, Inc
Santa Rosa, California, 95405, United States
Harbbor-Ucla Medical Center
Torrance, California, 90509, United States
Rocky Mountain Cardiology
Boulder, Colorado, 80304, United States
South Denver Cardiology Associates Pc
Littleton, Colorado, 80120, United States
Drogue Medical, Llc
Wheat Ridge, Colorado, 80033, United States
Hartford Hospital
Hartford, Connecticut, 06102, United States
Alfieri Cardiology
Newark, Delaware, 19713, United States
Orlando Heart Specialists
Altamonte Springs, Florida, 32714, United States
Palm Beach Heart Institute, Llc
Atlantis, Florida, 33462, United States
Ronald L. Walsh, Do
Clearwater, Florida, 33756, United States
The Heart And Vascular Institute Of Florida
Clearwater, Florida, 33756, United States
Cardiovascular Specialist Of South Florida
Davie, Florida, 33324, United States
David E. Perloff, Md
Fort Lauderdale, Florida, 33316, United States
Nature Coast Clinical Research
Inverness, Florida, 34452, United States
Jacksonville Heart Center, Pa
Jacksonville, Florida, 32207, United States
Jacksonville Center For Clinical Research
Jacksonville, Florida, 32216, United States
East Coast Institute For Research
Jacksonville, Florida, 32223, United States
The Cardio Vascular Center P.A.
Lake Mary, Florida, 32746, United States
Alpha Medical Research, Llc
Melbourne, Florida, 32901, United States
Melbourne Internal Medicine Associates (Mima)
Melbourne, Florida, 32901, United States
Glenn J. Barquet, Md
Miami, Florida, 33133, United States
Miami Cardiology Clinical Research, L.L.C.
Miami, Florida, 33156, United States
Advanced Pharma Clinical Research
Miami, Florida, 33175, United States
Mount Sinai Medical Center
Miami Beach, Florida, 33140, United States
Mediquest Research Group Inc.
Ocala, Florida, 34471, United States
Ocala Research Institute, Inc
Ocala, Florida, 34471, United States
Florida Heart Group
Orlando, Florida, 32803, United States
Orlando Heart Center
Orlando, Florida, 32806, United States
Palm Beach Gardens Research Center Llc
Palm Beach Gardens, Florida, 33410, United States
Local Institution
Pembroke Pines, Florida, 33028, United States
Cardiology Consultants
Pensacola, Florida, 32501, United States
Advent Clinical Research Centers, Inc.
Pinellas Park, Florida, 33781, United States
Cardio-Pulmonary Associates
Plantation, Florida, 33317, United States
Avivo Clin Clinical Services
Port Orange, Florida, 32127, United States
St. Augustine Cardiology Associates
Saint Augustine, Florida, 32086, United States
Heartcare Research
Sarasota, Florida, 34232, United States
Dr Kiran C Patel Research Institute At Pepin Heart Hospital
Tampa, Florida, 33613, United States
Howard T. Tee, M.D., F.A.C.P., F.A.C.C.
Vero Beach, Florida, 32960, United States
Indian River Cardiovascular Associates, Inc
Vero Beach, Florida, 32960, United States
Cardiology Partners Clinical Research Institute
Wellington, Florida, 33449, United States
Cardiovascular Physicians Of North Atlanta
Atlanta, Georgia, 30342, United States
Medical College Of Georgia
Augusta, Georgia, 30912, United States
Columbus Cardiology Associates Pc
Columbus, Georgia, 31909, United States
Georgia Heart Specialists
Covington, Georgia, 30014, United States
Atlanta Institute For Medical Research, Inc
Decatur, Georgia, 30030, United States
In-Quest Medical Research, Llc
Duluth, Georgia, 30096, United States
Alta Pharmaceutical Research Center, Inc.
Dunwoody, Georgia, 30338, United States
North Georgia Medical Research
Ellijay, Georgia, 30540, United States
Northeast Georgia Heart Cntr, Pc
Gainesville, Georgia, 30501, United States
Mercer University School Of Medicine
Macon, Georgia, 31201, United States
Well Star Cardiovascular Medicine, Pc
Marietta, Georgia, 30060, United States
Southern Heart Research Institute, Llc
Riverdale, Georgia, 30274, United States
Memorial Hospital Of Carbondale
Carbondale, Illinois, 62901, United States
Northwestern University
Chicago, Illinois, 60611, United States
Rush University Medical Center
Chicago, Illinois, 60612, United States
University Of Chicago Hospitals
Chicago, Illinois, 60637, United States
Clinical Investigation Specialists, Inc
Gurnee, Illinois, 60031, United States
Gateway Cardiology. P.C
Jerseyville, Illinois, 62052, United States
Midwest Heart Foundation
Lombard, Illinois, 60148, United States
Local Institution
Moline, Illinois, 61265, United States
Illinois Heart & Lung Research
Normal, Illinois, 61761, United States
Heartcare Midwest
Peoria, Illinois, 61614, United States
Elkhart Clinic, Llc
Elkhart, Indiana, 46514, United States
St Margaret Mercy Healthcare Centers
Hammond, Indiana, 46320, United States
Krannertt Institute Of Cardiology
Indianapolis, Indiana, 46202, United States
R. L.Roudebush Va Medical Center
Indianapolis, Indiana, 46202, United States
The Care Group, Llc
Indianapolis, Indiana, 46260, United States
Medical Consultants, Pc
Muncie, Indiana, 47303, United States
Local Institution
Valparaiso, Indiana, 46383, United States
Mcfarland Clinic Pc
Ames, Iowa, 50010, United States
Iowa Heart Center
West Des Moines, Iowa, 50266, United States
Midwest Cardiology Associates , P.C.
Overland Park, Kansas, 66209, United States
Kentucky Heart & Vascular Physicians
Ashland, Kentucky, 41101, United States
Local Institution
Hazard, Kentucky, 41701, United States
Cardiovascular Associates, Psc
Louisville, Kentucky, 40205, United States
Research Integrity, Llc
Owensboro, Kentucky, 42303, United States
Alexandria Cardiology Clinic
Alexandria, Louisiana, 71301, United States
Clinical Research Network
Alexandria, Louisiana, 71301, United States
Tulane University Hospital And Clinic
New Orleans, Louisiana, 70112, United States
Overton Brooks V.A.M.C.
Shreveport, Louisiana, 71101, United States
Louisiana State University Health Sciences Center-Shreveport
Shreveport, Louisiana, 71103, United States
Louisiana Heart Center
Slidell, Louisiana, 70458, United States
Local Institution
Annapolis, Maryland, 21401, United States
Delmarva Heart Research Foundation
Salisbury, Maryland, 21804, United States
Peninsula Cardiology Associates, P.A.
Salisbury, Maryland, 21804, United States
Endeavor Medical Research, Plc
Alpena, Michigan, 49707, United States
Henry Ford Hospital
Detroit, Michigan, 48202, United States
Local Institution
Detroit, Michigan, 48236, United States
Genesys Regional Medical Center
Grand Blanc, Michigan, 48439, United States
Thoracic And Cardiovascular Healthcare Foundation
Lansing, Michigan, 48910, United States
Local Institution
Mount Pleasant, Michigan, 48858, United States
Covenant Medical Center, Inc
Saginaw, Michigan, 48602, United States
Great Lakes Heart & Vascular Institute, Pc
Saint Joseph, Michigan, 49085, United States
William Beaumont Hospital-Troy
Troy, Michigan, 48098, United States
Hennepin County Medical Center
Minneapolis, Minnesota, 55415, United States
Va Medical Center
Minneapolis, Minnesota, 55417, United States
University Of Minnesota, Medical School
Minneapolis, Minnesota, 55455, United States
St Cloud Hospital
Saint Cloud, Minnesota, 56303, United States
University Of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
Local Institution
Jackson, Mississippi, 49201, United States
Missouri Cardiovascular Specialists
Columbia, Missouri, 65201, United States
Washington University School Of Medicine
St Louis, Missouri, 63110, United States
Gateway Cardiology, P.C.
St Louis, Missouri, 63128, United States
Bryanlgh Heart Institute
Lincoln, Nebraska, 68506, United States
Heart Consultants
Omaha, Nebraska, 68114, United States
Alegent Health Clinic Heart & Vascular Specialists
Omaha, Nebraska, 68124, United States
Local Institution
Brick, New Jersey, 08723, United States
Central Jersey Medical Research Center
Elizabeth, New Jersey, 07202, United States
Hamilton Cardiology Associates
Hamilton, New Jersey, 08690, United States
Local Institution
Linden, New Jersey, 07036, United States
The Valley Hospital
Ridgewood, New Jersey, 07450, United States
Central New Jersey Cardiology
South Plainfield, New Jersey, 07080, United States
New York Methodist Hospital
Brooklyn, New York, 11215, United States
Buffalo General Hospital
Buffalo, New York, 14203, United States
Dr. Michael Sacher
Massapequa, New York, 11758, United States
Hudson Valley Heart Center
Poughkeepsie, New York, 12601, United States
Asheville Cardiology Associates
Asheville, North Carolina, 28803, United States
The University Of North Carolina At Chapel Hill
Chapel Hill, North Carolina, 27599, United States
Duke University Medical Center
Durham, North Carolina, 27710, United States
East Carolina Heart Institute At East Carolina University
Greenville, North Carolina, 27834, United States
Wake Med Heart Center
Raleigh, North Carolina, 27610, United States
Wilmington Medical Research
Wilmington, North Carolina, 28401, United States
Azalea Research Center
Wilmington, North Carolina, 28403, United States
Local Institution
Fargo, North Dakota, 58122, United States
Otfried N. Niedermaier, Md
Akron, Ohio, 44304, United States
City Cardiology Associates
Barberton, Ohio, 44203, United States
Cincinnati Veterans Affairs Medical Center
Cincinnati, Ohio, 45220, United States
Fairfield Cardiac Cath Lab, Llc
Fairfield, Ohio, 45014, United States
Genoa Medical Center
Genoa, Ohio, 43430, United States
Middletown Cardiovascular Associates
Middletown, Ohio, 45044, United States
Toledo Cardiology Consultants
Toledo, Ohio, 43608, United States
Local Institution
Youngstown, Ohio, 44501, United States
Cardiology Associates Of Southeastern Ohio
Zanesville, Ohio, 43701, United States
Blue Stem Cardiology
Bartlesville, Oklahoma, 74006, United States
Cor Clinical Research, Llc
Oklahoma City, Oklahoma, 73103, United States
University Of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
Oklahoma Cardiovascular Associates
Oklahoma City, Oklahoma, 73109, United States
St. Charles Health System, Inc.
Bend, Oregon, 97701, United States
Portland Preventive Cardiology, L.L.C.
Portland, Oregon, 97225, United States
Blair Medical Associates, Inc.
Altoona, Pennsylvania, 16602, United States
St. Lukes Cardiology Associates
Bethlehem, Pennsylvania, 18018, United States
Consultants In Cardiovascular Diseases, Inc.
Erie, Pennsylvania, 16502, United States
Hamot Medical Center
Erie, Pennsylvania, 16507, United States
Richard M. Kastelic M.D. & Associates, P.C.
Johnstown, Pennsylvania, 15905, United States
The Heart Group
Lancaster, Pennsylvania, 17603, United States
Drexel University College Of Medicine
Philadelphia, Pennsylvania, 19102, United States
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104, United States
Pennsylvania Cardiology Associates
Philadelphia, Pennsylvania, 19106, United States
Va Pittsburgh Healthcare System
Pittsburgh, Pennsylvania, 15240, United States
Pottstown Medical Specialists, Inc
Pottstown, Pennsylvania, 19464, United States
Local Institution
Scranton, Pennsylvania, 18508, United States
Buxmont Cardiology Associates, Pc
Sellersville, Pennsylvania, 18960, United States
Moffit Heart & Vascular Group
Wormleysburg, Pennsylvania, 17043, United States
The Miriam Hospital
Providence, Rhode Island, 02906, United States
Anmed Health
Anderson, South Carolina, 29621, United States
Carl Wilson Sofley, Jr., Md
Anderson, South Carolina, 29621, United States
Lowcountry Medical Group
Beaufort, South Carolina, 29906, United States
Columbia Cardiology
Columbia, South Carolina, 29204, United States
Cardiology Assoicates, Pc/Black Hills Clinical Research Ctr
Rapid City, South Dakota, 57701, United States
North Central Heart Institute
Sioux Falls, South Dakota, 57108, United States
The Chattanooga Heart Institute
Chattanooga, Tennessee, 37404, United States
The Stern Cardiovascular Center, Pa
Germantown, Tennessee, 38138, United States
Research Associates Of Jackson
Jackson, Tennessee, 38301, United States
Mountain State Health Alliance
Johnson City, Tennessee, 37604, United States
Knoxville Heart Group
Knoxville, Tennessee, 37916, United States
Access Clinical Trials
Nashville, Tennessee, 37203, United States
Parkway Cardiology Associates, Pc
Oak Ridge, Tennessee, 37830, United States
Amarillo Heart Clinical Research Institute Inc.
Amarillo, Texas, 79106, United States
Dallas Va Medical Center
Dallas, Texas, 75216, United States
Cardiovascular Research Institute Of Dallas
Dallas, Texas, 75231, United States
Heart Consultants Of North Texas
Dallas, Texas, 75231, United States
Texas Health Research & Education Institute
Fort Worth, Texas, 76104, United States
T&R Clinic
Fort Worth, Texas, 76117, United States
Med Tech, Inc.
Houston, Texas, 77024, United States
Methodist Debakey Heart & Vascular Center
Houston, Texas, 77030, United States
Centex Research, Pineloch Medical Clinic
Houston, Texas, 77062, United States
Heart Care Center
Houston, Texas, 77070, United States
Northwest Houston Cardiology, Pa
Houston, Texas, 77070, United States
Texas Cardiac Center
Lubbock, Texas, 79410, United States
Central Cardiovascular Institute Of San Antonio
San Antonio, Texas, 78201, United States
Jose A. Perez, M.D.
San Antonio, Texas, 78201, United States
S.A.M. Clinical Research Center
San Antonio, Texas, 78229, United States
Sugarland Cardiology Associates
Sugarland, Texas, 77479, United States
Scott&White Memorial Hospital
Temple, Texas, 76508, United States
Northwest Heart Center
Tomball, Texas, 77375, United States
Tyler Cardiovascular Consultants
Tyler, Texas, 75701, United States
Utah Cardiology P.C
Layton, Utah, 84041, United States
Bermisa Family Practice & Research Center
Chesapeake, Virginia, 23321, United States
Zakhary, Bosh
Danville, Virginia, 24541, United States
Heart Care Associates P.C.
Hopewell, Virginia, 23860, United States
The Cardiology Group Centra.
Lynchburg, Virginia, 24501, United States
Virginia Cardiolovascular Associates
Manassas, Virginia, 20109, United States
Local Institution
Midlothian, Virginia, 23114, United States
Sendara Cardiovasular Research Institute
Norfolk, Virginia, 23507, United States
Virgina Commonwealth Universitymedical Center
Richmond, Virginia, 23298, United States
Inland Cardiology Associates
Spokane, Washington, 99204, United States
Franciscan Research Center
Tacoma, Washington, 98405, United States
Dean And St. Mary'S Outpatient Center
Madison, Wisconsin, 53715, United States
Wheaton Franciscan Healthcare St. Joseph
Milwaukee, Wisconsin, 53210, United States
Local Institution
Berazategui, Buenos Aires, B1884KZB, Argentina
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Buenos Aires, Buenos Aires, 1039, Argentina
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Buenos Aires, Buenos Aires, 1119, Argentina
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Buenos Aires, Buenos Aires, 1122, Argentina
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Buenos Aires, Buenos Aires, 1280, Argentina
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Buenos Aires, Buenos Aires, 1428, Argentina
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Capital Federal, Buenos Aires, 1155, Argentina
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Ciudad Autonoma Buenos Aires, Buenos Aires, 1180, Argentina
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Ciudad Autonoma de Beunos Aire, Buenos Aires, 1431, Argentina
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Coronel Suárez, Buenos Aires, 7540, Argentina
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Gaba, Buenos Aires, 1437, Argentina
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Haedo, Buenos Aires, B1706AJU, Argentina
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Junín, Buenos Aires, 6000, Argentina
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La Plata, Buenos Aires, B1902COS, Argentina
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Lanús Oeste, Buenos Aires, 1824, Argentina
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Morón, Buenos Aires, 1708, Argentina
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Quilmes, Buenos Aires, B1878DKF, Argentina
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Ramos Mejía, Buenos Aires, B1704ETD, Argentina
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San Isidro, Buenos Aires, 1642, Argentina
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San Martín, Buenos Aires, B1650CSQ, Argentina
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Resistencia, Chaco Province, 3500, Argentina
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Corrientes, Corrientes Province, 3400, Argentina
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Corrientes Capital, Corrientes Province, 3400, Argentina
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Córdoba, Córdoba Province, 5000, Argentina
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Córdoba, Córdoba Province, 5002, Argentina
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Córdoba, Córdoba Province, 5006, Argentina
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Córdoba, Córdoba Province, X5004CDT, Argentina
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Villa Cabrera, Córdoba Province, 5009, Argentina
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Villa Carlos Paz, Córdoba Province, 5152, Argentina
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Villa María, Córdoba Province, 5900, Argentina
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San Salvador de Jujuy, Jujuy Province, Y4600ABF, Argentina
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Capital, Mendoza Province, 5500, Argentina
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Posadas, Misiones Province, 3300, Argentina
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Cipolletti, Río Negro Province, 8324, Argentina
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Salta, Salta Province, A4400ANG, Argentina
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San Luis, San Luis Province, D5702JRS, Argentina
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Rosario, Santa Fe Province, 2000, Argentina
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Rosario, Santa Fe Province, 2002, Argentina
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Santa Fe, Santa Fe Province, 3000, Argentina
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Santa Fe, Santa Fe Province, S3000AZG, Argentina
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San Miguel de Tucumán, Tucumán Province, 4000, Argentina
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San Miguel de Tucumán, Tucumán Province, T4000ICL, Argentina
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Bruce, Australian Capital Territory, 2617, Australia
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Broken Hill, New South Wales, 2880, Australia
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Kogarah, New South Wales, 2217, Australia
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Lismore, New South Wales, 2480, Australia
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Cairns, Queensland, 4870, Australia
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Herston, Queensland, 4031, Australia
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Milton, Queensland, 4064, Australia
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Ashford, South Australia, 5035, Australia
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Elizabeth Vale, South Australia, 5112, Australia
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Woodville, South Australia, 5011, Australia
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Fitzroy, Victoria, 3065, Australia
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Geelong, Victoria, 3220, Australia
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Richmond, Victoria, 3121, Australia
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Feldkirch, 6800, Austria
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Graz, 8036, Austria
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Linz, 4020, Austria
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Oberpullendorf, 7350, Austria
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Vienna, 1030, Austria
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Vienna, 1090, Austria
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Vienna, 1160, Austria
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Vienna, 1220, Austria
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Antwerp, Antwerpen, 2060, Belgium
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Aalst, 9300, Belgium
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Anderlecht, 1070, Belgium
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Bonheiden, 2820, Belgium
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Brasschaat, 2930, Belgium
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Bruges, 8000, Belgium
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Ghent, 9000, Belgium
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Huy, 4500, Belgium
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Ieper, 8900, Belgium
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Mechelen, 2800, Belgium
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Mol, 2400, Belgium
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Yvoir, 5530, Belgium
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Maceió, Alagoas, 57051, Brazil
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Sobral, Ceará, 62041, Brazil
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Salvador, Estado de Bahia, 40144, Brazil
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Salvador, Estado de Bahia, 40323, Brazil
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Salvador, Estado de Bahia, 41148, Brazil
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Salvador, Estado de Bahia, 41810, Brazil
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Brasília, Federal District, 70335, Brazil
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Brasília, Federal District, 70390, Brazil
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Brasília, Federal District, 70658, Brazil
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Brasília, Federal District, 72115, Brazil
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Goiânia, Goiás, 74809, Brazil
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Goiânia, Goiás, 74823, Brazil
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Juiz de Fora, Mato Grosso, 36021, Brazil
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Belo Horizonte, Minas Gerais, 30110, Brazil
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Belo Horzonte, Minas Gerais, 30150, Brazil
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Uberlândia, Minas Gerais, 384000-368, Brazil
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Uberlândia, Minas Gerais, 38400, Brazil
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Curitiba, Paraná, 80010, Brazil
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Curitiba, Paraná, 80320, Brazil
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Curitiba, Paraná, 80730, Brazil
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Londrina, Paraná, 86010, Brazil
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Belém, Pará, 66087, Brazil
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Recife, Pernambuco, 50100, Brazil
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Rio de Janeiro, Rio de Janeiro, 22031, Brazil
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Rio de Janeiro, Rio de Janeiro, 22240, Brazil
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Rio de Janeiro, Rio de Janeiro, 22261, Brazil
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Rio Janeiro, Rio de Janeiro, 22280, Brazil
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Natal, Rio Grande do Norte, 59020, Brazil
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Passo Fundo, Rio Grande do Sul, 99010, Brazil
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Porto Alegre, Rio Grande do Sul, 90020, Brazil
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Porto Alegre, Rio Grande do Sul, 90035, Brazil
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Porto Alegre, Rio Grande do Sul, 90110, Brazil
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Porto Alegre, Rio Grande do Sul, 90610, Brazil
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Porto Alegre, Rio Grande do Sul, 90620, Brazil
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Porto Alegre, Rio Grande do Sul, 91350, Brazil
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Blumenau, Santa Catarina, 89010, Brazil
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São José, Santa Catarina, 88103, Brazil
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Campinas, São Paulo, 13059, Brazil
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Limeira, São Paulo, 13480, Brazil
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Marília, São Paulo, 17515, Brazil
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Marília, São Paulo, 17519, Brazil
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Santo André, São Paulo, 09020, Brazil
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Santo André, São Paulo, 09190, Brazil
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São Caetano do Sul, São Paulo, 09540, Brazil
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São José do Rio Preto, São Paulo, 15015, Brazil
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São José do Rio Preto, São Paulo, 15090, Brazil
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São Paulo, São Paulo, 01323, Brazil
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São Paulo, São Paulo, 01506, Brazil
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São Paulo, São Paulo, 02276, Brazil
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São Paulo, São Paulo, 04012, Brazil
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São Paulo, São Paulo, 04023, Brazil
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São Paulo, São Paulo, 05403, Brazil
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São Paulo, São Paulo, 05508, Brazil
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Burgas, 8000, Bulgaria
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Dimitrovgrad, 6400, Bulgaria
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Pazardzhik, 4400, Bulgaria
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Pleven, 5800, Bulgaria
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Plovdiv, 4000, Bulgaria
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Plovdiv, 4002, Bulgaria
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Sofia, 1142, Bulgaria
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Sofia, 1202, Bulgaria
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Sofia, 1233, Bulgaria
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Sofia, 1309, Bulgaria
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Sofia, 1407, Bulgaria
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Sofia, 1431, Bulgaria
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Sofia, 1527, Bulgaria
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Sofia, 1606, Bulgaria
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Sofia, 1618, Bulgaria
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Stara Zagora, 6003, Bulgaria
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Varna, 9010, Bulgaria
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Edmonton, Alberta, T5H 3V9, Canada
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Edmonton, Alberta, T6G 2B7, Canada
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Edmonton, Alberta, T6K 4C1, Canada
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New Westminster, British Columbia, V3L 3W5, Canada
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Penticton, British Columbia, V2A 3G6, Canada
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Victoria, British Columbia, V8R 4R2, Canada
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Winnipeg, Manitoba, R3K 0Y8, Canada
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St. John's, Newfoundland and Labrador, A1B 3V6, Canada
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Halifax, Nova Scotia, B3H 3A7, Canada
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Sydney, Nova Scotia, B1P 1P3, Canada
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Cambridge, Ontario, N1R 6V6, Canada
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Cambridge, Ontario, N1R 7R1, Canada
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Greater Sudbury, Ontario, P3C 5K7, Canada
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Greater Sudbury, Ontario, P3E 2N8, Canada
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Greater Sudbury, Ontario, P3E 3B8, Canada
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Grimsby, Ontario, L3M 1P3, Canada
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Kitchener, Ontario, N2M 1B2, Canada
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London, Ontario, N6A 5A5, Canada
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Oshawa, Ontario, L1H 1B9, Canada
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Oshawa, Ontario, L1H 7K4, Canada
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Oshawa, Ontario, L1J2K1, Canada
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Parry Sound, Ontario, P2A 3A4, Canada
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Sarnia, Ontario, N7T 4R9, Canada
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Scarborough Village, Ontario, M1E 4B9, Canada
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Scarborough Village, Ontario, M1P 2T7, Canada
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Toronto, Ontario, M4C 3E7, Canada
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Toronto, Ontario, M5B 1W8, Canada
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Toronto, Ontario, M5G 2C4, Canada
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Windsor, Ontario, N8X 1L9, Canada
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Chiccutimi, Quebec, G7H 5H6, Canada
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Lévis, Quebec, G6V 3Z1, Canada
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Montreal, Quebec, H3A 1A1, Canada
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Saint-Charles-Borromée, Quebec, J6E 6J2, Canada
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Saint-Jérôme, Quebec, J7Z 5T3, Canada
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Sorel-Tracy, Quebec, J3P1N5, Canada
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St-Foy, Quebec, G1V 4G5, Canada
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Terrebonne, Quebec, J6V 2H2, Canada
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Osorno, Los Lagos Region, 5311089, Chile
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Punta Arenas, Magallanes Antartica, 6212296, Chile
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Temuco, Región de la Araucanía, 4781176, Chile
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Viña del Mar, Región de Valparaíso, 2570017, Chile
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Concepción, Región del Biobío, 4070038, Chile
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Talcahuano, Región del Biobío, 4270918, Chile
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Santiago, Santiago Metropolitan, 6510031, Chile
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Santiago, Santiago Metropolitan, 7650018, Chile
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Santiago, Santiago Metropolitan, 8053095, Chile
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Santiago, Santiago Metropolitan, 8380000, Chile
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Santiago, Santiago Metropolitan, Chile
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Port Montt, Chile
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Beijing, Beijing Municipality, 100020, China
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Beijing, Beijing Municipality, 100029, China
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Beijing, Beijing Municipality, 100034, China
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Beijing, Beijing Municipality, 100038, China
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Beijing, Beijing Municipality, 100044, China
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Beijing, Beijing Municipality, 100088, China
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Beijing, Beijing Municipality, 100176, China
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Beijing, Beijing Municipality, 100730, China
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Chongqing, Chongqing Municipality, 400042, China
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Lanzhou, Gansu, 730030, China
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Guangzhou, Guangdong, 510010, China
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Guangzhou, Guangdong, 510080, China
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Guangzhou, Guangdong, 510120, China
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Guangzhou, Guangdong, 510180, China
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Nanning, Guangxi, 530021, China
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Shijiazhuang, Hebei, 710061, China
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Harbin, Heilongjiang, 150001, China
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Wuhan, Hubei, 430060, China
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Changsha, Hunan, 410005, China
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Nanjing, Jiangsu, 210008, China
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Nanjing, Jiangsu, 210009, China
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Nanjing, Jiangsu, 210029, China
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Suzhou, Jiangsu, 215004, China
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Suzhou, Jiangsu, 215006, China
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Nanchang, Jiangxi, 330006, China
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Changchun, Jilin, 130021, China
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Changchun, Jilin, 130041, China
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Dalian, Liaoning, 116023, China
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Shenyang, Liaoning, 110001, China
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Shenyang, Liaoning, 110004, China
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Shenyang, Liaoning, 110016, China
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Jinan, Shandong, 250012, China
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Beijing, Shanghai Municipality, 100037, China
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Shanghai, Shanghai Municipality, 200003, China
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Shanghai, Shanghai Municipality, 200065, China
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Shanghai, Shanghai Municipality, 200072, China
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Chengdu, Sichuan, 610041, China
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Chongqing, Sichuan, 400010, China
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Kunming, Yunnan, 650101, China
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Hangzhou, Zhejiang, 310009, China
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Hangzhou, Zhejiang, 310016, China
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Xi'an, 710061, China
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Bogotá, Cundinamaral, Colombia
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Cartagena, Departamento de Bolívar, Colombia
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Cali, Valle del Cauca Department, Colombia
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Barranquilla, Colombia
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Bogotá, Colombia
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Floridablanca, Colombia
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Manizales, Colombia
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Medellín, Colombia
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Brno, 625 00, Czechia
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Hradec Králové, 500 05, Czechia
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Liberec, 460 63, Czechia
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Nový Jičín, 741 01, Czechia
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Olomouc, 77520, Czechia
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Ostrava, 728 80, Czechia
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Prague, 100 34, Czechia
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Rakovník, 269 29, Czechia
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Ústí nad Orlicí, 562 18, Czechia
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Arhus C, 8000, Denmark
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Copenhagen, 2100, Denmark
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Copenhagen, 2300, Denmark
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Copenhagen, 2400, Denmark
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Esbjerg, 6700, Denmark
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Haderslev, 6100, Denmark
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Hellerup, 2900, Denmark
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Hillerød, 3400, Denmark
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Hvidovre, 2650, Denmark
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Næstved, 4700, Denmark
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Silkeborg, 8600, Denmark
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Slagelse, 4200, Denmark
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Espoo, 02740, Finland
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Helsinki, 00029, Finland
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Rovaniemi, 96101, Finland
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Tampere, 33520, Finland
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Albi, 81013, France
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Amiens, 80054, France
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Avignon, 84082, France
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Cholet, 49325, France
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Lagny-sur-Marne, 77405, France
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Langres, 52206, France
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Montpellier, 34000, France
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Paris, 76561, France
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Pau Universite Cedex, 64046, France
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Strasbourg, 67091, France
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Toulouse, 31076, France
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Bad Berka, 99437, Germany
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Bad Nauheim, 61231, Germany
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Berlin, 12351, Germany
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Berlin, 12559, Germany
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Berlin, 13509, Germany
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Berlin, 13585, Germany
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Bernau, 16321, Germany
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Bonn, 53105, Germany
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Bonn, 53115, Germany
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Chemnitz, 09111, Germany
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Coswig, 06869, Germany
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Cottbus, 03048, Germany
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Dachau, 85221, Germany
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Essen, 45122, Germany
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Flensburg, 24939, Germany
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Halle, 06120, Germany
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Hamburg, 20099, Germany
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Hamburg, 21075, Germany
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Hamburg, 22763, Germany
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Hoyerswerda, 02977, Germany
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Jena, 07747, Germany
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Leverkusen, 51375, Germany
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Limburg, 65549, Germany
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Lübeck, 23538, Germany
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Mainz, 55131, Germany
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Münster, 48149, Germany
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Neuss, 41464, Germany
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Paderborn, 33098, Germany
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Pirna, 01796, Germany
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Regensburg, 93053, Germany
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Rostock, 18057, Germany
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Wesel, 46483, Germany
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Baja, 6500, Hungary
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Balatonfüred, 8230, Hungary
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Budapest, 1027, Hungary
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Budapest, 1032, Hungary
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Budapest, 1041, Hungary
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Budapest, 1085, Hungary
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Budapest, 1096, Hungary
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Budapest, 1097, Hungary
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Budapest, 1106, Hungary
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Budapest, 1145, Hungary
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Budpest, 1122, Hungary
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Cegléd, 2700, Hungary
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Debrecen, 4032, Hungary
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Dunaújváros, 2400, Hungary
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Hódmezővásárhely, 6800, Hungary
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Kecskemét, 6000, Hungary
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Miskolc, 3526, Hungary
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Miskolc, 3529, Hungary
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Szekszárd, 7100, Hungary
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Szentes, 6600, Hungary
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Székesfehérvár, 8000, Hungary
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Szombathely, 9700, Hungary
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Zalaegerszeg, 8900, Hungary
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Hyderabad, Andhra Pradesh, 500-012, India
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Hyderabad, Andhra Pradesh, 500063, India
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Vijayawada, Andhra Pradesh, 520008, India
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Ahmedabad, Gujarat, 380006, India
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Ahmedabad, Gujarat, 380014, India
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Ahmedabad, Gujarat, 380015, India
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Vadodara, Gujarat, 390007, India
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Gurgaon, Haryana, 122001, India
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Bangalore, Karnataka, 560 099, India
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Bangalore, Karnataka, 560054, India
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Mysore, Karnataka, 570020, India
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Shivamogga, Karnataka, 577201, India
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Indore, Madhya Pradesh, 452008, India
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Mumbai, Maharashtra, 400007, India
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Mumbai, Maharashtra, 400050, India
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Nagpur, Maharashtra, 440010, India
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Nagpur, Maharashtra, 440012, India
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Nagpur, Maharashtra, 440033, India
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Pune, Maharashtra, 411001, India
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Pune, Maharashtra, 411004, India
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Jalandhar, Punjab, 144008, India
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Jaipur, Rajasthan, 302001, India
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Jaipur, Rajasthan, 302004, India
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Jaipur, Rajasthan, 302017, India
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Chennai, Tamil Nadu, 600081, India
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Coimbatore, Tamil Nadu, 641037, India
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Lucknow, Uttar Pradesh, 226003, India
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Bangalore, Karnataka, 560034, India
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Bikaner, 334001, India
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Mangalore, 575003, India
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New Delhi, 110025, India
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New Delhi, 110060, India
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Pune, 411004, India
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Afula, 18101, Israel
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Ashkelon, 78306, Israel
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Hadera, 38100, Israel
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Haifa, 31048, Israel
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Haifa, 31096, Israel
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Haifa, 34362, Israel
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Jerusalem, 91004, Israel
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Jerusalem, 91031, Israel
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Jerusalem, 91120, Israel
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Jerusalem, 91240, Israel
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Kfar Saba, 44281, Israel
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Nahariya, 22100, Israel
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Nazareth, 16000, Israel
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Nazareth, 16100, Israel
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Petah Tikva, 49100, Israel
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Rehovot, 76100, Israel
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Safed, 13100, Israel
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Tel Aviv, 64239, Israel
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Tiberias, 15208, Israel
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Ascoli Piceno, 63100, Italy
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Bergamo, 24128, Italy
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Chieti, 66013, Italy
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Foggia, 71100, Italy
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Gravedona (Co), 22015, Italy
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Grosseto, 58100, Italy
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Massa, 54100, Italy
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Milan, 20138, Italy
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Milan, 20132, Italy
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Naples, 80131, Italy
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Novara, 28100, Italy
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Pavia, 27100, Italy
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Perugia, 06126, Italy
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Roma, 00184, Italy
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San Daniele Del Friuli (Udine), 33038, Italy
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Saronno (Va), 21047, Italy
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Verona, 37126, Italy
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Nagoya, Aichi-ken, 4538511, Japan
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Nagoya, Aichi-ken, 455-8530, Japan
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Nagoya, Aichi-ken, 4600001, Japan
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Nagoya, Aichi-ken, 4668650, Japan
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Seto-Shi, Aichi-ken, 4898642, Japan
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Matsudo, Chiba, 2710077, Japan
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Fukuoka, Fukuoka, 814-0180, Japan
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Kasuga, Fukuoka, 816-0864, Japan
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Kurume, Fukuoka, 830-8577, Japan
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Gifu, Gifu, 5008513, Japan
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Gifu, Gifu, 5008727, Japan
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Ogaki-Shi, Gifu, 503-8502, Japan
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Kure, Hiroshima, 737-0023, Japan
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Obihiro, Hokkaido, 0808518, Japan
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Sapporo, Hokkaido, 0630005, Japan
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Kasama, Ibaraki, 309-1793, Japan
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Tsuchiura-Shi, Ibaraki, 300-0053, Japan
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Tsukuba, Ibaraki, 3058558, Japan
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Kanazawa, Ishikawa-ken, 9200007, Japan
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Kanoya, Kagoshima-ken, 8930015, Japan
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Yokohama, Kanagawa, 232-0024, Japan
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Yokohama, Kanagawa, 234-8503, Japan
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Yokohama Sakae-Ku, Kanagawa, 247-8581, Japan
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Yokosuka, Kanagawa, 2388567, Japan
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Kochi, Kochi, 7808522, Japan
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Kumamoto, Kumamoto, 8600008, Japan
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Kumamoto, Kumamoto, 8608556, Japan
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Kumamoto, Kumamoto, 861-4193, Japan
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Kumamoto, Kumamoto, 862-0965, Japan
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Kyoto, Kyoto, 6158087, Japan
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Ueda, Nagano, 386-8610, Japan
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Beppu, Oita Prefecture, 874-0011, Japan
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Ōita, Oita Prefecture, 870-0263, Japan
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Osaka, Osaka, 558-8558, Japan
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Sakai, Osaka, 591-8025, Japan
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Saga, Saga-ken, 840-8571, Japan
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Ureshino, Saga-ken, 8430393, Japan
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Ageo, Saitama, 362-8588, Japan
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Koshigaya, Saitama, 3438555, Japan
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Toda, Saitama, 3350023, Japan
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Komatsushimachō, Tokushima, 7738502, Japan
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Chiyoda-Ku, Tokyo, 101-8643, Japan
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Chuo-Ku, Tokyo, 1048560, Japan
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Hachiōji, Tokyo, 1930998, Japan
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Meguro City, Tokyo, 153-8515, Japan
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Meguro-Ku, Tokyo, 1528902, Japan
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Tokyo, Tokyo, 1600023, Japan
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Iwakuni, Yamaguchi, 7408510, Japan
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Ube, Yamaguchi, 7558505, Japan
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Aguascalientes, Aguascalientes, 20127, Mexico
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Aguascalientes, Aguascalientes, 20230, Mexico
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Cabo San Lucas, Baja Californa Sur, 23410, Mexico
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Chihuahua City, Chihuahua, 31203, Mexico
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Monclova, Coahuila, 25750, Mexico
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Durango, Durango, 34270, Mexico
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Tijuana, Estado de Baja California, 22500, Mexico
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Acapulco de Juárez, Guerrero, 39570, Mexico
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Acapulco de Juárez, Guerrero, 39670, Mexico
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Pachuca, Hidalgo, 42070, Mexico
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Guadalajara, Jalisco, 44200, Mexico
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Guadalajara, Jalisco, 44210, Mexico
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Guadalajara, Jalisco, 44280, Mexico
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Zapopan, Jalisco, 45040, Mexico
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Monterrey, Nuevo León, 64000, Mexico
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Monterrey, Nuevo León, 64060, Mexico
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Monterrey, Nuevo León, 64460, Mexico
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Monterrey, Nuevo León, 64550, Mexico
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Monterrey, Nuevo León, 64710, Mexico
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Querétaro City, Querétaro, 76000, Mexico
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San Luis Potosí City, San Luis Potosí, 78240, Mexico
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Culiacán, Sinaloa, 80020, Mexico
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Metepec, State of Mexico, 52140, Mexico
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Tlalnepantla, State of Mexico, 54030, Mexico
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Veracruz, Veracruz, 91700, Mexico
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Xalapa, Veracruz, 91190, Mexico
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Alkmaar, 1815 JD, Netherlands
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Almere Stad, 1315 RA, Netherlands
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Amsterdam, 1091 AC, Netherlands
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Beverwijk, 1942 LE, Netherlands
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Boxmeer, 5831 HA, Netherlands
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Dirksland, 3247 BW, Netherlands
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Ede, 6916 RP, Netherlands
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Goes, 4462 RA, Netherlands
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Gouda, 2803 HH, Netherlands
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Heerlen, 6419 PC, Netherlands
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Hilversum, 1213 XZ, Netherlands
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Maastrict, 6229 HX, Netherlands
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Meppel, 7943KA, Netherlands
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Purmerend, 1441 RN, Netherlands
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Sneek, 8601 ZK, Netherlands
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The Hague, 2597 AX, Netherlands
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Veldhoven, 5504 DB, Netherlands
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Weert, 6001 BE, Netherlands
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Zwolle, 8011JW, Netherlands
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Auckland, 1030, New Zealand
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Auckland, 1640, New Zealand
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Christchurch, 8011, New Zealand
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Hastings, 4120, New Zealand
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Nelson, 7010, New Zealand
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Palmerston North, 4410, New Zealand
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Bergen, 5021, Norway
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Bodø, 8092, Norway
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Drammen, 3004, Norway
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Hamar, 2318, Norway
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Kongsvinger, 2212, Norway
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Kristiansund, 6508, Norway
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Lillehammer, 2629, Norway
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Oslo, 0319, Norway
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Oslo, 0407, Norway
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Oslo, 0514, Norway
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Stavanger, 4011, Norway
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Tynset, 2500, Norway
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Cusco, Departamento de Cusco, Peru
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Ica, Ica, Peru
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Chiclayo, Lambayeque, Peru
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Lima, Lima Province, LIMA 11, Peru
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Lima, Lima Province, LIMA 13, Peru
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Lima, Lima Province, LIMA 18, Peru
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Lima, Lima Province, LIMA 1, Peru
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Lima, Lima Province, LIMA 27, Peru
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Lima, Lima Province, LIMA 31, Peru
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Lima, Lima Province, LIMA 33, Peru
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Lima, Lima Province, LIMA 39, Peru
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Lima, Lima Province, LIMA 41, Peru
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Bellavista, Provincia Constitucional del Callao, CALLAO 2, Peru
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Callao, Provincia Constitucional del Callao, CALLAO 2, Peru
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Węgrów, Mazowiekie, 07-100, Poland
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Bialystok, 15-276, Poland
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Bydgoszcz, 85-826, Poland
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Bytom, 41-902, Poland
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Częstochowa, 42-200, Poland
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Elblag, 82-300, Poland
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Gdynia, 81-423, Poland
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Grodzisk Mazowiecki, 05-825, Poland
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Inowrocław, 88-100, Poland
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Kielce, 25-736, Poland
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Kościerzyna, 83-400, Poland
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Krakow, 31-202, Poland
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Krakow, 31-501, Poland
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Lodz, 91-347, Poland
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Lodz, 91-425, Poland
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Lublin, 20-089, Poland
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Lublin, 20-954, Poland
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Opole, 45-418, Poland
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Ostrowiec Świętokrzyski, 27-400, Poland
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Poznan, 60-479, Poland
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Płock, 09-402, Poland
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Radom, 26617, Poland
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Rzeszów, 35-301, Poland
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Szczecin, 70-111, Poland
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Słupsk, 76-200, Poland
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Tarnów, 33-100, Poland
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Torun, 87-100, Poland
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Warsaw, 01-809, Poland
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Warsaw, 02-507, Poland
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Warsaw, 04-628, Poland
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Warsaw, 04-749, Poland
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Włocławek, 87-800, Poland
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Zabrze, 41-800, Poland
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Zielona Góra, 65-046, Poland
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Cidra, 00739, Puerto Rico
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San Juan, 00917, Puerto Rico
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Arad, 310158, Romania
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Baia Mare, 430031, Romania
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Brăila, 810249, Romania
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Bucharest, 011461, Romania
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Bucharest, 021659, Romania
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Bucharest, 042122, Romania
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Bucharest, 050098, Romania
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Craiova, 200642, Romania
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Oradea, 410169, Romania
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Piteşti, 110884, Romania
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Sibiu, 550245, Romania
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Târgu Mureş, 540136, Romania
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Timișoara, 300736, Romania
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Barnaul, 656055, Russia
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Chelyabinsk, 454136, Russia
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Kaluga, 248007, Russia
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Kazan', 420029, Russia
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Kemerovo, 650002, Russia
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Krasnoyarsk, 660058, Russia
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Krasnoyarsk, 660062, Russia
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Moscow, 105229, Russia
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Moscow, 109240, Russia
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Moscow, 111539, Russia
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Moscow, 115093, Russia
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Moscow, 115280, Russia
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Moscow, 117292, Russia
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Moscow, 117593, Russia
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Moscow, 119048, Russia
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Moscow, 119620, Russia
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Moscow, 119991, Russia
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Moscow, 121359, Russia
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Moscow, 121374, Russia
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Moscow, 121552, Russia
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Moscow, 123182, Russia
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Moscow, 125206, Russia
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Moscow, 125284, Russia
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Moscow, 125424, Russia
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Moscow, 127018, Russia
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Moscow, 127473, Russia
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Moscow, 127644, Russia
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Moscow, 129301, Russia
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Moscow, 129327, Russia
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Moscow, 129336, Russia
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Moscow, 19991, Russia
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Moscow Reg. Zhekeznodorozhniy, 143920, Russia
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Nizhny Novgorod, 603003, Russia
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Nizhny Novgorod, 603005, Russia
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Nizhny Novgorod, 603035, Russia
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Novosibirsk, 630003, Russia
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Novosibirsk, 630008, Russia
Local Institution
Novosibirsk, 630047, Russia
Local Institution
Novosibirsk, 630089, Russia
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Odintsovo, 143000, Russia
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Penza, 440026, Russia
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Perm, 614036, Russia
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Rostov-on-Don, 344011, Russia
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Ryazan, 390026, Russia
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Saint Petersburg, 190000, Russia
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Saint Petersburg, 191104, Russia
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Saint Petersburg, 192242, Russia
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Saint Petersburg, 193079, Russia
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Saint Petersburg, 193144, Russia
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Saint Petersburg, 193312, Russia
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Saint Petersburg, 194156, Russia
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Saint Petersburg, 194291, Russia
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Saint Petersburg, 195067, Russia
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Saint Petersburg, 196601, Russia
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Saint Petersburg, 197110, Russia
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Saint Petersburg, 198013, Russia
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Saint Petersburg, 198205, Russia
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Saratov, 410028, Russia
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Saratov, 410054, Russia
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Tomsk, 634012, Russia
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Tver', 170036, Russia
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Tyumen, 625023, Russia
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Vasilievsky Island, 199106, Russia
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Voronezh, 394065, Russia
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Yaroslavl, 150002, Russia
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Yaroslavl, 150003, Russia
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Yaroslavl, 150030, Russia
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Yaroslavl, 150062, Russia
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Yekaterinburg, 620109, Russia
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Yekaterinburg, 620144, Russia
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Zhukovskiy, 140180, Russia
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Singapore, 168752, Singapore
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Singapore, 768828, Singapore
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Banská Bystrica, 97405, Slovakia
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Bratislava, 833 48, Slovakia
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Košice, 040 01, Slovakia
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Košice, 040 11, Slovakia
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Košice, 04001, Slovakia
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Kráľovský Chlmec, 07701, Slovakia
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Liptovský Hrádok, 033 80, Slovakia
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Lučenec, 984 01, Slovakia
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Martin, 03639, Slovakia
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Nitra, 949 01, Slovakia
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Port Elizabeth, Eastern Cape, 6001, South Africa
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Port Elizabeth, Eastern Cape, 6045, South Africa
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Bloemfontein, Free State, 9300, South Africa
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Bloemfontein, Free State, 9301, South Africa
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Centurion, Gauteng, 0157, South Africa
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Wapadrand - Pretoria, Gauteng, 0049, South Africa
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Durban, KwaZulu-Natal, 4001, South Africa
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Durban, KwaZulu-Natal, 4091, South Africa
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Durban, KwaZulu-Natal, 4092, South Africa
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Umhlanga, KwaZulu-Natal, 4321, South Africa
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Bellville, Western Cape, 7530, South Africa
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Kuils River, Western Cape, 7580, South Africa
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Pinelands, Western Cape, 7405, South Africa
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Somerset West, Western Cape, 7130, South Africa
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Worcester, Western Cape, 6850, South Africa
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Johannesburg, 2013, South Africa
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Wŏnju, Gangwon-do, 220-701, South Korea
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Yangsan, Gyeongangnam-Do, 626-770, South Korea
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Anyang-si, Gyeonggi-do, 431-070, South Korea
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Guri-si, Gyeonggi-do, 471-701, South Korea
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Jinju, Gyeongsangam-Do, 660-702, South Korea
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Daegu, 705718, South Korea
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Goyang, 410-773, South Korea
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Gwangju, 501-757, South Korea
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Incheon, 400-711, South Korea
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Incheon, 405-760, South Korea
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Jeonbuk, 561-712, South Korea
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Pusan, 602-739, South Korea
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Seoul, 137-701, South Korea
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Seoul, 138-736, South Korea
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Seoul, 152-703, South Korea
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Suwon, 443-721, South Korea
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Villajoyosa, Alicante, 03570, Spain
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Almería, Almeria, 04120, Spain
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Oviedo, Asturas, 33006, Spain
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Cáceres, Caceres, 10003, Spain
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Figueres, Gerona, 17600, Spain
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Madrid, Madrid, 28007, Spain
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Madrid, Madrid, 28031, Spain
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Madrid, Madrid, 28041, Spain
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San Sebastián de los Reyes, Madrid, 28702, Spain
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Santiago de Compostela, Santiago de Compostela, 15706, Spain
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Barcelona, 08003, Spain
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Barcelona, 08035, Spain
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El Ejido, 04700, Spain
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Granada, 18014, Spain
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Lleida, 25198, Spain
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Lugo, 27004, Spain
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Madrid, 28006, Spain
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Madrid, 28046, Spain
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Madrid, 28050, Spain
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Málaga, 29010, Spain
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Seville, 41071, Spain
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Tarragona, 43007, Spain
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Torrevieja, 03186, Spain
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Valencia, 46014, Spain
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Valladolid, 47012, Spain
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Zaragoza, 50009, Spain
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Eskilstuna, 631 88, Sweden
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Halmstad, 30185, Sweden
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Helsingborg, 251 87, Sweden
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Karlskoga, 691 81, Sweden
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Karlstad, 651 85, Sweden
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Köping, 731 81, Sweden
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Lidköping, 531 85, Sweden
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Mölndal, 43180, Sweden
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Skövde, 541 85, Sweden
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Stockholm, 141 86, Sweden
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Stockholm, 171 76, Sweden
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Uppsala, 751 85, Sweden
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Vaxjo, 351 85, Sweden
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Lugano, Canton Ticino, 6900, Switzerland
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Geneva, 1211, Switzerland
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Sankt Gallen, 9007, Switzerland
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Zurich, 8063, Switzerland
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Zurich, 8091, Switzerland
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Beşevler, Ankara, 06500, Turkey (Türkiye)
Local Institution
Isanbul, Haseki, Turkey (Türkiye)
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Bornova, İzmir, 35100, Turkey (Türkiye)
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Ankara, 06100, Turkey (Türkiye)
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Diyarbakır, 21280, Turkey (Türkiye)
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Isparta, 32100, Turkey (Türkiye)
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Konya, 42080, Turkey (Türkiye)
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Kırıkkale, Turkey (Türkiye)
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Chernivtsy, 58013, Ukraine
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Dnipropetrovsk, 49006, Ukraine
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Dnipropetrovsk, 49060, Ukraine
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Donetsk, 83003, Ukraine
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Donetsk, 83045, Ukraine
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Donetsk, 83114, Ukraine
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Ivano-Frankivsk, 76025, Ukraine
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Kharkiv, 61002, Ukraine
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Kharkiv, 61018, Ukraine
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Kharkiv, 61039, Ukraine
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Kharkiv, 61115, Ukraine
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Kharkiv, 61176, Ukraine
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Kyiv, 02091, Ukraine
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Kyiv, 02660, Ukraine
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Kyiv, 03115, Ukraine
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Kyiv, 03151, Ukraine
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Luhansk, 91016, Ukraine
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Lutsk, 43024, Ukraine
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Lviv, 79010, Ukraine
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Lviv, 79015, Ukraine
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Mykolayiv, 54003, Ukraine
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Odesa, 65014, Ukraine
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Odesa, 65059, Ukraine
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Simferopol, 95026, Ukraine
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Vinnitsa, 21029, Ukraine
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Zhaporizhzhya, 69000, Ukraine
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Belfast, Antrim, BT9 7AB, United Kingdom
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Belfast, Armagh, BT12 6BA, United Kingdom
Local Institution
Portadown, Armagh, BT63 5QQ, United Kingdom
Local Institution
Ayr, Ayrshire, KA6 6DX, United Kingdom
Local Institution
Kilmarnock, Ayrshire, KA2 0BE, United Kingdom
Local Institution
Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
Local Institution
Chesterfield, Derbyshire, S445BL, United Kingdom
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Dumfries, Dumfriesshire, DG1 4AP, United Kingdom
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Cottingham, East Yorkshire, HU16 5JQ, United Kingdom
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Basildon, Essex, SS16 5NL, United Kingdom
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Chelmsford, Essex, CM1 7ET, United Kingdom
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Romford, Essex, RM7 0AG, United Kingdom
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Royal Tunbridge Wells, Kent, TN4 8AT, United Kingdom
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Blackpool, Lancashire, FY3 8NR, United Kingdom
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Scunthorpe, Lincolnshire, DN15 7BH, United Kingdom
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Harrow, Middlesex, HA1 3UJ, United Kingdom
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Worksop, Nottinghamshire, S18 0BD, United Kingdom
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Doncaster, South Yorkshire, DN2 5LT, United Kingdom
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New Castle Upon Tyne, Tyne and Wear, NE7 7DN, United Kingdom
Related Publications (8)
Sharma A, Hagstrom E, Wojdyla DM, Neely ML, Harrington RA, Wallentin L, Alexander JH, Goodman SG, Lopes RD; Apixaban for Prevention of Acute Ischemic Safety Events APPRAISE-2 Steering Committee and Investigators. Clinical consequences of bleeding among individuals with a recent acute coronary syndrome: Insights from the APPRAISE-2 trial. Am Heart J. 2019 Sep;215:106-113. doi: 10.1016/j.ahj.2019.05.004. Epub 2019 May 11.
PMID: 31310855DERIVEDInohara T, Pieper K, Wojdyla DM, Patel MR, Jones WS, Tricoci P, Mahaffey KW, James SK, Alexander JH, Lopes RD, Wallentin L, Ohman EM, Roe MT, Vemulapalli S. Incidence, timing, and type of first and recurrent ischemic events in patients with and without peripheral artery disease after an acute coronary syndrome. Am Heart J. 2018 Jul;201:25-32. doi: 10.1016/j.ahj.2018.03.013. Epub 2018 Mar 28.
PMID: 29910052DERIVEDSherwood MW, Lopes RD, Sun JL, Liaw D, Harrington RA, Wallentin L, Laskowitz DT, James SK, Goodman SG, Darius H, Lewis BS, Gibson CM, Pieper KS, Alexander JH. Apixaban following acute coronary syndromes in patients with prior stroke: Insights from the APPRAISE-2 trial. Am Heart J. 2018 Mar;197:1-8. doi: 10.1016/j.ahj.2017.09.020. Epub 2017 Oct 24.
PMID: 29447769DERIVEDGuimaraes PO, Lopes RD, Stevens SR, Zimerman A, Wruck L, James SK, Haque G, Giraldez RRCV, Alexander JH, Alexander KP. Reporting Clinical End Points and Safety Events in an Acute Coronary Syndrome Trial: Results With Integrated Collection. J Am Heart Assoc. 2017 Apr 24;6(4):e005490. doi: 10.1161/JAHA.117.005490.
PMID: 28438739DERIVEDHess CN, James S, Lopes RD, Wojdyla DM, Neely ML, Liaw D, Hagstrom E, Bhatt DL, Husted S, Goodman SG, Lewis BS, Verheugt FWA, De Caterina R, Ogawa H, Wallentin L, Alexander JH. Apixaban Plus Mono Versus Dual Antiplatelet Therapy in Acute Coronary Syndromes: Insights From the APPRAISE-2 Trial. J Am Coll Cardiol. 2015 Aug 18;66(7):777-787. doi: 10.1016/j.jacc.2015.06.027.
PMID: 26271059DERIVEDKhan R, Lopes RD, Neely ML, Stevens SR, Harrington RA, Diaz R, Cools F, Jansky P, Montalescot G, Atar D, Lopez-Sendon J, Flather M, Liaw D, Wallentin L, Alexander JH, Goodman SG; Apixaban for Prevention of Acute Ischemic Safety Events (APPRAISE)-2 Steering Committee and Investigators. Characterising and predicting bleeding in high-risk patients with an acute coronary syndrome. Heart. 2015 Sep;101(18):1475-84. doi: 10.1136/heartjnl-2014-307346. Epub 2015 Jun 24.
PMID: 26109589DERIVEDMahaffey KW, Hager R, Wojdyla D, White HD, Armstrong PW, Alexander JH, Tricoci P, Lopes RD, Ohman EM, Roe MT, Harrington RA, Wallentin L. Meta-analysis of intracranial hemorrhage in acute coronary syndromes: incidence, predictors, and clinical outcomes. J Am Heart Assoc. 2015 Jun 18;4(6):e001512. doi: 10.1161/JAHA.114.001512.
PMID: 26089177DERIVEDAlexander JH, Lopes RD, James S, Kilaru R, He Y, Mohan P, Bhatt DL, Goodman S, Verheugt FW, Flather M, Huber K, Liaw D, Husted SE, Lopez-Sendon J, De Caterina R, Jansky P, Darius H, Vinereanu D, Cornel JH, Cools F, Atar D, Leiva-Pons JL, Keltai M, Ogawa H, Pais P, Parkhomenko A, Ruzyllo W, Diaz R, White H, Ruda M, Geraldes M, Lawrence J, Harrington RA, Wallentin L; APPRAISE-2 Investigators. Apixaban with antiplatelet therapy after acute coronary syndrome. N Engl J Med. 2011 Aug 25;365(8):699-708. doi: 10.1056/NEJMoa1105819. Epub 2011 Jul 24.
PMID: 21780946DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Bristol-Myers Squibb Study Director
- Organization
- Bristol-Myers Squibb
Study Officials
- STUDY DIRECTOR
Bristol-Myers Squibb
Bristol-Myers Squibb
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 28, 2009
First Posted
January 29, 2009
Study Start
March 1, 2009
Primary Completion
March 1, 2011
Study Completion
March 1, 2011
Last Updated
January 27, 2016
Results First Posted
January 27, 2016
Record last verified: 2015-12