NCT05714202

Brief Summary

The purpose of this study is to compare event-free survival (EFS) in participants with Bacillus Calmette-Guerin (BCG)-naive high-risk non-muscle invasive bladder cancer (HR-NMIBC), including high-grade papillary Ta, any T1, or carcinoma in situ (CIS), between TAR-200 plus cetrelimab (Group A) and TAR-200 alone (Group C) versus intravesical BCG (Group B).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
1,135

participants targeted

Target at P75+ for phase_3

Timeline
41mo left

Started Mar 2023

Longer than P75 for phase_3

Geographic Reach
21 countries

240 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress48%
Mar 2023Sep 2029

First Submitted

Initial submission to the registry

January 27, 2023

Completed
10 days until next milestone

First Posted

Study publicly available on registry

February 6, 2023

Completed
2 months until next milestone

Study Start

First participant enrolled

March 23, 2023

Completed
6.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 18, 2029

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 18, 2029

Last Updated

April 13, 2026

Status Verified

April 1, 2026

Enrollment Period

6.5 years

First QC Date

January 27, 2023

Last Update Submit

April 9, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Event-free Survival (EFS)

    EFS is defined as the time from randomization to either the time of the first recurrence of high-risk disease, progression, or death due to any cause, whichever occurs first. For participants with carcinoma In-situ (CIS), persistent disease at 6 months (Week 24) is also considered an EFS event. Progression is defined as: an increase of stage from Ta to T1 or from CIS to T1 or progression to muscle invasive bladder cancer (MIBC) (T greater than or equal to \[\>=\] 2) or to lymph node (N+) or to distant disease (M+), whichever occurs first.

    Up to 5 years 2 months

Secondary Outcomes (12)

  • Overall Complete Response (CR) Rate

    Up to 5 years 2 months

  • Duration of CR

    Up to 5 years 2 months

  • Recurrence-Free Survival (RFS)

    Up to 5 years 2 months

  • Time to Progression (TTP)

    Up to 5 years 2 months

  • Overall Survival (OS)

    Up to 5 years 2 months

  • +7 more secondary outcomes

Study Arms (3)

Treatment Group A: TAR-200 + Cetrelimab

EXPERIMENTAL

Participants will receive intravesical TAR-200 once every 3 weeks (Q3W) and cetrelimab.

Drug: TAR-200Biological: Cetrelimab

Treatment Group B: Bacillus Calmette-Guerin (BCG) Vesiculture

ACTIVE COMPARATOR

Participants will receive intravesical BCG once every week for 6 weeks (induction) and then followed by once every week for 3 weeks starting at Weeks 12, 24, 48, 72, and 96 (maintenance).

Biological: BCG Vesiculture

Treatment Group C: TAR-200 Alone

EXPERIMENTAL

Participants will receive intravesical TAR-200 alone once Q3W.

Drug: TAR-200

Interventions

TAR-200 will be administered intravesically.

Also known as: JNJ-17000139
Treatment Group A: TAR-200 + CetrelimabTreatment Group C: TAR-200 Alone
CetrelimabBIOLOGICAL

Cetrelimab will be administered.

Also known as: JNJ-63723283
Treatment Group A: TAR-200 + Cetrelimab
BCG VesicultureBIOLOGICAL

BCG will be administered intravesically.

Treatment Group B: Bacillus Calmette-Guerin (BCG) Vesiculture

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Histologically confirmed initial diagnosis by local pathology (within 90 days of the most recent signed informed consent) of high grade non-muscle invasive bladder cancer (HR-NMIBC) (high-grade Ta, any T1 or carcinoma in-situ \[CIS\]), in participants who are Bacillus Calmette Guérin (BCG)-naïve
  • BCG-naïve (participants who have not received prior intravesical BCG or who previously received but stopped BCG more than 3 years before date of randomization are eligible)
  • All visible papillary disease must be fully resected (absent) prior to date of randomization and documented at baseline cystoscopy. Local urine cytology at screening must be negative or atypical (for high-grade urothelial carcinoma \[HGUC\]) for patients with papillary only disease (without CIS)
  • Eastern Cooperative Oncology Group (ECOG) performance status Grade 0, 1, or 2
  • All adverse events associated with any prior surgery and/or intravesical therapy must have resolved to common terminology criteria for adverse events (CTCAE) version 5.0 Grade less than (\<) 2 prior to date of randomization
  • Participants must be willing to undergo all study procedures

You may not qualify if:

  • Presence or history of histologically confirmed, muscle invasive, locally advanced, nonresectable, or metastatic urothelial carcinoma (that is, greater than and equal to \[\>=\] T2)
  • Must not have had urothelial carcinoma or histological variant at any site outside of the urinary bladder (that is, urethra, ureter, or renal pelvis). Ta/any T1/CIS of the upper urinary tract (including renal pelvis and ureter) is allowable if treated with complete nephroureterectomy more than 24 months prior to randomization
  • Presence of any bladder or urethral anatomic feature (example, urethral stricture) that, in the opinion of the investigator, may prevent the safe insertion, indwelling use, removal of TAR-200 or administration of intravesical BCG. Participants with tumors involving the prostatic urethra in men will be excluded
  • A history of clinically significant polyuria with recorded 24-hour urine volumes greater than 4000 milliliters (mL)
  • Indwelling catheters are not permitted; however, intermittent catheterization is acceptable

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (240)

Mayo Clinic

Scottsdale, Arizona, 85259, United States

Location

Arkansas Urology

Little Rock, Arkansas, 72211, United States

Location

VA Long Beach Health Care System

Long Beach, California, 90822, United States

Location

Genesis Research, LLC - West Coast Urology

Los Alamitos, California, 90720, United States

Location

Cedars Sinai Medical Center

Los Angeles, California, 90048, United States

Location

UC Davis Comprehensive Cancer Center

Sacramento, California, 95630, United States

Location

Genesis Research

San Diego, California, 92123, United States

Location

Providence Saint Johns Cancer Institute

Santa Monica, California, 90404, United States

Location

Providence Medical Foundation

Santa Rosa, California, 95403, United States

Location

Colorado Clinical Research

Lakewood, Colorado, 80228, United States

Location

Urological Research Network

Hialeah, Florida, 33016, United States

Location

Orlando Health Cancer Institute

Orlando, Florida, 32806, United States

Location

Sarasota Memorial Hospital

Sarasota, Florida, 34239, United States

Location

Grady Memorial Hospital

Atlanta, Georgia, 30303, United States

Location

The Emory Clinic Department of Urology

Atlanta, Georgia, 30322, United States

Location

Northwestern University

Chicago, Illinois, 60611, United States

Location

Duly Health and Care

Lisle, Illinois, 60532, United States

Location

Blessing Hospital

Quincy, Illinois, 62301, United States

Location

Urology of Indiana

Carmel, Indiana, 46032, United States

Location

First Urology

Jeffersonville, Indiana, 47130, United States

Location

AMR Kansas City Oncology

Merriam, Kansas, 66204, United States

Location

Wichita Urology Group

Wichita, Kansas, 67226, United States

Location

Chesapeake Urology Research Associates

Hanover, Maryland, 21076, United States

Location

Lahey Hospital & Medical Center

Burlington, Massachusetts, 01805, United States

Location

University of Michigan

Ann Arbor, Michigan, 48109, United States

Location

University Of Minnesota

Minneapolis, Minnesota, 55455, United States

Location

Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States

Location

The Urology Center, PC

Omaha, Nebraska, 68114, United States

Location

Cooper Health System MD Anderson Cancer Center at Cooper

Camden, New Jersey, 08103, United States

Location

VA NY Harbor Healthcare System

New York, New York, 10010, United States

Location

Icahn School of Medicine at Mt. Sinai

New York, New York, 10029, United States

Location

Associated Medical Professionals of Ny

Syracuse, New York, 13210, United States

Location

SUNY Upstate Med Univ

Syracuse, New York, 13210, United States

Location

Vidant Urology - Greenville

Greenville, North Carolina, 27834, United States

Location

Cleveland Clinic

Cleveland, Ohio, 44195, United States

Location

Central Ohio Urology Group

Gahanna, Ohio, 43230, United States

Location

Centers for Advanced Urology LLC d b a MidLantic Urology

Bala-Cynwyd, Pennsylvania, 19004, United States

Location

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States

Location

UPMC Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States

Location

Carolina Urologic Research Center

Myrtle Beach, South Carolina, 29572, United States

Location

Urology Associates

Nashville, Tennessee, 37209, United States

Location

Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

Location

Urology Austin

Austin, Texas, 78745, United States

Location

Urology Clinics of North Texas

Dallas, Texas, 75231, United States

Location

Houston Metro Urology

Houston, Texas, 77027, United States

Location

Houston Methodist Hospital

Houston, Texas, 77030, United States

Location

Urology San Antonio Research

San Antonio, Texas, 78229, United States

Location

Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States

Location

George E. Wahlen VAMC

Salt Lake City, Utah, 84148, United States

Location

Urology Of Virginia, Pllc

Virginia Beach, Virginia, 23462, United States

Location

Spokane Urology

Spokane, Washington, 99202, United States

Location

Hospital Italiano de Buenos Aires

Buenos Aires, C1199, Argentina

Location

Sociedade Beneficente de Senhoras Hospital Sirio Libanes

Buenos Aires, C1417, Argentina

Location

Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica

Córdoba, 5000, Argentina

Location

Centro Urologico Profesor Bengio

Córdoba, X5000KPH, Argentina

Location

Hospital Privado Centro Medico de Cordoba

Córdoba, X5016KEH, Argentina

Location

Hospital Privado de la Comunidad

Mar del Plata, B7602CBM, Argentina

Location

Instituto Medico Rio Cuarto

Río Cuarto, 5800, Argentina

Location

Austin Health

Heidelberg, 3084, Australia

Location

Macquarie University Hospital

Macquarie University, 2109, Australia

Location

Hollywood Private Hospital

Nedlands, 6009, Australia

Location

Mater Hospital Brisbane

South Brisbane, 4101, Australia

Location

ZNA Middelheim

Antwerp, 2020, Belgium

Location

AZ Sint-Jan

Bruges, 8000, Belgium

Location

AZ Sint-Lucas

Bruges, 8310, Belgium

Location

AZ Maria Middelares

Ghent, 9000, Belgium

Location

UZ Gent

Ghent, 9000, Belgium

Location

Centre Hospitalier de l'Ardenne

Libramont-Chevigny, 6800, Belgium

Location

AZ Delta

Roeselare, 8800, Belgium

Location

Vitaz

Sint-Niklaas, 9100, Belgium

Location

GZA Ziekenhuizen- Campus St Augustinus

Wilrijk, 2610, Belgium

Location

Fundacao Pio XII

Barretos, 14784-400, Brazil

Location

NAIC Nair Antunes Instituto do Cancer

Bauru, 17033-495, Brazil

Location

Universidade Estadual De Campinas

Campinas, 13083-888, Brazil

Location

Liga Paranaense de Combate ao Cancer

Curitiba, 81520 060, Brazil

Location

Liga Norte Riograndense Contra O Cancer

Natal, 59075-740, Brazil

Location

Irmandade Santa Casa de Misericordia de Porto Alegre

Porto Alegre, 90050-170, Brazil

Location

Hospital Regional do Cancer - Hospital de Esperança

Presidente Prudente, 19013-050, Brazil

Location

Hospital Sao Rafael

Salvador, 41253 190, Brazil

Location

Hospital Ana Nery Santa Cruz do Sul

Santa Cruz do Sul, 96835-090, Brazil

Location

CEPHO Centro de Estudos e Pesquisa de Hematologia e Oncologia

Santo André, 09060-870, Brazil

Location

Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo

São Paulo, 01246 000, Brazil

Location

Fundacao Antonio Prudente A C Camargo Cancer Center

São Paulo, 01508-010, Brazil

Location

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein

São Paulo, 05652 900, Brazil

Location

Real e Benemerita Associacao Portuguesa de Beneficencia

São Paulo, 1321 001, Brazil

Location

Nova Scotia Health Authority

Halifax, Nova Scotia, B3H 2Y9, Canada

Location

St Josephs Healthcare Hamilton

Hamilton, Ontario, L8N 4A6, Canada

Location

Princess Margaret Cancer Centre University Health Network

Toronto, Ontario, M5G 1Z5, Canada

Location

CHUM - Centre hospitalier universitaire de Montreal

Montreal, Quebec, H2X 3E4, Canada

Location

CHU de Quebec Universite Laval Hopital de l Enfant Jesus

Québec, Quebec, G1J1Z4, Canada

Location

Unite de Recherche Clinique du CISSS des Laurentides

Saint Jerome Quebec, Quebec, J7Z 2V4, Canada

Location

Peking University First Hospital

Beijing, 100034, China

Location

Beijing Hospital

Beijing, 100730, China

Location

Beijing Luhe Hospital, Capital Medical University

Beijing, 101100, China

Location

The First Bethune Hospital of Jilin University

Changchun, 130499, China

Location

Hunan Province Cancer Hospital

Changsha, 410013, China

Location

West China Hospital Sichuan University

Chengdu, 610044, China

Location

Chongqing University Cancer Hospital

Chongqing, 400000, China

Location

People's Hospital of Deyang City

Deyang, 618000, China

Location

Sun Yat Sen University Cancer Center

Guangzhou, 430030, China

Location

Zhejiang Provincial People's Hospital

Hangzhou, 310000, China

Location

Sir Run Run Shaw Hospital Zhejiang University School of Medicine

Hangzhou, 310016, China

Location

Nanjing Drum Tower Hospital

Nanjing, 210008, China

Location

The First Affiliated Hospital of Ningbo University

Ningbo, 315010, China

Location

Ruijing Hospital Affiliated To Shanghai Jiaotong University School Of Medicine

Shanghai, 200025, China

Location

Huadong Hospital Affiliated to Fudan University

Shanghai, 200400, China

Location

Shengjing Hospital Of China Medical University

Shenyang, 110004, China

Location

The Second Hospital Of Tianjin Medical University

Tianjin, 300211, China

Location

The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, 325000, China

Location

TongJi Hospital of TongJi Medical College of Huazhong University of Science & Technology

Wuhan, 430030, China

Location

First Affiliated Hospital of Medical College of Xi'an Jiaotong University

Xi'an, 710061, China

Location

Yantai Yuhuangding Hospital

Yantai, 264000, China

Location

Henan Cancer Hospital

Zhengzhou, 450008, China

Location

Fakultni nemocnice u sv. Anny v Brne

Brno, 65691, Czechia

Location

Fakultni nemocnice Hradec Kralove

Hradec Králové, 500 05, Czechia

Location

Krajská nemocnice Liberec a.s.

Liberec, 460 01, Czechia

Location

Fakultni nemocnice Olomouc

Olomouc, 779 00, Czechia

Location

Fakultni nemocnice Kralovske Vinohrady

Prague, 100 34, Czechia

Location

Thomayerova nemocnice, Onkologicka klinika

Prague, 140 59, Czechia

Location

Fakultni nemocnice v Motole

Prague, 15006, Czechia

Location

Polyclinique Bordeaux Nord Acquitaine

Bordeaux, 33000, France

Location

CHU Gabriel-Montpied

Clermont-Ferrand, 63003, France

Location

CHU Grenoble

Grenoble, 38043, France

Location

Polyclinique de Limoges - Francois Chenieux

Limoges, 87000, France

Location

Hôpital Edouard Herriot

Lyon, 69437, France

Location

CHU de Nantes hotel Dieu

Nantes, 44093, France

Location

CHU Nimes

Nîmes, 30029, France

Location

Centre Hospitalier Regional d'Orleans (CHRO) - Hopital La Source

Orléans, 45067, France

Location

Hôpital Universitaire Pitié-Salpêtrière

Paris, 75013, France

Location

Hopital Europeen Georges-Pompidou

Paris, 75015, France

Location

APHP - Hopital Bichat - Claude Bernard

Paris, 75018, France

Location

Groupe Hospitalier Diaconesses Croix Saint Simon

Paris, 75960, France

Location

Clinical La Croix Du Sud - Ramsay Santé

Quint-Fonsegrives, 31130, France

Location

Chu Rennes Hopital Pontchaillou

Rennes, 35000, France

Location

Institut de Cancerologie Strasbourg Europe ICANS

Strasbourg, 67200, France

Location

CHU Rangueil

Toulouse, 31059, France

Location

Urologische Partnerschaft Koln UPK

Cologne, 50968, Germany

Location

Urologicum Duisburg

Duisburg, 47169, Germany

Location

Universitatsklinikum Erlangen

Erlangen, 91054, Germany

Location

Universitatsklinikum Essen

Essen, 45147, Germany

Location

Universitaetsklinikum Frankfurt

Frankfurt am Main, 60590, Germany

Location

Universitaetsklinikum Freiburg

Freiburg im Breisgau, 79106, Germany

Location

Matthias Schulze - Germany

Markkleeberg, 04416, Germany

Location

Urologie Neandertal Praxis Mettmann

Mettmann, 40822, Germany

Location

Klinikum rechts der Isar an der Technischen Universitat Munchen

München, 81675, Germany

Location

Universitatsklinikum Munster

Münster, 48149, Germany

Location

Klinikum Nurnberg Nord

Nuremberg, 90419, Germany

Location

Medizinisches Versorgungszentrum - Urologie

Nuremberg, 90491, Germany

Location

Studienpraxis Urologie Nurtingen

Nürtingen, 72622, Germany

Location

Caritas-Krankenhaus St. Josef

Regensburg, 93053, Germany

Location

Universitat Tubingen

Tübingen, 72076, Germany

Location

Health Care Global Enterprises pvt Ltd

Bangalore, 560027, India

Location

Post Graduate Institute of Medical Education And Research PGIMER

Chandigarh, 160012, India

Location

Artemis Hospital

Gurugram, 122001, India

Location

Netaji Subhas chandra Bose Cancer Research Institute

Kolkata, 700094, India

Location

Tata Memorial Hospital

Mumbai, 400012, India

Location

CIMET s Inamdar Multispeciality Hospital

Pune, 411040, India

Location

Generale Regionale F. Miulli

Acquaviva delle Fonti, 70021, Italy

Location

Ospedale Cardinal Massaia

Asti, 14100, Italy

Location

Ospedale San Giuseppe Moscati di Avellino

Avellino, 83100, Italy

Location

Ospedale San Giacomo Apostolo, Guardia pediatrica territoriale

Castelfranco Veneto, 31033, Italy

Location

Ospedale San Raffaele di Milano

Milan, 20132, Italy

Location

Istituto Europeo di Oncologia

Milan, 20141, Italy

Location

Fondazione G Pascale Istituto Nazionale Tumori IRCCS

Naples, 80138, Italy

Location

Ospedale S. Maria Delle Croci

Ravenna, 48121, Italy

Location

Istituto Nazionale Tumori Regina Elena

Rome, 00128, Italy

Location

Fuji City General Hospital

Fuji-shi, 417-8567, Japan

Location

Kanazawa University Hospital

Kanazawa, 920 8641, Japan

Location

Nara Medical University Hospital

Kashihara-shi, 634-8522, Japan

Location

Kimitsu Chuo Hospital

Kisarazu-shi, 292-8535, Japan

Location

Kobe City Medical Center General Hospital

Kobe, 650 0047, Japan

Location

National Hospital Organization Kumamoto Medical Center

Kumamoto, 860-0008, Japan

Location

Nagano Municipal Hospital

Nagano, 381-8551, Japan

Location

Nagasaki University Hospital

Nagasaki, 852-8501, Japan

Location

JRC Nagasaki Genbaku Hospital

Nagasaki, 852-8511, Japan

Location

Saiseikai Narashino Hospital

Narashino-shi, 275-8580, Japan

Location

Ehime University Hospital

Toon-shi, 791-0295, Japan

Location

Toyama University Hospital

Toyama, 930 0194, Japan

Location

Yamaguchi University Hospital

Ube, 755-8505, Japan

Location

Yokohama City University Medical Center

Yokohama, 232 0024, Japan

Location

Consultorio Medico dentro del Hospital Angeles Acoxpa

Mexico City, 14308, Mexico

Location

Eme Red Hospitalaria

Mérida, 97000, Mexico

Location

Hospital Universitario Dr Jose Eleuterio Gonzalez

Monterrey, 64460, Mexico

Location

Avix Investigacion Clinica S C

Monterrey, 64710, Mexico

Location

Oncologico Potosino

San Luis Potosí City, 78260, Mexico

Location

Spaarne Gasthuis

Hoofddorp, 2134 TM, Netherlands

Location

Canisius-Wilhelmina Ziekenhuis

Nijmegen, 6524 KD, Netherlands

Location

Radboud Umcn

Nijmegen, 6525 GA, Netherlands

Location

Uniwersytecki Szpital Kliniczny w Bialymstoku

Bialystok, 15 276, Poland

Location

IN VIVO Sp. z o.o

Bydgoszcz, 85 048, Poland

Location

Wojewodzki Szpital Specjalistyczny im Stefana Kardynala Wyszynskiego SPZOZ

Lublin, 20 708, Poland

Location

Centrum Medyczne

Piotrkow Trybunalski, 97 300, Poland

Location

Clinical Research Center sp z o o MEDIC R s k

Poznan, 61 731, Poland

Location

Wojewodzki Szpital Specjalistyczny im Janusza Korczaka

Słupsk, 76-200, Poland

Location

Provita Poliklinika

Warsaw, 02-647, Poland

Location

Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy

Warsaw, 02-781, Poland

Location

Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu

Wroclaw, 50 556, Poland

Location

Ipo Coimbra

Coimbra, 3000-075, Portugal

Location

Uls Santa Maria - Hosp. Santa Maria

Lisbon, 1769 001, Portugal

Location

Uls Gaia Espinho

Vila Nova de Gaia, 4434 502, Portugal

Location

Pusan National University Hospital

Busan, 49241, South Korea

Location

Chungbuk National University Hospital

Cheongju-si, 28644, South Korea

Location

Kyungpook National University Chilgok Hospital

Daegu, 41404, South Korea

Location

Keimyung University Dongsan Hospital

Daegu, 42601, South Korea

Location

National Cancer Center

Gyeonggi-do, 10408, South Korea

Location

Chonnam National University Hwasun Hospital

Jeollanam-do, 58128, South Korea

Location

Korea University Anam Hospital

Seoul, 02841, South Korea

Location

Seoul National University Hospital

Seoul, 03080, South Korea

Location

Kangbuk Samsung Hospital

Seoul, 03181, South Korea

Location

Severance Hospital Yonsei University Health System

Seoul, 03722, South Korea

Location

Samsung Medical Center

Seoul, 06351, South Korea

Location

The Catholic University of Korea Seoul St Marys Hospital

Seoul, 06591, South Korea

Location

Hosp Univ A Coruna

A Coruña, 15006, Spain

Location

Hosp. Punta de Europa

Algeciras, 11207, Spain

Location

Fund. Puigvert

Barcelona, 08025, Spain

Location

Hosp. Puerta Del Mar

Cadiz, 11009, Spain

Location

Hosp. Gral. Univ. de Castellon

Castellon, 12004, Spain

Location

Hosp. Univ. de Bellvitge

L'Hospitalet de Llobregat, 08907, Spain

Location

Hosp. Univ. Lucus Augusti

Lugo, 27003, Spain

Location

Clinica Univ. de Navarra

Madrid, 28027, Spain

Location

Hosp. Univ. 12 de Octubre

Madrid, 28041, Spain

Location

Hosp. Univ. La Paz

Madrid, 28046, Spain

Location

Hosp Virgen de La Victoria

Málaga, 29010, Spain

Location

Hosp. Univ. Marques de Valdecilla

Santander, 39008, Spain

Location

Hosp. Clinico Univ. de Valencia

Valencia, 46010, Spain

Location

Kaohsiung Medical University Chung Ho Memorial Hospital

Kaohsiung City, 807, Taiwan

Location

Chang Kung Memorial Hospital

Kaohsiung City, 833, Taiwan

Location

China Medical University Hospital

Taichung, 404, Taiwan

Location

Taichung Veterans General Hospital

Taichung, 40705, Taiwan

Location

Taipei Veterans General Hospital

Taipei, 11217, Taiwan

Location

Linkou Chang Gung Memorial Hospital

Taoyuan District, 33382, Taiwan

Location

Western General Hospital

Edinburgh, EH4 2XU, United Kingdom

Location

St Bartholomews Hospital

London, EC1A 7BE, United Kingdom

Location

The Royal Marsden NHS Trust

London, SW3 6JJ, United Kingdom

Location

Charing Cross Hospital

London, W6 8RF, United Kingdom

Location

Derriford Hospital

Plymouth, PL6 8DH, United Kingdom

Location

Scunthorpe General Hospital

Scunthorpe, DN15 7BH, United Kingdom

Location

Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield, S10 2JF, United Kingdom

Location

Lister Hospital

Stevenage, SG1 4AB, United Kingdom

Location

Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital

Truro, TR1 3LJ, United Kingdom

Location

MeSH Terms

Conditions

Urinary Bladder Neoplasms

Condition Hierarchy (Ancestors)

Urologic NeoplasmsUrogenital NeoplasmsNeoplasms by SiteNeoplasmsFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesUrinary Bladder DiseasesUrologic DiseasesMale Urogenital Diseases

Study Officials

  • Janssen Research & Development, LLC Clinical Trial

    Janssen Research & Development, LLC

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR
Expanded Access
Yes

Study Record Dates

First Submitted

January 27, 2023

First Posted

February 6, 2023

Study Start

March 23, 2023

Primary Completion (Estimated)

September 18, 2029

Study Completion (Estimated)

September 18, 2029

Last Updated

April 13, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

The data sharing policy of the Janssen Pharmaceutical Companies of Johnson \& Johnson is available at www.janssen.com/clinical-trials/transparency. As noted on this site, requests for access to the study data can be submitted through Yale Open Data Access (YODA) Project site at yoda.yale.edu

More information

Locations