Association of Diabetes and Metabolic Syndrome With Severe Malaria in Cameroon

NCT05685875 | Unknown

• 2 other identifiers: 2022-05379-012020-05494
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 2

Brief Summary

The aim of this study is to investigate if diabetes, obesity and metabolic syndrome affects disease presentation and severity of malaria in adults in a hospital setting in Cameroon.

Conditions

Diabetes Mellitus, Type 2; Obesity; Metabolic Syndrome; Severe Malaria; Malaria,Falciparum

Outcome Measures

Primary Outcomes (1)

• Severe malaria

  P falciparum or other malaria species identified by microscopy and one or more criteria for severe malaria according to WHO 2015 definition.

  1 year

Secondary Outcomes (3)

• Malaria requiring in-patient care

  1 year

• Cerebral malaria

  1 year

• Severe malaria with kidney failure

  1 year

Interventions

diabetes OTHER

Diabetes and metabolic syndrome defined using criteria by IDF. Obesity defined as BMI\>=30

Also known as: obesity, metabolic syndrome

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adults, \>=20 years diagnosed with malaria (all Plasmodium species), will be recruited prospectively at both the outpatient department (OD), emergency department (ED) and hospital wards in Dschang and Bafoussam hospital. The malaria diagnosis can initially be by rapid test but should be confirmed by microscopy (for sepcies determination and parasite count). Patients will be invited to participate in the study after they return from laboratory investigations following routine consultation at the ED/OD if they have a positive malaria result. Participant recruitment will be conducted daily during normal work hours until the estimated study sample is attained. Patients that have seeked health care outside office hours and been admitted for malaria will be recruited the following day.

You may qualify if:

• Adults 20 years and above
• Diagnosed with malaria (all Plasmodium species, confirmed by microscopy)
• Have given consent to participate in the study

You may not qualify if:

• Children/youths \<20 years

Sponsors & Collaborators

• Karolinska Institutet: lead
• University of Dschang: collaborator

Study Sites (2)

Dschang Hospital

Dschang, West Cameroon, 43, Cameroon

RECRUITING

Bafoussam Regional Hospital

Bafoussam, West Region, 997, Cameroon

NOT YET RECRUITING

Related Publications (5)

• Wyss K, Wangdahl A, Vesterlund M, Hammar U, Dashti S, Naucler P, Farnert A. Obesity and Diabetes as Risk Factors for Severe Plasmodium falciparum Malaria: Results From a Swedish Nationwide Study. Clin Infect Dis. 2017 Sep 15;65(6):949-958. doi: 10.1093/cid/cix437.

  PMID: 28510633 BACKGROUND

• Danquah I, Bedu-Addo G, Mockenhaupt FP. Type 2 diabetes mellitus and increased risk for malaria infection. Emerg Infect Dis. 2010 Oct;16(10):1601-4. doi: 10.3201/eid1610.100399.

  PMID: 20875289 BACKGROUND

• Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, Stein C, Basit A, Chan JCN, Mbanya JC, Pavkov ME, Ramachandaran A, Wild SH, James S, Herman WH, Zhang P, Bommer C, Kuo S, Boyko EJ, Magliano DJ. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022 Jan;183:109119. doi: 10.1016/j.diabres.2021.109119. Epub 2021 Dec 6.

  PMID: 34879977 BACKGROUND

• Guidelines for the Treatment of Malaria. 3rd edition. Geneva: World Health Organization; 2015. Available from http://www.ncbi.nlm.nih.gov/books/NBK294440/

  PMID: 26020088 BACKGROUND

• Alberti KG, Zimmet P, Shaw J. Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006 May;23(5):469-80. doi: 10.1111/j.1464-5491.2006.01858.x.

  PMID: 16681555 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Venous blood samples for biochemistry analyses, malaria detection and Ag/serology (HIV) test

MeSH Terms

Conditions

Diabetes Mellitus, Type 2; Obesity; Metabolic Syndrome; Malaria; Malaria, Falciparum

Interventions

Adiposity; ANAPC16 protein, human

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Insulin Resistance; Hyperinsulinism; Protozoan Infections; Parasitic Diseases; Infections; Mosquito-Borne Diseases; Vector Borne Diseases

Intervention Hierarchy (Ancestors)

Body Fat Distribution; Body Weights and Measures; Body Constitution; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Body Composition; Biochemical Phenomena; Chemical Phenomena; Metabolism; Physiological Phenomena

Study Officials

• Anna Färnert, Prof

  Karolinska Institutet

  STUDY DIRECTOR

Central Study Contacts

Katja Wyss, PhD, MD

CONTACT

+46707352767; katja.wyss@ki.se

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: prinicpal investigator

Study Record Dates

• First Submitted: November 11, 2022
• First Posted: January 17, 2023
• Study Start: June 7, 2022
• Primary Completion: May 1, 2023
• Study Completion: June 1, 2023
• Last Updated: January 17, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

CA (2)