Diabetes, Metabolic Syndrome and Risk of Malaria in Cameroon

NCT06278181 | Completed DMC

• 1 other identifier: 2023/08/1545
• Study Type: observational
• Target: 406
• Locations: 1 country
• Sites: 1

Brief Summary

Non-communicable diseases (NCDs) such as diabetes are increasing in countries where malaria transmission is common. This study aims to investigate the relationship between NCDs and parasitic infections in Cameroon. The investigators will assess the risk of malaria, as well as other parasitic diseases, in a prospectively followed group of adults with diabetes, compared with those without diabetes. Malaria parasites and intestinal worms will be tested using blood and stool collected at four time points during a one-year follow-up. In addition, this project will investigate how natural protection against malaria is affected by diabetes and other risk factors for heart diseases.

Conditions

Malaria; Diabetes Mellitus; Metabolic Syndrome; Endemic

Outcome Measures

Primary Outcomes (1)

• asymptomatic malaria

  malaria parasites detected by RDT/microscopy/PCR

  1 year follow up

Secondary Outcomes (1)

• symptomatic malaria

  1 year follow up

Other Outcomes (2)

• schistosoma infection

  1 year follow up

• strongyloides infection

  1 year follow up

Study Arms (2)

Type 2 diabetes

Individuals with type 2 diabetes followed by the diabetes clinic at Limbe hospital

Diabetes free

Community controls without diabetes, referred by the patients with diabetes. The unexposed individuals referred should have approximately the same age, be of same sex and health cathment area as the exposed individual

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with type 2 diabetes identified at the outpatient diabetes clinic of Limbe Regional Hospital will be invited to the study. Community comparators matched on age and sex will be identified in the patients' family or in the home community to control for exposure to similar malaria transmission.

Sponsors & Collaborators

• Karolinska Institutet: lead
• University of Dschang: collaborator
• European Foundation for the Study of Diabetes: collaborator

Study Sites (1)

Limbe Regional Hospital

Limbe, Cameroon

Location

Biospecimen

Retention: SAMPLES WITH DNA

Venous EDTA blood sample will be collected at admission and stored frozen as plasma and packed cells for later analyses

MeSH Terms

Conditions

Malaria; Diabetes Mellitus; Metabolic Syndrome; Burkitt Lymphoma

Condition Hierarchy (Ancestors)

Protozoan Infections; Parasitic Diseases; Infections; Mosquito-Borne Diseases; Vector Borne Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Insulin Resistance; Hyperinsulinism; Epstein-Barr Virus Infections; Herpesviridae Infections; DNA Virus Infections; Virus Diseases; Tumor Virus Infections; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Lymphoma; Neoplasms by Histologic Type; Neoplasms; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases

Study Officials

• Katja Wyss, PhD MD

  Karolinska Institutet

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Graduate Student

Study Record Dates

• First Submitted: February 19, 2024
• First Posted: February 26, 2024
• Study Start: September 21, 2023
• Primary Completion: March 19, 2025
• Study Completion: March 19, 2025
• Last Updated: September 3, 2025

Record last verified: 2025-08

Locations

CA (1)