Dairy and Non-Dairy Alternatives Comparative on Metabolic Outcomes
The Effects of Dairy and Non-Dairy Alternatives on Glycemic and Appetite Regulation in Healthy Young Adults
1 other identifier
interventional
16
1 country
1
Brief Summary
The purpose of this study is to compare the acute effects of a single serving of dairy and non-dairy alternatives on post-treatment and post-meal glycemia, appetite, plasma amino acid concentrations, and gastrointestinal hormones levels.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable obesity
Started Feb 2022
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 28, 2022
CompletedStudy Start
First participant enrolled
February 28, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 28, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
March 31, 2023
CompletedFirst Posted
Study publicly available on registry
June 26, 2023
CompletedJune 26, 2023
June 1, 2023
Same day
February 28, 2022
June 22, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change in blood glucose level
Venous blood collection via catheter
Starting at the beginning of each sessions (0 min, before consumption of treatment) and every 15-30 minutes up to 160 minutes]. A total of 9 times.
Secondary Outcomes (3)
Subjective appetite
Measured every 15-30 minutes up to 160 minutes]. A total of 9 times.
Change in plasma metabolic and gut hormones (insulin, c-peptide, glucagon-like 1 receptor, glucagon-like 2 peptide and gastric inhibitory polypeptide)
Starting at the beginning of each session (0 minutes, before consumption of treatment) and every 15-30 minutes up to 160 minutes]. A total of 7 times.
Change in plasma amino acid concentrations
Starting at the beginning of each session (0 minutes, before consumption of treatment) and every 15-30 minutes up to 160 minutes]. A total of 7 times.
Study Arms (5)
Dairy-based Product 1
EXPERIMENTAL2% Cow's milk (Neilson, St-Laurent, Quebec)
Dairy-based Product 2
EXPERIMENTALRegular fat cheddar cheese (Armstrong, St-Laurent, Québec)
Plant-based Product 3:
EXPERIMENTALVanilla Soy Beverage (Silk, Broomfield, Colorado)
Plant-based Product 4
EXPERIMENTALVanilla Almond Beverage (Earth's Own, Vancouver, British Columbia)
Plant-based Product 5
EXPERIMENTALPlant-based Cheddar-Style Block (President' Choice, Brampton, Ontario)
Interventions
Crossover design: participants received all treatment arms in a randomized order
Eligibility Criteria
You may qualify if:
- BMI: ≥18.5 kg/m2 and ≤ 24.5 kg/m2'
- Fasting serum glucose: ≤ 5.5 mmol/L
- Frequent breakfast consumers
- Willing to maintain habitual diet, physical activity pattern, dietary supplement routine, and body weight throughout the trial
- Willing to abstain from alcohol consumption for 24 h prior to all test visits.
- Willing to avoid vigorous physical activity for 24 h prior to all test visits.
- Understanding the study procedures and willing to provide informed consent to participate in the study and authorization to release relevant protected health information to the study investigator.
You may not qualify if:
- Fasting blood glucose \> 5.5 mmol/L
- Smoking tobacco products and marijuana regularly
- Previous history of cardiovascular disease, diabetes, liver or kidney disease, inflammatory bowel disease, celiac disease, short bowel syndrome, any malabsorptive syndrome, pancreatitis, gallbladder or biliary disease
- Presence of gastrointestinal disorder or surgeries within the past year
- Consuming prescription or non-prescription drug, herbal or nutritional supplements known to affect blood glucose, appetite and/or any other outcomes of the study as per investigator's judgment
- Known to be pregnant or lactating, or planning on becoming pregnant in the next 12 months
- Irregular menstrual cycles (i.e., frequent missed cycles), menopausal or post- menopausal
- Breakfast skippers
- Currently trying to lose or gain weight and any weight gain or loss of at least 10 lbs in previous three months
- Known intolerance, sensitivity or allergy to dairy products (including milk and cheese)
- Consumption of powders/protein supplements
- Extreme dietary habits
- Excessive alcohol intake
- Restrained Eaters
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Nutritional Sciences, C. David Naylor Building
Toronto, Ontario, M5S 3H2, Canada
Related Publications (1)
Da Silva N, Anderson G, Amr A, Vien S, Fabek H. A comparison of the effects of dairy products with their plant-based alternatives on metabolic responses in healthy young Canadian adults: a randomized crossover study. Appl Physiol Nutr Metab. 2025 Jan 1;50:1-17. doi: 10.1139/apnm-2024-0158.
PMID: 39146559DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
G. Harvey Anderson, PhD
University of Toronto
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Masking Details
- Randomized, single-blinded
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
February 28, 2022
First Posted
June 26, 2023
Study Start
February 28, 2022
Primary Completion
February 28, 2022
Study Completion
March 31, 2023
Last Updated
June 26, 2023
Record last verified: 2023-06