GapCO2 and Respiratory Rate in Patients Under Volume Mechanical Ventilation

NCT02867943 | Unknown DMC

• 1 other identifier: PLA-105-ICU
• Study Type: observational
• Target: 28
• Locations: 0 countries
• Sites: N/A

Brief Summary

As an approximate of the difference between venous-to-arterial CO2 tension (∆PCO2), ∆PCO2 is proportional to CO2 production and inversely related to cardiac output (Fick equation). Anaerobic CO2 production is thought to occur when tissue hypoxia is present, mostly because of buffering of bicarbonate ions by the protons produced in excess secondary to the hydrolysis of adenosine triphosphate. Therefore ∆PCO2 has been proposed as a marker of tissue hypoxia.

Conditions

Shock

Keywords

sepsis, shock,Lactate,volume controlled ventilation

Outcome Measures

Primary Outcomes (1)

• Effects of respiratory rate on venous-to-arterial CO2 tension difference in septic shock patients Under Volume Mechanical Ventilation

  1 year

Study Arms (4)

respiratory rate is 10 breaths/min

GapCO2=Pv-aCO2 = PvCO2 - PaCO2; Effects of venous-to-arterial CO2 tension difference after increased respiratory rate.

Other: Effects of respiratory rate on gapCO2

respiratory rate is 12 breaths/min

GapCO2=Pv-aCO2 = PvCO2 - PaCO2; Effects of venous-to-arterial CO2 tension difference after increased respiratory rate.

Other: Effects of respiratory rate on gapCO2

respiratory rate is 14 breaths/min

GapCO2=Pv-aCO2 = PvCO2 - PaCO2; Effects of venous-to-arterial CO2 tension difference after increased respiratory rate.

Other: Effects of respiratory rate on gapCO2

respiratory rate is 16 breaths/min

GapCO2=Pv-aCO2 = PvCO2 - PaCO2; Effects of venous-to-arterial CO2 tension difference after increased respiratory rate.

Other: Effects of respiratory rate on gapCO2

Interventions

Effects of respiratory rate on gapCO2 OTHER

respiratory rate was started at 10 breaths/min and added by 2 breaths/min every 60 min up to 16 breaths/min

respiratory rate is 10 breaths/min; respiratory rate is 12 breaths/min; respiratory rate is 14 breaths/min; respiratory rate is 16 breaths/min

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The subjects were sequentially admitted to the Department of Critical Care Medicine of 105 Hospital of PLA from March of 2016 till the end of this study.

You may qualify if:

• Patients were included in the study, if the attending physician find the persistence of signs of hypoperfusion (oliguria, mottled skin, central venous oxygen saturation (ScvO2) \<70 % despite a hemoglobin \> 8 g/dl),despite achieving adequate intravascular volume and adequate mean arterial pressure (MAP) \> 65 mmHg as recommended by the Surviving Sepsis Campaign.

Sponsors & Collaborators

• 105 Hospital of Chinese People's Liberation Army: lead

MeSH Terms

Conditions

Shock; Sepsis

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Infections; Systemic Inflammatory Response Syndrome; Inflammation

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 11, 2016
• First Posted: August 16, 2016
• Study Start: October 1, 2015
• Primary Completion: October 1, 2016
• Study Completion: December 1, 2016
• Last Updated: August 18, 2016

Record last verified: 2016-08

Data Sharing

• IPD Sharing: Will share