Central Venous Oxygen Saturation and Carbone Dioxide (CO2)-Derived Indices in the Critically:

NCT05220696 | Completed

• 1 other identifier: RECHMPL22_0003
• Study Type: observational
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

The optimal management of shock states requires a precise evaluation of several parameters, clinical, biological, hemodynamic, and echocardiographic. Among these, parameters that measure O2 and CO2 consumption are of a great interest, especially PCO2 arteriovenous gradient (PCO2 gap) and O2 arteriovenous difference \[D(a-v) O2\]. The PCO2 gap best correlates with cardiac output while the PCO2gap/D(a-v)O2 ratio would be earlier and more specific than blood lactate assay in assessing tissue hypoperfusion secondary to shock. The PCO2 gap and the PCO2gap/D (a-v) O2 ratio have been evaluated from gas measurements of venous blood collected from the pulmonary artery and from the superior vena cava area. However, in some patients the placement of a catheter in the superior vena cava is difficult or even impossible due to thrombosis, vascular occlusions and other reasons… In these cases, the inferior vena cava is used for drugs infusion, nutrition and possibly samples. Gasometric samples in lower cellar territory have not yet been validated and may not be correlated with measurements in upper cellar territory. It is therefore useful for current practice to validate samples in lower cellar territory and demonstrate their correlation with measurements made in upper cellar territory. During an observation period, in patients with catheters in the superior and inferior vena cava for therapeutic indications (renal replacement therapy,...), the investigators systematically took gas measurements at the femoral and jugular sites. the investigators used these data to assess the correlation of PCO2 gap measurements and carbon dioxide-derived indices according to the harvest site : jugular and femoral venous.

Conditions

Shock

Keywords

Adult > 18 YO; Venous catheter in femoral and jugular sites; Arterial catheter; central venous to arterial carbon dioxide difference; central venous to arterial carbon dioxide difference to arterial to venous oxygen difference; central venous oxygen saturation

Outcome Measures

Primary Outcomes (1)

• The correlation of the measurement of indices derived from carbon dioxide (CO2)

  To assess the correlation of the measurement of indices derived from carbon dioxide (CO2) according to the femoral or jugular harvest site in the critically ill patient. Measurements included venous pCO2 and pO2, and central venous saturation ; arterial pO2 and pCO2. From these measurements, carbon dioxides and oxygen variables were calculated as follows : PCO2gap= Pv-aCO2= PvCO2 -PaCO2, where PaCO2 and PvCO2 represent their arterial and venous partial pressures respectively D(a-v)O2= CaO2- CvO2= \[(hg x SaO2 x 1.34) + (Pa02 x O.OO3)\]- \[(hg x SvO2 x 1.34) + (Pv02 x O.OO3)\], where CaO2 and CvO2 are the arterial and venous 02 content, PaO2 and PvO2 represent their arterial and venous partial pressures respectively. Venous measurements are realized in both venous jugular and femoral sites.

  day 1

Secondary Outcomes (1)

• To assess the correlation of the measurement of venous O2 saturation

  day 1

Study Arms (1)

Critically ill patients with shock

Critically ill patients with shock

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Critically ill patients

You may qualify if:

• \- All consecutive critically ill patients who had an arterial catheter and a venous catheter in the superior and inferior vena cava were included.

You may not qualify if:

• An age under 18
• Pregnancy
• Legally protected adults

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

Uhmontpellier

Montpellier, 34295, France

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

NC

MeSH Terms

Conditions

Shock

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Kada KLOUCHE, MD PhD

  UH Montpellier

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 17, 2022
• First Posted: February 2, 2022
• Study Start: July 1, 2020
• Primary Completion: October 1, 2020
• Study Completion: October 20, 2020
• Last Updated: February 2, 2022

Record last verified: 2022-01

Locations

FR (1)