NCT05568290|Unknown
Interleukin-38 Levels in Individuals With Periodontitis
Evaluation of Interleukin-38 Levels in Individuals With Healthy and Periodontal Disease
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Evaluation of Interleukin-38 Levels in Individuals With Healthy and Periodontal Disease
Sponsor study identifier
observational
75
1 country
1
Study Start
September 30, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
November 10, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 10, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to receptors through various pathways and regulate the formation and function of inflammatory cytokines. Periodontitis is a chronic inflammatory disease that can start with localized inflammatory reactions created by the supporting tissues surrounding the teeth against microorganisms and then result in loss of teeth. The aim of this study is to compare the IL-38, IL-1β and IL-10 levels of healthy and periodontitis individuals.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 10, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 10, 2022
Actual (reported)September 30, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
October 5, 2022
Actual (reported)November 10, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 10, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
IL-38 levels
saliva and DOS levels
initial examination, baseline
IL-1β levels
saliva and DOS levels
initial examination, baseline
IL-10 levels
saliva and DOS levels
initial examination, baseline
Plaque Index
initial examination, baseline
Probing Depth
initial examination, baseline
Bleeding on Probe
initial examination, baseline
Individuals with Periodontitis
Individuals with Gingival Inflammation
Individuals with Periodontally Healthy
individuals' saliva samples will be collected and transferred to eppendorf tubes. Until biochemical analysis is carried out will be stored in -80ºC.
Individuals will be divided into three different groups, about 20-25 people in each group.
Saglik Bilimleri Universitesi
Istanbul, Turkey (Türkiye)
Ayşe Toraman, Dr
Saglik Bilimleri Universitesi
First Submitted
September 10, 2022
First Posted
October 5, 2022
Study Start
September 30, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
November 10, 2022
Estimated (date passed)Effect of Non-Surgical Periodontal Treatment on Biomarker Levels
GCF samples of individuals will be collected by paper strips and transferred to eppendorf tubes.Until biochemical analysis is carried out will be stored in -80ºC.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 10, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
October 5, 2022
Record last verified: 2022-09
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Source: ClinicalTrials.gov.
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