Gingival Crevicular IL-34 and CSF-1 Levels in Patients With Periodontitis and Uncontrolled Type 2 Diabetes
Usak University Faculty of Dentistry
1 other identifier
observational
76
1 country
1
Brief Summary
Type 2 diabetes mellitus is a metabolic disorder. There is a bidirectional association between periodontal disease and DM. Currently there is no data relationship between CSF-1 and IL-34, periodontal disease and diabetes.The aim of this study to investigate GCF levels of IL-34 and CSF-1 in periodontitis subjects with diabetes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2021
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 6, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 21, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
May 4, 2021
CompletedFirst Submitted
Initial submission to the registry
May 13, 2021
CompletedFirst Posted
Study publicly available on registry
May 18, 2021
CompletedJanuary 12, 2023
January 1, 2023
4 months
May 13, 2021
January 10, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
It was aimed to compare IL-34 levels by taking gingival crevicular fluid in systemic healthy, periodontitis and diabetic patients with periodontitis groups.
GCF was taken interproximal region.
GCF samples taken within the 1. week after the clinical examination of the patient
Secondary Outcomes (1)
It was aimed to compare CSF-1 levels by taking gingival crevicular fluid in systemic healthy, periodontitis and diabetic patients with periodontitis groups.
GCF samples taken within the 1. week after the clinical examination of the patient
Study Arms (3)
Healthy control groups
individuals with clinically healthy gingiva BOP score less than 10% and PD≤3mm
Periodontitis group
interdental AL ≥5 mm
Periodontitis with diabetes group
HbA1c ≥6.5%
Interventions
GCF samples were collected in the morning hours 24-48 hours after clinical periodontal measurement.
Eligibility Criteria
individuals have diabetes and periodontitis
You may qualify if:
- have 20 teeth
- have diabetes .
You may not qualify if:
- Individuals have systemic disease
- smokers;
- pregnant
- those using drugs;
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Uşak Universitylead
Study Sites (1)
University of Usak
Uşak, 64200, Turkey (Türkiye)
Related Publications (1)
Dikilitas A, Karaaslan F, Evirgen S, Ertugrul AS. Gingival crevicular fluid CSF-1 and IL-34 levels in patients with stage III grade C periodontitis and uncontrolled type 2 diabetes mellitus. J Periodontal Implant Sci. 2022 Dec;52(6):455-465. doi: 10.5051/jpis.2106260313. Epub 2022 Apr 12.
PMID: 36468466DERIVED
Biospecimen
Gingival crevicular fluid
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
ahu dikilitas
University of Usak
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Target Duration
- 3 Weeks
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 13, 2021
First Posted
May 18, 2021
Study Start
January 6, 2021
Primary Completion
April 21, 2021
Study Completion
May 4, 2021
Last Updated
January 12, 2023
Record last verified: 2023-01