NCT04402996|Completed
Meteorin-like Levels in Individuals With Periodontitis
Evaluation of Meteorin-like Levels in Individuals With Healthy and Periodontal Disease
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Evaluation of Meteorin-like Levels in Individuals With Healthy and Periodontal Disease
Sponsor study identifier
observational
60
1 country
1
Study Start
September 23, 2020
Actual (reported)Primary Completion
March 3, 2021
Actual (reported)Study Completion
March 3, 2021
Actual (reported)Metrnl has proven to be an inflammatory-related immunoregulatory cytokine and shown to play a role in the pathogenesis of human inflammatory diseases. Metrnl is highly expressed from the oral mucosa to the esophagus. Periodontitis is a chronic inflammatory disease that can start with localized inflammatory reactions created by the supporting tissues surrounding the teeth against microorganisms and then result in loss of teeth. The authors think that Metrnl may play a role in the periodontitis. The aim of this study is to compare the Metrnl, IL-1β, and IL-10 levels of healthy and periodontitis individuals.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 3, 2021
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 19, 2020
Actual (reported)May 27, 2020
Actual (reported)September 23, 2020
Actual (reported)March 3, 2021
Actual (reported)March 3, 2021
Actual (reported)IL-1β
saliva and serum levels
through study completion, an average of 6 months
Metrnl
saliva and serum levels
through study completion, an average of 6 months
IL-10 levels
saliva and serum levels
through study completion, an average of 6 months
Plaque Index
up to 20 weeks
Probing Depth
up to 20 weeks
Bleeding on Probe
up to 20 weeks
Individuals with Periodontally Healthy
Individuals with Gingival Inflammation
Individuals with Periodontitis
individuals' saliva samples will be collected and transferred to eppendorf tubes. Until biochemical analysis is carried out will be stored in -80ºC.
Individuals will be divided into three different groups, about 20-25 people in each group.
Ebru Sağlam
Istanbul, Eyalet/Yerleşke, 34668, Turkey (Türkiye)
Gingival Crevicular Fluid and Saliva
Ayşe Toraman, Dr.
Saglik Bilimleri Universitesi
Serhat Köseoğlu, assoc prof
Saglik Bilimleri Universitesi
Mehmet Sağlam, assoc prof
Izmir Katip Celebi University
Levent Savran, PhD
Izmir Katip Celebi University
60 participants (actual enrollment reported by the registry).
First Submitted
May 19, 2020
First Posted
May 27, 2020
Study Start
September 23, 2020
Actual (reported)Gingival Crevicular IL-34 and CSF-1 Levels in Patients With Periodontitis and Uncontrolled Type 2 Diabetes
GCF samples of individuals will be collected by paper strips and transferred to eppendorf tubes. Until biochemical analysis is carried out will be stored in -80ºC.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Ebru Sağlam, Dr
Saglik Bilimleri Universitesi
Primary Completion
March 3, 2021
Actual (reported)Study Completion
March 3, 2021
Actual (reported)Last Updated
April 29, 2024
Record last verified: 2024-04
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Source: ClinicalTrials.gov.
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