Evaluation of Mandibular Bone Microstructure Changes After Periodontal Treatment (M-BONE Study)

NCT07488403 | Completed

• 1 other identifier: TBAEK-283
• Study Type: observational
• Target: 69
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective study evaluates how non-surgical treatment for gum disease affects the bone of the mandible. Gum disease (periodontitis) can lead to changes in the bone supporting the teeth, but these changes are not always easy to detect with routine clinical examination. Previously collected clinical and radiographic data from patients with moderate and severe gum disease (Stage II and Stage III periodontitis), as well as individuals with gingivitis, were analyzed. All participants had received standard periodontal treatment as part of routine care. Radiographic images taken before treatment and 6 months after treatment were examined using fractal analysis, a method used to assess bone structure. The results of this study may help improve understanding of how periodontal treatment influences bone structure and may support the use of radiographic analysis as a tool for monitoring treatment outcomes.

Conditions

Gingivitis; Periodontitis

Keywords

periodontitis; Fractal analysis; Fractal dimension; Panoramic radiography; Periapical radiography; Gingivitis; Non-surgical periodontal therapy

Outcome Measures

Primary Outcomes (1)

• Change in Mandibular Bone Microstructure Assessed by Fractal Dimension

  Fractal dimension values obtained from predefined regions of interest on periapical and panoramic radiographs to evaluate changes in mandibular trabecular bone microstructure before treatment and 6 months after non-surgical periodontal therapy.

  Baseline and 6 months after treatment

Study Arms (3)

Stage II Periodontitis

Patients diagnosed with Stage II periodontitis who received non-surgical periodontal therapy.

Stage III Periodontitis

Patients diagnosed with Stage III periodontitis who received non-surgical periodontal therapy.

Gingivitis

Individuals with gingivitis who received routine periodontal care

Eligibility Criteria

• Age: 18 Months - 70 Months
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Patients treated at the Department of Periodontology, Akdeniz University Faculty of Dentistry, with available clinical and radiographic records suitable for retrospective evaluation. The study population includes individuals diagnosed with Stage II and Stage III periodontitis, as well as individuals with gingivitis.

You may qualify if:

• Individuals aged 18 years and older
• Patients diagnosed with Stage II or Stage III periodontitis, or gingivitis
• Patients who received non-surgical periodontal therapy
• Availability of complete clinical periodontal records
• Availability of periapical and panoramic radiographs at baseline and 6 m

You may not qualify if:

• Patients with systemic diseases affecting bone metabolism
• History of periodontal treatment within the last 6 months
• Use of medications affecting bone metabolism
• Pregnant or lactating individuals
• Poor quality or missing radiographic records

Sponsors & Collaborators

• Akdeniz University: lead

Study Sites (1)

Akdeniz University Faculty of Dentistry

Antalya, KONYAALTI, 07700, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Periodontitis; Gingivitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Infections; Gingival Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: association professor

Study Record Dates

• First Submitted: March 18, 2026
• First Posted: March 23, 2026
• Study Start: January 1, 2023
• Primary Completion: January 1, 2024
• Study Completion: January 1, 2024
• Last Updated: March 27, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)