NCT04850768|Unknown
(NOD)-Like Receptors CARD Domain-Containing 4 Levels in Individuals With Periodontitis
Evaluation of (NOD)-Like Receptors CARD Domain-containing 4 Levels in Individuals With Healthy and Periodontal Disease
Loading search results
Evaluation of (NOD)-Like Receptors CARD Domain-containing 4 Levels in Individuals With Healthy and Periodontal Disease
Sponsor study identifier
observational
75
1 country
1
Study Start
April 16, 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
July 20, 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
September 20, 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
NLRC4, an inflammasome , is a cytosolic multiprotein complex involved in the initiation and modulation of the immune response. Periodontitis is a chronic inflammatory disease that can start with localized inflammatory reactions created by the supporting tissues surrounding the teeth against microorganisms and then result in loss of teeth. It has been said that proinflammatory cytokines released in the microenvironment of periodontitis can increase the expression of NLRC4 inflammasome genes. The authors think that NLRC4 may play a role in the periodontitis. The aim of this study is to compare the NLRC4, IL-1β and IL-10 levels of healthy and periodontitis individuals.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 20, 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 14, 2021
Actual (reported)April 16, 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
April 20, 2021
Actual (reported)July 20, 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
September 20, 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
IL-1β levels
saliva and DOS levels
through study completion, an average of 6 months
IL-10 levels
saliva and DOS levels
through study completion, an average of 6 months
NLRC4
saliva and DOS levels
through study completion, an average of 6 months
Plaque Index
up to 20 weeks
Probing Depth
up to 20 weeks
Bleeding on Probe
up to 20 weeks
Individuals with Periodontitis
Individuals with Gingival Inflammation
Individuals with Periodontally Healthy
individuals' saliva samples will be collected and transferred to eppendorf tubes. Until biochemical analysis is carried out will be stored in -80ºC.
Individuals will be divided into three different groups, about 20-25 people in each group.
Saglik Bilimleri Universitesi
Istanbul, Turkey (Türkiye)
Saliva and gingival crevicular fluid
Ayşe Toraman, Dr
Saglik Bilimleri Universitesi
Ebru Sağlam, Dr
Saglik Bilimleri Universitesi
Serhat Köseoğlu, assoc prof
Saglik Bilimleri Universitesi
Mehmet Sağlam, assoc prof
Izmir Katip Celebi University
First Submitted
April 14, 2021
First Posted
April 20, 2021
Study Start
April 16, 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
July 20, 2021
Gingival Crevicular IL-34 and CSF-1 Levels in Patients With Periodontitis and Uncontrolled Type 2 Diabetes
GCF samples of individuals will be collected by paper strips and transferred to eppendorf tubes.Until biochemical analysis is carried out will be stored in -80ºC.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Levent Savran, PhD
Izmir Katip Celebi University
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
September 20, 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
April 20, 2021
Record last verified: 2021-04
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: