Impact of Hand Grip Strength on Length of Hospital Stay After Cardiac Surgery Among Elderly Patients

NCT05546671 | Recruiting

• 1 other identifier: 2022/13/621
• Study Type: observational
• Target: 240
• Locations: 1 country
• Sites: 1

Brief Summary

Hand grip strength has been shown to be a predictor of adverse cardiovascular outcomes in the elderly population. This study aims to investigate whether measurement of hand grip strength could be used as a predictor of prolonged hospital stay after cardiac surgery in elderly patients.

Conditions

Sarcopenia; Frailty

Outcome Measures

Primary Outcomes (1)

• Prolonged hospital stay

  Prolonged hospital stay is defined as postoperative hospital stay for ≥14 days.

  14 days

Secondary Outcomes (2)

• Prolonged intensive care unit stay

  48 hours

• Prolonged mechanical ventilation

  12 hours

Study Arms (2)

Strong grippers

Diagnostic Test: Hand grip strength measurement

Weak grippers

Diagnostic Test: Hand grip strength measurement

Interventions

Hand grip strength measurement DIAGNOSTIC_TEST

Preoperative hand grip strength will be measured in kilograms using a digital hand dynamometer (Baseline Smedley Digital Hand Dynamometer, Model 12-0286, Baseline Evaluation Instruments, China). Participants will be instructed to grip the hand dynamometer for 5 seconds with their dominant hand 3 times. They will be allowed to rest for 20 second between each grip. The highest measurement of 3 attempts will be recorded. Participants will be categorized as "strong grippers" or "weak grippers" according to Fried criteria as previously defined by Linda P. Fried and colleagues. A weak grip will be defined as follows: For men: BMI ≤24: hand grip strength ≤29 kg; BMI =24.1 to 28: hand grip strength ≤30 kg; BMI \>28: hand grip strength ≤32 kg For women: BMI ≤23: hand grip strength ≤17 kg; BMI =23.1 to 26: hand grip strength ≤17.3 kg; BMI =26.1 to 29: hand grip strength ≤18 kg; BMI \>29: hand grip strength ≤21 kg

Strong grippers; Weak grippers

Eligibility Criteria

• Age: 70 Years+
• Sex: all
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Study population will be comprised of all consecutive patients ≥70 years of age undergoing elective coronary artery bypass and/or valve surgery at the Department of Cardiovascular Surgery at Kosuyolu Training and Research Hospital.

You may qualify if:

• Age ≥70 years
• Undergoing isolated coronary artery bypass grafting or isolated valve surgery or combined coronary and valve procedures
• Being oriented and cooperative enough to understand and comply with the instruction of gripping the hand dynamometer

You may not qualify if:

• Age \<70 years
• Emergent status
• Hemodynamic instability
• Inability to cooperate due to neurocognitive disorder
• Loss of upper extremity motor function of any degree (such as due to previous stroke)
• History of upper extremity amputation of any level

Sponsors & Collaborators

• Kartal Kosuyolu High Speciality Training and Research Hospital: lead

Study Sites (1)

Kosuyolu High Specialization Education and Research Hospital

Istanbul, 34865, Turkey (Türkiye)

RECRUITING

Related Publications (3)

• Perry IS, Pinto LC, da Silva TK, Vieira SRR, Souza GC. Handgrip Strength in Preoperative Elective Cardiac Surgery Patients and Association With Body Composition and Surgical Risk. Nutr Clin Pract. 2019 Oct;34(5):760-766. doi: 10.1002/ncp.10267. Epub 2019 Mar 13.

  PMID: 30864228 BACKGROUND

• Fu L, Zhang Y, Shao B, Liu X, Yuan B, Wang Z, Chen T, Liu Z, Liu X, Guo Q. Perioperative poor grip strength recovery is associated with 30-day complication rate after cardiac surgery discharge in middle-aged and older adults - a prospective observational study. BMC Cardiovasc Disord. 2019 Nov 27;19(1):266. doi: 10.1186/s12872-019-1241-x.

  PMID: 31775633 BACKGROUND

• Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56. doi: 10.1093/gerona/56.3.m146.

  PMID: 11253156 BACKGROUND

MeSH Terms

Conditions

Sarcopenia; Frailty

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Pathologic Processes

Central Study Contacts

Ahmet Can Topcu, MD

CONTACT

902165001500; ahmet.topcu@icloud.com

Murat Bulent Rabus, Prof

CONTACT

902165001500; muratbulent.rabus@sbu.edu.tr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Cardiovascular Surgery Specialist

Study Record Dates

• First Submitted: September 15, 2022
• First Posted: September 21, 2022
• Study Start: November 1, 2022
• Primary Completion: October 31, 2024
• Study Completion: November 30, 2024
• Last Updated: March 15, 2024

Record last verified: 2024-03

Locations

TU (1)