Investigation of the Effects of Frailty and Sarcopenia on Postoperative Recovery and Complications in Geriatric Patients

NCT06889714 | Completed

• 1 other identifier: Eskisehir
• Study Type: observational
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

After obtaining ethical approval, 42 patients with American Society of Anesthesiologists (ASA) scores I-III who were scheduled for surgery under general anesthesia were included in our prospective study. Patients were monitored in the preoperative preparation room in the operating room and frailty was assessed using the FRAIL scale and sarcopenia was assessed using the STAR ratio. The thickness of the rectus femoris and vastus intermedius muscles of the patients was measured and recorded by ultrasonography. Thigh lengths were measured and recorded. Rectus Femoris/Thigh Length (RF/B), Vastus Intermedius/Thigh Length (VI/B), and Total Muscle Thickness/Thigh Length (T/B) were calculated and recorded. Patients were followed up according to the Modified Aldrete Score after surgery in the anesthesia recovery unit, and the time to reach 9-10 points was recorded, and the time to leave the recovery unit was recorded. Postoperatively, complications were followed up according to the Clavien-Dindo Classification, and discharge times from the hospital were recorded.

Conditions

Frailty; Sarcopenia

Keywords

geriatric anesthesia; sarcopenia; ultrasonography; postoperative complications; quadriceps femoris

Outcome Measures

Primary Outcomes (16)

• age

  years old

  1 year

• sex

  female, male

  1 year

• height

  meter

  1 year

• body weight

  kg

  1. year

• educational status

  primary school graduate, middle school graduate, high school graduate, university graduate

  1 year

• marital status

  married, single, widowed

  1 year

• ASA score

  American Society of Anesthesiologists' Classification (ASA 1,2,3,4,5)

  1 year

• rectus femoris muscle thickness

  cm

  1 year

• vastus intermedius(VI) thickness

  cm

  1 year

• rectus femoris-to-thigh length ratio

  ratio

  1 year

• vastus intermedius-thigh length ratio

  ratio

  1 year

• total muscle thickness to thigh length ratio

  ratio

  1 year

• frailty score

  0-NORMAL, 1-2 PRE-FRAİL, 3-5 FRAİL

  1 year

• recovery time from anesthesia

  minutes

  1 year

• hospital discharge time

  days

  1 year

• Modified Clavien-Dindo Classification

  1, 2, 3A, 3B, 4A, 4B, 5

  1 year

Interventions

ultrasonography DEVICE

Right thigh length (between the right femur greater trochanter and patella) was measured and recorded while the patients were lying supine. A linear transducer (Philips Affiniti 50, Philips Medical Systems, Seattle, WA, United States) was used for ultrasonographic measurements. The rectus femoris (RF) and vastus intermedius (VI) were visualized with the feather-touch technique after a generous amount of ultrasound gel was sprayed in the center of the right thigh, and the thickness of the muscles was determined and recorded using ultrasonography software. After these measurements, the rectus femoris-to-thigh length ratio (RF/B), vastus intermedius-to-thigh length ratio (VI/B), and total muscle thickness-to-thigh length ratio (T/B) were calculated and recorded.

Eligibility Criteria

• Age: 60 Years+
• Gender Eligibility Details: all genders were accepted to the study without gender discrimination
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

42 patients over 60 years of age with ASA score I-III who were to undergo colorectal malignancy surgery under general anesthesia

You may qualify if:

• patients over 60 years of age who are undergoing colorectal malignancy surgery under general anesthesia
• patients willing to participate in the study
• Patients with ASA score I-III

You may not qualify if:

• Patients with Parkinson's disease,
• Alzheimer's disease,
• history of cerebrovascular events,
• neuromuscular disease,
• cognitive dysfunction,
• severe liver disease,
• severe heart disease,
• impaired cooperation due to kidney disease,
• emergency and trauma patients,
• patients with bilateral lower extremity amputations

Sponsors & Collaborators

• Eskisehir Osmangazi University: lead

Study Sites (1)

University of Eskisehir Osmangazi

Eskişehir, Odunpazarı, 26040, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Frailty; Sarcopenia; Postoperative Complications

Interventions

Ultrasonography

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• ferda yaman, Assoc prof

  University of Eskişehir Osmangazi

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 17, 2025
• First Posted: March 21, 2025
• Study Start: July 20, 2023
• Primary Completion: July 20, 2024
• Study Completion: July 20, 2024
• Last Updated: March 27, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)