Hand Grip Strength and Prognosis in Hospitalized Cancer Patients

NCT07167082 | Completed

• 1 other identifier: AEŞH-BADEK-2024-1105
• Study Type: observational
• Target: 130
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective cohort study aims to investigate the relationship between hand grip strength and prognosis in hospitalized cancer patients. Hand grip strength, a simple, rapid, and non-invasive measure of overall muscle function, is increasingly recognized as an indicator of frailty, nutritional status, and physical health. The study will evaluate whether lower hand grip strength is associated with higher short-term mortality (30-day all-cause mortality) and adverse clinical outcomes, including ICU admission, hospital readmission, and functional decline.

Conditions

Cancer; Hospitalizations; Sarcopenia; Cachexia; Cancer; Sarcopenia

Keywords

Hand Grip Strength; Prognosis; Hospitalized Cancer Patients; Cachexia; Malnutrition; Functional Decline; Mortality

Outcome Measures

Primary Outcomes (1)

• 30-day All-Cause Mortality

  All-cause mortality within 30 days of hospital admission among cancer patients (Yes/No). Mortality status will be assessed through hospital records and follow-up. Hand grip strength values will be analyzed in relation to mortality risk.

  30 days after hospital admission

Secondary Outcomes (6)

• Intensive Care Unit Admission

  30 days after hospital admission

• Hospital Readmission

  30 days after discharge

• Functional Decline - ECOG Performance Status

  Baseline and 30 days after hospital admission

• Length of Hospital Stay

  Through initial hospitalization, up to 30 days

• Major Complications

  30 days after hospital admission

Study Arms (1)

Hospitalized Cancer Patients

This cohort consists of adult patients (aged 18-80 years) with pathologically confirmed cancer who are admitted to the hospital for at least 48 hours. Hand grip strength is measured within the first 24 hours of admission using a standardized dynamometer protocol. Patients are followed prospectively for 30 days to evaluate primary and secondary outcomes including all-cause mortality, functional decline, hospital stay duration, readmission, and major complications.

Other: Hand Grip Strength Measurement

Interventions

Hand Grip Strength Measurement OTHER

Hand grip strength will be measured within the first 24 hours of hospitalization using a calibrated hand dynamometer. Measurements will be performed on the dominant hand, with patients seated, following standardized international procedures. Three consecutive measurements will be obtained, and the average value will be recorded. The test is non-invasive, quick, and performed by oncology clinicians trained in the protocol.

Hospitalized Cancer Patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients aged 18 years and older with pathologically confirmed cancer who are admitted to the Ankara Etlik City Hospital, Department of Medical Oncology. Eligible participants are hospitalized for more than 48 hours and undergo hand grip strength measurement within 24 hours of admission. Patients represent a heterogeneous group of solid tumor cases across different cancer types and stages, reflecting a real-world hospitalized oncology population.

You may qualify if:

• Adults aged 18 years and older
• Pathologically confirmed diagnosis of cancer
• Hospitalized with an expected hospital stay of more than 48 hours
• Ability to provide written informed consent

You may not qualify if:

• Diagnosis of anorexia nervosa
• Acute pancreatitis or acute liver failure at admission
• History of gastric bypass surgery
• Presence of chronic active infections
• History of solid organ transplantation
• Pregnant or breastfeeding women

Sponsors & Collaborators

• Ankara Etlik City Hospital: lead

Study Sites (1)

Etlik City Hospital, Medical Oncology Department

Ankara, Yenimahalle, 06210, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Neoplasms; Sarcopenia; Cachexia; Malnutrition

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Weight Loss; Body Weight Changes; Body Weight; Thinness; Nutrition Disorders; Nutritional and Metabolic Diseases

Study Officials

• Galip Can Uyar, MD

  Ankara Etlik City Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Oncologist, Department of Medical Oncology

Study Record Dates

• First Submitted: August 23, 2025
• First Posted: September 11, 2025
• Study Start: September 1, 2024
• Primary Completion: October 20, 2024
• Study Completion: March 25, 2025
• Last Updated: September 11, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)