Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty

NCT04717869 | Recruiting

• 1 other identifier: 20-002271
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern. Although multiple measures exist that can identify frail patients, very little is known about how or when to intervene. Sarcopenia, or the degree of muscle wasting, is closely correlated to frailty and patient outcomes. This is a prospective cohort study of critically ill patients to identify modifiable risk factors of sarcopenia, as potential targets to reduce frailty.

Conditions

Frailty; Sarcopenia

Keywords

Frailty; Sarcopenia; Ultrasound

Outcome Measures

Primary Outcomes (3)

• Discharge Disposition

  Disposition of patient at time of hospital discharge, home, rehabilitation or skilled nursing facility, in hospital death

  Patients will be followed from enrollment to hospital discharge. Approximately 2 weeks to 2 months

• Length of ICU stay

  Length of time patient is admitted to ICU until transfer out of the ICU

  Patients will be followed from enrollment to ICU transfer. Approximately 2 weeks to 2 months

• Length of Hospital stay

  Length of time patient is admitted to the hospital including length of time patient spends in the ICU until discharge or death

  Patients will be followed from enrollment until discharge from the hospital. Approximately 2 weeks to 2 months

Secondary Outcomes (1)

• Adverse Events

  Patients will be followed from enrollment to 1 year.

Study Arms (1)

ICU Patients

Adult Surgical, Cardiothoracic, and Neuro- ICU patients will be enrolled within 48 hrs of admission

Diagnostic Test: Ultrasound; Diagnostic Test: Biomarker Analysis; Other: Frailty Index

Interventions

Ultrasound DIAGNOSTIC_TEST

2D ultrasound image collection

ICU Patients

Biomarker Analysis DIAGNOSTIC_TEST

Inflammatory and nutritional biomarker analysis

ICU Patients

Frailty Index OTHER

A Frailty Index Questionnaire be completed by patients or their surrogates to determine the presence of frailty at ICU admission

Also known as: Questionnaire

ICU Patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients admitted to the the Surgical, Cardiothoracic, or Neuro ICU.

You may qualify if:

• Adult patients admitted to the Surgical, Cardiothoracic or Neuro ICU
• ICU stay longer than 24 hours

You may not qualify if:

• Patients with muscular or mitochondrial diseases affecting muscle quality or mass
• Preexisting paralysis
• Absence of lower limbs
• Ongoing discussions about goals of care
• Transfers from a skilled nursing facility
• Children under the age of 18

Sponsors & Collaborators

• University of California, Los Angeles: lead

Study Sites (1)

Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine

Los Angeles, California, 90095, United States

RECRUITING

Related Publications (29)

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  BACKGROUND

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MeSH Terms

Conditions

Frailty; Sarcopenia

Interventions

Ultrasonography; Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Cecilia Canales, MD, MPH

  UCLA Department of Anesthesiology and Perioperative Medicine

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jennifer Scovotti, MA

CONTACT

3102064484; jscovotti@mednet.ucla.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 12, 2021
• First Posted: January 22, 2021
• Study Start: September 22, 2023
• Primary Completion: May 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: January 30, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)