Efficacy of Different Doses of Tai Chi Chuan on Cognitive Function in Persons With Mild Cognitive Impairment

NCT06375720 | Not Yet Recruiting DMC

• 1 other identifier: FujianUTCM-2
• Study Type: interventional
• Target: 350
• Locations: 0 countries
• Sites: N/A

Brief Summary

To determine the relationship between the effects of different frequencies and duration of Tai Chi Chuan in dose parameters to improve cognitive function in elderly persons with mild cognitive impairment.

Conditions

Mild Cognitive Impairment

Keywords

Tai Chi Chuan; Cognitive Function

Outcome Measures

Primary Outcomes (1)

• Montreal Cognitive Assessment

  Global cognition

  12 weeks, 24 weeks

Secondary Outcomes (8)

• Montreal Cognitive Assessment

  52 weeks

• Wechsler Memory Scale

  12 weeks, 24 weeks and 52 weeks

• Digit Symbol Substitution Test

  12 weeks, 24 weeks and 52 weeks

• Trial Making Test part B

  12 weeks, 24 weeks and 52 weeks

• Stroop Color Word Test

  12 weeks, 24 weeks and 52 weeks

Other Outcomes (8)

• The Pittsburgh Sleep Quality Index (PSQI)

  12 weeks, 24 weeks and 52 weeks

• 12-Item Short Form Health Survey

  12 weeks, 24 weeks and 52 weeks

• Blood glucose metabolism index

  12 weeks, 24 weeks and 52 weeks

Study Arms (5)

Tai Chi Chuan Group1

EXPERIMENTAL

12 weeks of Tai Chi Chuan, 3x/week

Behavioral: Lower frequency, shorter period of Tai Chi Chuan

Tai Chi Chuan Group2

EXPERIMENTAL

12 weeks of Tai Chi Chuan, 5x/week

Behavioral: Higher frequency, shorter period of Tai Chi Chuan

Tai Chi Chuan Group3

EXPERIMENTAL

24 weeks of Tai Chi Chuan, 3x/week

Behavioral: Lower frequency, longer period of Tai Chi Chuan

Tai Chi Chuan Group4

EXPERIMENTAL

24 weeks of Tai Chi Chuan, 5x/week

Behavioral: Higher frequency, longer period of Tai Chi Chuan

Control

SHAM COMPARATOR

Participants would take standard health education 0.5hour/ session, 2 sessions/month for 6 months.

Behavioral: Standard Health Education

Interventions

Lower frequency, shorter period of Tai Chi Chuan BEHAVIORAL

Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 3 sessions/week for 12 weeks. There were 10 minutes warm-up, 40 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. Besides, they would also take standard health education 0.5 hour/session, 2 sessions/month for 6 months.

Tai Chi Chuan Group1

Higher frequency, shorter period of Tai Chi Chuan BEHAVIORAL

Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 5 sessions/week for 12 weeks. There were 10 minutes warm-up, 40 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. Besides, they would also take standard health education 0.5 hour/session, 2 sessions/month for 6 months.

Tai Chi Chuan Group2

Lower frequency, longer period of Tai Chi Chuan BEHAVIORAL

Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 3 sessions/week for 24 weeks. There were 10 minutes warm-up, 40 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. Besides, they would also take standard health education 0.5 hour/session, 2 sessions/month for 6 months.

Tai Chi Chuan Group3

Higher frequency, longer period of Tai Chi Chuan BEHAVIORAL

Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 5 sessions/week for 24 weeks. There were 10 minutes warm-up, 40 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. Besides, they would also take standard health education 0.5 hour/session, 2 sessions/month for 6 months.

Tai Chi Chuan Group4

Standard Health Education BEHAVIORAL

Participants would take standard health education 0.5 hour/ session, 2 sessions/month for 6 months.

Control

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Presence of mild cognitive impairment, not demented;
• Age ≥ 60 years old;
• Informed consent and voluntary participation.

You may not qualify if:

• Geriatric Depression Scale score ≥ 9 points;
• Cognitive impairment caused by other reasons, taking drugs, poisoning, etc;
• Suffer from severe musculoskeletal system diseases and other contraindications to exercise and are not suitable for Tai Chi Chuan training, such as those who suffer from stroke, Parkinson's disease, and have a history of lower limb arthritis, hip and knee joint replacement, etc;
• Patients with severe heart, liver, kidney failure, malignant tumors, and other major diseases;
• Individuals with visual/auditory impairments, writing/reading impairments, illiteracy, etc. that affect training and evaluation;
• Individuals with uncontrolled hypertension (systolic blood pressure greater than 160mmHg or diastolic blood pressure greater than 100mmHg after medication);
• Participating in other experiments that influence this study;
• Engaged in regular exercise in the last three months (at least 3 times a week, at least 20 minutes of regular exercise each time).

Sponsors & Collaborators

• Lidian Chen: lead
• Peking University Third Hospital: collaborator

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Fujian University of Traditional Chinese Medicine

Study Record Dates

• First Submitted: March 21, 2024
• First Posted: April 19, 2024
• Study Start: May 5, 2024
• Primary Completion: June 15, 2025
• Study Completion: December 15, 2025
• Last Updated: April 19, 2024

Record last verified: 2024-04